Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Native Protein rightarrow LDL  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • glucosidase, alpha; acid (GAA) ELISA Kit
 • Chenodeoxycholic acid (CDCA) Antibody
 • 4E-BP1 (Ab-36) Antibody
 • Phospho-IRS2 (Y978) Antibody
 • UCHL1 ELISA Kit
 • PKN1 (PKIN1) ELISA Kit
 • Interleukin 2 (IL-2) ELISA Kit
 • Double Stranded DNA (dsDNA) Antibody
 • C1QA Antibody
 • myomesin family, member 3 (MYOM3) ELISA Kit
 • 11 beta hydroxysteroid dehydrogenase type 1 (11beta-HSD1) (H... ELISA Kit
 • Kinaseinsert Domain Receptor-VEGFR2 (KDR) ELISA Kit
 • sCD163-Soluble Haemoglobin Scavenger Receptor ELISA Kit
 • fibrinogen antiserum (FGA) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

LDL native protein :: Low Density Lipoprotein Native Protein

Scan QR to view Datasheet Catalog #    MBS143113 LDL native protein
Unit / Price
10 mg  /  $180 +1 FREE 8GB USB
100 mg  /  $455 +1 FREE 8GB USB
1 g  /  $2,750 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Low Density Lipoprotein (LDL), Native Protein

★Popular Item★
 Also Known As   

Low Density Lipoprotein

 Product Synonym Names    LDL Human; Low-Density Lipoprotein Human; Low Density Lipoprotein; LDL
 Product Gene Name   

LDL native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Host    Human Plasma
Section Bar
 Concentration    1gr/16.95ml (lot specific)
Section Bar
 Physical Appearance    Yellow to orange liquid.
 Human Virus Test    Starting material donor tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies and Syphilis.
Section Bar
 Preparation and Storage    Human LDL although stable at 4 degree C for 1 week, should be stored below -15 degree C (short term i.e. < 3 months) and below -70 degree C for long term.Human LDL can be further diluted with saline + 15% sucrose.
 Other Notes    Small volumes of LDL native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for LDL native protein

   Description: Human Low Density Lipoprotein (LDL) produced in Human plasma.

Introduction: LDL is a low-density lipoprotein that transports cholesterol and triglycerides from the liver to peripheral tissues. LDL (like all lipoproteins) facilitates the movement of fats and cholesterol within the water based solution of the blood stream. Each natural LDL particle contains a single Apo B-100 molecule (apolipoprotein B-100 is a protein with 4536 amino acid residues) that circulates the fatty acids and keeps them soluble in the aqueous environment. Additionally, the LDL core is highly-hydrophobic, consisting of linoleate (a polyunsaturated fatty acid) and about 1500 esterified cholesterol molecules. This core is enclosed by a shell of phospholipids and unesterified cholesterol in addition to a single copy of B-100 large protein (514 kD). Even though the LDL particles are approximately 22 nm in diameter and have a mass of about 3 million Daltons, they have a mass and size distribution since the LDL particles contain a varying number of fatty acids. LDL receptors are synthesized and placed in the plasma membrane when a cell requires cholesterol. The LDL receptors scatter freely until they link to clathrin-coated pits. LDL particles in the blood stream attach to these extracellular LDL receptors. The clathrin-coated pits at that time form vesicles that are endocytosed into the cell. Once the clathrin coat is dropped, the vesicles transport the LDL and their receptors to early endosomes, onto late endosomes to lysosomes. At this point the cholesterol esters in the LDL are hydrolysed. The LDL receptors are recovered back to the plasma membrane. Since LDLs convey cholesterol to the arteries and can be retained there by arterial proteoglycans initializing the formation of plaques, increased levels are linked to atherosclerosis, and thus heart attack, stroke, and peripheral vascular disease. And so, cholesterol within LDL lipoproteins is habitually called "bad" cholesterol. This is a misconception since the cholesterol transported on LDL is the same as the one transported on other lipoprotein particles, it is in itself not "bad", rather it is how and where the cholesterol is being transported, and in what amounts ultimately, which causes adverse effects. HDL / LDL ratio can give an indication of risk for arteriosclerosis.
 Product Categories/Family for LDL native protein    RECOMBINANT & NATURAL PROTEINS; Natural Proteins
NCBI/Uniprot data below describe general gene information for LDL. It may not necessarily be applicable to this product.
 NCBI GI #    306411097
 NCBI Accession #    ADM85894.1 [Other Products]
Table BarTOPTable Bar
 NCBI Official Full Name    low density lipoprotein, partial
 UniProt Protein Name    Low density lipoprotein
 UniProt Synonym Protein Names   
Low density lipoprotein
 Protein Family    Low density lipoprotein receptor adapter protein
 UniProt Gene Name    LDLR [Similar Products]
 UniProt Entry Name    E1B4T0_HUMAN
Section Bar
 NCBI Summary for LDL    The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions