NP_415349.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
NCBI Official Full Name
Isoaspartyl peptidase
NCBI Protein Information
Isoaspartyl peptidase
UniProt Protein Name
Isoaspartyl peptidase
UniProt Synonym Protein Names
Beta-aspartyl-peptidase; EcAIII; Isoaspartyl dipeptidaseCleaved into the following 2 chains:Isoaspartyl peptidase subunit alpha; Isoaspartyl peptidase subunit beta
UniProt Synonym Gene Names
UniProt Entry Name
IAAA_ECOLI
NCBI Summary for iaaA
IaaA is cleaved before Thr179 to expose N-terminal nucleophile and to produce two subunits. [More information is available at EcoGene: EG12407]. Asparaginase III is first synthesized as a proenzyme which is autocatalytically cleaved post-translationally into two smaller polypeptides. [More information is available at EcoCyc: EG12407].
UniProt Comments for iaaA
Degrades proteins damaged by L-isoaspartyl residue formation (also known as beta-Asp residues). Degrades L-isoaspartyl-containing di- and maybe also tripeptides. Also has L-asparaginase activity, although this may not be its principal function.
Research Articles on iaaA
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Products associated with iaaA active protein
Pathways associated with iaaA active protein
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