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C7 native protein :: Complement C7 Native Protein

Scan QR to view Datasheet Catalog #    MBS537072 C7 native protein
Unit / Price
0.25 mg  /  $485 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement C7, Native Protein

★Popular Item★
 Also Known As   

Complement C7 protein

 Product Synonym Names    C& protein
 Product Gene Name   

C7 native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    217070
 3D Structure    ModBase 3D Structure for P10643
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 Host    Human
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 Purity/Purification    > 98% pure
 Form/Format    Supplied as a liquid in PBS, pH 7.2, no preservatives added.
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 Source Note    Human serum/plasma
 Protein Type    Native
 Biological Significance    Native human C7 is a naturally glycosylated protein composed of a single polypeptide chain of 92,400 Da. C7 is essential for formation of the membrane attack complex (MAC) and is activated non-proteolytically by binding to recently-formed C5b,C6 complexes at the cell membrane. Each pathway of complement activation generates proteolytic enzyme complexes (C3/C5 convertases) which are bound to the target surface.
 Biohazard Information    Donor samples were tested and found to be negative for HBsAg, HTLV-I/II, STS, and for antibodies to HCV, HIV-1 and HIV-II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
 Dry Ice Shipment    Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
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 Preparation and Storage    Aliquot and store at -70 degree C or lower. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of C7 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for C7 native protein

   Purified Complement C7 protein isolated from human plasma
 Product Categories/Family for C7 native protein    Immunology; Native Protein; Complements
NCBI/Uniprot data below describe general gene information for C7. It may not necessarily be applicable to this product.
 NCBI GI #    45580688
 NCBI GeneID    730
 NCBI Accession #    NP_000578.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000587.2 [Other Products]
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 UniProt Primary Accession #    P10643 [Other Products]
 UniProt Secondary Accession #    Q6P3T5; Q92489 [Other Products]
 UniProt Related Accession #    P10643 [Other Products]
 Molecular Weight    92.4 kDa [Similar Products]
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 NCBI Official Full Name    complement component C7
 NCBI Official Synonym Full Names    complement component 7
 NCBI Official Symbol    C7 [Similar Products]
 NCBI Protein Information    complement component C7
 UniProt Protein Name    Complement component C7
 Protein Family    Complement component
 UniProt Gene Name    C7 [Similar Products]
 UniProt Entry Name    CO7_HUMAN
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 NCBI Summary for C7    C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008]
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 UniProt Comments for C7    C7: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5p13

Cellular Component: membrane attack complex; extracellular region

Biological Process: cellular sodium ion homeostasis; cytolysis; complement activation, alternative pathway; regulation of complement activation; innate immune response; complement activation, classical pathway; complement activation

Disease: Complement Component 7 Deficiency
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 Research Articles on C7    1. Borrelial CspA binds the human terminal complement components C7 and C9 and blocks assembly and membrane insertion of the terminal complement complex (TCC).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with C7 native proteinPathways associated with C7 native protein
 Reference Product  PubMed Publications
 CD59 native protein  >24 publications with C7 and CD59
 C8G native protein  >8 publications with C7 and C8G
 C8A native protein  >6 publications with C7 and C8A
 C8B native protein  >5 publications with C7 and C8B
 Products by Pathway  Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Regulation Of Complement Cascade Pathway antibodies  Regulation Of Complement Cascade Pathway Diagram
Diseases associated with C7 native proteinOrgans/Tissues associated with C7 native protein
 Disease Name  Pubmed Publications
 Neuromuscular Diseases Antibodies  >491 publications with C7 and Neuromuscular Diseases
 Brain Diseases Antibodies  >213 publications with C7 and Brain Diseases
 Hemolysis Antibodies  >152 publications with C7 and Hemolysis
 Inflammation Antibodies  >130 publications with C7 and Inflammation
 Hemorrhage Antibodies  >109 publications with C7 and Hemorrhage
 Male Urogenital Diseases Antibodies  >103 publications with C7 and Male Urogenital Diseases
 Necrosis Antibodies  >79 publications with C7 and Necrosis
 Kidney Diseases Antibodies  >67 publications with C7 and Kidney Diseases
 Lung Diseases Antibodies  >62 publications with C7 and Lung Diseases
 Nerve Degeneration Antibodies  >52 publications with C7 and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2227 publications with C7 and Bone
 Nerve Antibodies  >1039 publications with C7 and Nerve
 Muscle Antibodies  >851 publications with C7 and Muscle
 Brain Antibodies  >486 publications with C7 and Brain
 Vascular Antibodies  >321 publications with C7 and Vascular
 Liver Antibodies  >201 publications with C7 and Liver
 Heart Antibodies  >197 publications with C7 and Heart
 Kidney Antibodies  >165 publications with C7 and Kidney
 Ganglia Antibodies  >133 publications with C7 and Ganglia
 Lung Antibodies  >128 publications with C7 and Lung
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