Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Native Protein rightarrow GPT  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • FAM63A Antibody
 • 5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2) Recombinant Protein
 • ACE ELISA Kit
 • Glutamate GluR3B Antibody
 • Streptococcus pneumoniae Antibody
 • PDP1 Antibody
 • Tartrate Resistant Acid Phosphatase 5a (TRAP 5a) ELISA Kit
 • Cluster of Differentiation 226 (CD226) ELISA Kit
 • BMS1L Antibody
 • Nitric oxide (NO) ELISA Kit
 • KCNJ2 Antibody
 • Irak4 Blocking Peptide
 • CD11c (ITGAX) Antibody
 • Goat anti Human IgA (alpha chain) Secondary Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

GPT native protein :: Glutamate Pyruvate Transaminase (GPT) Native Protein

Scan QR to view Datasheet Catalog #    MBS318111 GPT native protein
Unit / Price
  DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutamate Pyruvate Transaminase (GPT), Native Protein

 Also Known As   

GPT

 Product Synonym Names    Glutamate-Pyruvate Transaminase
 Product Gene Name   

GPT native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 8; NC_000008.10 (145729465..145732555). Location: 8q24.3
 OMIM    138200
 3D Structure    ModBase 3D Structure for P24298
Section Bar
 Host    Human Heart
Section Bar
 Specificity    Glutamate Pyruvate Transaminase (GPT)
 Purity/Purification    Ammonia sulphate suspension
 Form/Format    Purified, Liquid
 Concentration    Activity: 301 Units/ml @ 37oC measured on Dupont ACA
Protein: 9.2mg/ml (Coomassie)
Specific Activity: 32.7 Units/mg protein (lot specific)
Section Bar
 Inactivation    Not applicable
 Contaminants    GOT - 0.6%
ALP - <0.004%
GGT - <0.016%
 Buffer    Ammonia sulfate suspension
 Preservative    No
 Warnings    The donors have been tested and found to be negative for HBsAg, HCV, HIV 1 & 2, syphilis and HIV-1 Antigen by currently approved FDA methods. We certify this to be true to the best of our knowledge. However, because no test method can offer comp
Section Bar
 Preparation and Storage    Store at 2 to 8 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of GPT native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for GPT native protein

   One unit will catalyze the transamination of one micromole of L-alanine to alpha-ketoglutarate, forming L-glutamate and pyruvate per minute at 37 degree C and pH 7.8. Measured at 340 nm as one equimolar amount of NAD produced by a coupled reaction.
 Product Categories/Family for GPT native protein    Purified Enzymes
NCBI/Uniprot data below describe general gene information for GPT. It may not necessarily be applicable to this product.
 NCBI GI #    1763096
 NCBI GeneID    2875
Section Bar
 UniProt Primary Accession #    P24298 [Other Products]
 UniProt Secondary Accession #    P78398; Q93076; B0YJ18; D3DWM7 [Other Products]
 UniProt Related Accession #    P24298 [Other Products]
 Molecular Weight    54,637 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    glutamate pyruvate transaminase
 NCBI Official Synonym Full Names    glutamic-pyruvate transaminase (alanine aminotransferase)
 NCBI Official Symbol    GPT [Similar Products]
 NCBI Official Synonym Symbols   
AAT1; ALT1; GPT1
[Similar Products]
 NCBI Protein Information    alanine aminotransferase 1; GPT 1; OTTHUMP00000228783; glutamic-alanine transaminase 1; glutamic--alanine transaminase 1; glutamic--pyruvic transaminase 1; glutamate pyruvate transaminase 1
 UniProt Protein Name    Alanine aminotransferase 1
 UniProt Synonym Protein Names   
Glutamate pyruvate transaminase 1; GPT 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1
 Protein Family    Alanine aminotransferase
 UniProt Gene Name    GPT [Similar Products]
 UniProt Synonym Gene Names    AAT1; GPT1 [Similar Products]
 UniProt Entry Name    ALAT1_HUMAN
Section Bar
 NCBI Summary for GPT    This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.
Section Bar
 UniProt Comments for GPT    Function: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles

Catalytic activity: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactor: Pyridoxal phosphate.

Pathway: Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.

Subunit structure: Homodimer.

Subcellular location: Cytoplasm.

Tissue specificity: Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue. Ref.8

Induction: By glucocorticoids.

Sequence similarities: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
Table BarTOPTable Bar
 Research Articles on GPT    1. Study confirmed significant and independent associations of GGT and ALT with MetS in adult Chinese people.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with GPT native proteinDiseases associated with GPT native protein
 Products by Pathway  Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies  Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Alanine Biosynthesis II Pathway antibodies  Alanine Biosynthesis II Pathway Diagram
 Alanine Degradation III Pathway antibodies  Alanine Degradation III Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >862 publications with GPT and Liver Diseases
 Neoplasms Antibodies  >438 publications with GPT and Neoplasms
 Poisoning Antibodies  >358 publications with GPT and Poisoning
 Hepatitis Antibodies  >328 publications with GPT and Hepatitis
 Drug-Induced Liver Injury Antibodies  >314 publications with GPT and Drug-Induced Liver Injury
 Respiratory Tract Diseases Antibodies  >220 publications with GPT and Respiratory Tract Diseases
 Cardiovascular Diseases Antibodies  >200 publications with GPT and Cardiovascular Diseases
 Urologic Diseases Antibodies  >195 publications with GPT and Urologic Diseases
 Pneumonia Antibodies  >183 publications with GPT and Pneumonia
 Liver Neoplasms Antibodies  >159 publications with GPT and Liver Neoplasms
Organs/Tissues associated with GPT native protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1623 publications with GPT and Liver
 Kidney Antibodies  >311 publications with GPT and Kidney
 Heart Antibodies  >174 publications with GPT and Heart
 Lung Antibodies  >144 publications with GPT and Lung
 Brain Antibodies  >137 publications with GPT and Brain
 Skin Antibodies  >124 publications with GPT and Skin
 Intestine Antibodies  >77 publications with GPT and Intestine
 Mixed Antibodies  >69 publications with GPT and Mixed
 Stomach Antibodies  >55 publications with GPT and Stomach
 Pancreas Antibodies  >36 publications with GPT and Pancreas
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions