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MBP native protein

Scan QR to view Datasheet Catalog #    MBS537513 MBP native protein
Unit / Price
1 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MBP, Native Protein

★Popular Item★
 Also Known As   

MBP protein

 Product Synonym Names    Myelin Basic Protein
 Product Gene Name   

MBP native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    159430
 3D Structure    ModBase 3D Structure for P02686
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 Host    Human
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 Purity/Purification    > 95% pure
 Form/Format    Lyophilized from 10 mM HCl, with 0.1% NaN3.DO NOT reconstitute with PBS buffer!
 Concentration    1.0 mg per vial; lyophilized (lot specific)
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 Source Note    Human brain
 Protein Type    Native
 Biological Significance    Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the central nervous system (CNS). The human gene for MBP is on chromosome 18, the protein localizes to the CNS and to various cells of the hematopoietic system. The pool of MBP in the central nervous system is very diverse, with several splice variants being expressed.
 Biohazard Information    Donor samples were tested and found to be negative for HBsAg, HCV, HIV-1 and 2 antibodies, and syphilis. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
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 Preparation and Storage    Lyophilized product store at  -20 degree C. Avoid repeated Freeze/Thaw cycles
 Other Notes    Small volumes of MBP native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MBP native protein

   Purified native Human MBP protein
 Product Categories/Family for MBP native protein    Neuroscience; Native Protein
 Applications Tested/Suitable for MBP native protein   

User optimized

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NCBI/Uniprot data below describe general gene information for MBP. It may not necessarily be applicable to this product.
 NCBI GI #    17378805
 NCBI GeneID    4155
 NCBI Accession #    P02686.3 [Other Products]
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 UniProt Primary Accession #    P02686 [Other Products]
 UniProt Secondary Accession #    Q15337; Q15338; Q15339; Q15340; A4FU54; A6NI84; A8MY86; A8MYL4; B3KY66; B7ZKS2; B7ZKS4 [Other Products]
 UniProt Related Accession #    P02686 [Other Products]
 Molecular Weight    17,343 Da
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 NCBI Official Full Name    Myelin basic protein
 NCBI Official Synonym Full Names    myelin basic protein
 NCBI Official Symbol    MBP [Similar Products]
 NCBI Protein Information    Golli-MBP; myelin basic protein
 UniProt Protein Name    Myelin basic protein
 UniProt Synonym Protein Names   
Myelin A1 protein; Myelin membrane encephalitogenic protein
 Protein Family    Myelin basic protein
 UniProt Gene Name    MBP [Similar Products]
 UniProt Synonym Gene Names    MBP [Similar Products]
 UniProt Entry Name    MBP_HUMAN
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 NCBI Summary for MBP    The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MBP    MBP: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Homodimer. Isoform 3 exists as a homodimer. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Belongs to the myelin basic protein family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 18q23

Cellular Component: internode region of axon; compact myelin; cell soma; plasma membrane; nucleus

Molecular Function: protein binding; protease binding; structural constituent of myelin sheath

Biological Process: response to mercury ion; myelination; synaptic transmission; substantia nigra development; central nervous system development; response to toxin; immune response; negative regulation of axonogenesis; axon ensheathment; response to progesterone stimulus; aging
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 Research Articles on MBP    1. Negatively charged actin and calmodulin (CaM), as well as basic histone H1.3, inhibit MBP hydrolysis by competing with the proteasome and MBP, respectively, for binding their counterpart.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MBP native proteinDiseases associated with MBP native protein
 Products by Pathway  Pathway Diagram
 Glial Cell Differentiation Pathway antibodies  Glial Cell Differentiation Pathway Diagram
 MAPK Cascade Pathway antibodies  MAPK Cascade Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2709 publications with MBP and Nervous System Diseases
 Demyelinating Diseases Antibodies  >1982 publications with MBP and Demyelinating Diseases
 Brain Diseases Antibodies  >1743 publications with MBP and Brain Diseases
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >1197 publications with MBP and Encephalomyelitis, Autoimmune, Experimental
 Cardiovascular Diseases Antibodies  >699 publications with MBP and Cardiovascular Diseases
 Inflammation Antibodies  >501 publications with MBP and Inflammation
 Hypertension Antibodies  >416 publications with MBP and Hypertension
 Necrosis Antibodies  >263 publications with MBP and Necrosis
 Heart Diseases Antibodies  >193 publications with MBP and Heart Diseases
 Kidney Diseases Antibodies  >153 publications with MBP and Kidney Diseases
Organs/Tissues associated with MBP native protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3680 publications with MBP and Blood
 Brain Antibodies  >1944 publications with MBP and Brain
 Nerve Antibodies  >1441 publications with MBP and Nerve
 Heart Antibodies  >690 publications with MBP and Heart
 Spinal Cord Antibodies  >689 publications with MBP and Spinal Cord
 Kidney Antibodies  >269 publications with MBP and Kidney
 Muscle Antibodies  >248 publications with MBP and Muscle
 Spleen Antibodies  >243 publications with MBP and Spleen
 Lymph Node Antibodies  >240 publications with MBP and Lymph Node
 Lymph Antibodies  >240 publications with MBP and Lymph
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