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EPX native protein :: Eosinophil peroxidase Native Protein

Scan QR to view Datasheet Catalog #    MBS318345 EPX native protein
Unit / Price
0.2 mg  /  $1,030 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Eosinophil peroxidase (EPX), Native Protein

★Popular Item★
 Also Known As   

Human Eosinophil peroxidase

 Product Gene Name   

EPX native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (56270089..56282535). Location: 17q23.1
 OMIM    131399
 3D Structure    ModBase 3D Structure for P11678
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 Host    Human eosinophil
 Species Reactivity    Human
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 Specificity    Eosinophil peroxidase
 Purity/Purification    >90% pure (SDS-PAGE)
 Form/Format    Purified, Liquid
 Concentration    0.526mg/ml (lot specific)
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 Inactivation    Not applicable
 Buffer    20mM HEPES-NaOH, pH 8.0 containing 0.4M Sodium chloride, 0.1mM PMSF, 0.02% Lubrol
 Preservative    Proprietary formula containing 0.1% preservative, bromo-nitro-dioxane/methylisothiazolone
 Dry Ice Shipment    Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
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 Preparation and Storage    Store at -20 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of EPX native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for EPX native protein    Purified Autoimmune Reagents
NCBI/Uniprot data below describe general gene information for EPX. It may not necessarily be applicable to this product.
 NCBI GI #    4503595
 NCBI GeneID    8288
 NCBI Accession #    NP_000493.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000502.4 [Other Products]
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 UniProt Primary Accession #    P11678 [Other Products]
 UniProt Secondary Accession #    Q4TVP3 [Other Products]
 UniProt Related Accession #    P11678 [Other Products]
 Molecular Weight    81,040 Da [Similar Products]
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 NCBI Official Full Name    eosinophil peroxidase preproprotein
 NCBI Official Synonym Full Names    eosinophil peroxidase
 NCBI Official Symbol    EPX [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    eosinophil peroxidase
 UniProt Protein Name    Eosinophil peroxidase
 Protein Family    Eosinophil peroxidase
 UniProt Gene Name    EPX [Similar Products]
 UniProt Synonym Gene Names    EPER; EPO; EPP [Similar Products]
 UniProt Entry Name    PERE_HUMAN
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 NCBI Summary for EPX    This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq]
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 UniProt Comments for EPX    Function: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. Ref.5 Ref.6

Catalytic activity: 2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactor: Binds 1 calcium ion per heterodimer

By similarity.Binds 1 heme B (iron-protoporphyrin IX) covalently through ester linkages to hydroxylated methyl groups formed auto-catalytically with hydrogen peroxide at the heme C-1 and C-5 positions. The ester linkage to Asp-232 was observed in 30% of the chains.

Subunit structure: Tetramer of two light chains and two heavy chains.

Subcellular location: Cytoplasmic granule. Note: Cytoplasmic granules of eosinophils.

Polymorphism: Allelic variant in EPX is associated with Japanese cedar pollinosis which is a type I allergic disease with ocular and nasal symptoms that develop paroxysmally on contact with Japanese cedar pollen. These symptoms, which occur seasonally each year, are typical features of allergic rhinitis, such as sneezing, excessive nasal secretion, nasal congestion, and conjunctival itching.

Involvement in disease: Defects in EPX are the cause of eosinophil peroxidase deficiency (EPD) [

MIM:261500]. EPD is an autosomal recessive defect where anomalous eosinophils are characterized by nuclear hypersegmentation, hypogranulation, and negative peroxidase and phospholipid staining. Ref.7

Sequence similarities: Belongs to the peroxidase family. XPO subfamily.
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 Research Articles on EPX    1. EPO-dependent oxidative damage may play a role in tissue injury in bisulfite-exacerbated eosinophilic inflammatory disorders
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with EPX native proteinDiseases associated with EPX native protein
 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Disease Name  Pubmed Publications
 Asthma Antibodies  >82 publications with EPX and Asthma
 Inflammation Antibodies  >81 publications with EPX and Inflammation
 Eosinophilia Antibodies  >18 publications with EPX and Eosinophilia
 Rhinitis Antibodies  >12 publications with EPX and Rhinitis
 Colitis Antibodies  >10 publications with EPX and Colitis
 Inflammatory Bowel Diseases Antibodies  >8 publications with EPX and Inflammatory Bowel Diseases
 Bronchial Hyperreactivity Antibodies  >8 publications with EPX and Bronchial Hyperreactivity
 Recurrence Antibodies  >4 publications with EPX and Recurrence
 Asthma, Exercise-Induced Antibodies  >3 publications with EPX and Asthma, Exercise-Induced
 Adenocarcinoma Antibodies  >3 publications with EPX and Adenocarcinoma
Organs/Tissues associated with EPX native protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >145 publications with EPX and Blood
 Bone Antibodies  >3 publications with EPX and Bone
 Bone Marrow Antibodies  >2 publications with EPX and Bone Marrow
 Mixed Antibodies  >1 publications with EPX and Mixed
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