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Mbp native protein :: Myelin Basic Protein >90% Pure Native Protein

Scan QR to view Datasheet Catalog #    MBS318337 Mbp native protein
Unit / Price
1 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Myelin Basic Protein >90% Pure (Mbp), Native Protein

 Also Known As   

Myelin Basic Protein

 Product Synonym Names    Contains 18.5kDa and 14.2kDa isoforms and their dimers (13.5% SDS-PAGE non-reducing conditions)
 Product Gene Name   

Mbp native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 18; NC_005117.2 (78943608..79057329). Location: 18q
 3D Structure    ModBase 3D Structure for P02688
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 Host    Human brain
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 Specificity    Myelin Basic Protein >90% Pure
 Purity/Purification    >95% pure (SDS-PAGE)
 Form/Format    Purified, Lyophilized
Reconstitute with 10mM HCl
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 Inactivation    Not applicable
 Buffer    Not applicable
 Preservative    No
 Lyophilized    Yes
 Warnings    Blood sample from the tissue donor tested negative for HIV 1, HIV 2, HCV antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially in
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 Preparation and Storage    Store at -20 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Mbp native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for Mbp native protein    Purified Neuroscience Reagents
 Application Notes for Mbp native protein    Immunoreactivity is checked using polyclonal and monoclonal antibodies against MBP. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not
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NCBI/Uniprot data below describe general gene information for Mbp. It may not necessarily be applicable to this product.
 NCBI GI #    70166270
 NCBI GeneID    24547
 NCBI Accession #    NP_001020465.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001025294.1 [Other Products]
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 UniProt Primary Accession #    P02688 [Other Products]
 UniProt Secondary Accession #    Q505J1; Q8R4K6; Q9Z1J4; Q9Z1J5; Q9Z1J6 [Other Products]
 UniProt Related Accession #    P02688; Q5XFW1 [Other Products]
 Molecular Weight    21,502 Da [Similar Products]
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 NCBI Official Full Name    myelin basic protein isoform 4
 NCBI Official Synonym Full Names    myelin basic protein
 NCBI Official Symbol    Mbp [Similar Products]
 NCBI Official Synonym Symbols   
Mbps
[Similar Products]
 NCBI Protein Information    Golli-Mbp; myelin basic protein; MBP S; myelin basic protein S; myelin basic protein Golli-mbp; Golli-Mbp; myelin basic protein; myelin basic protein S
 UniProt Protein Name    Myelin basic protein S
 Protein Family    Myelin basic protein
 UniProt Gene Name    Mbp [Similar Products]
 UniProt Entry Name    MBP_RAT
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 NCBI Summary for Mbp    The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq]
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 UniProt Comments for Mbp    Function: Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane

Subunit structure: Homodimer

Subcellular location: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note: Cytoplasmic side of myelin.

Tissue specificity: Found in both the central and the peripheral nervous system.

Post-translational modification: As in other animals, several charge isomers may be produced as a result of optional post-translatonial modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues.Arg-131 was found to be 44% monomethylated and 11% symmetrically dimethylated.

Sequence similarities: Belongs to the myelin basic protein family.
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Product References and Citations for Mbp native protein

   • Diebler, G.E., (1972), Preparative Biochemistry, 2(2) 139-165.
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 Research Articles on Mbp    1. MBP synthesis is regulated by hnRNP-K and integrin activation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Mbp native proteinDiseases associated with Mbp native protein
 Products by Pathway  Pathway Diagram
 MAPK Cascade Pathway antibodies  MAPK Cascade Pathway Diagram
 Disease Name  Pubmed Publications
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >1100 publications with Mbp and Encephalomyelitis, Autoimmune, Experimental
 Inflammation Antibodies  >399 publications with Mbp and Inflammation
 Neoplasms Antibodies  >389 publications with Mbp and Neoplasms
 Mental Disorders Antibodies  >129 publications with Mbp and Mental Disorders
 Neurodegenerative Diseases Antibodies  >89 publications with Mbp and Neurodegenerative Diseases
 Leukemia Antibodies  >80 publications with Mbp and Leukemia
 Intestinal Diseases Antibodies  >78 publications with Mbp and Intestinal Diseases
 Glioma Antibodies  >68 publications with Mbp and Glioma
 Pain Antibodies  >61 publications with Mbp and Pain
 Edema Antibodies  >51 publications with Mbp and Edema
Organs/Tissues associated with Mbp native protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1551 publications with Mbp and Brain
 Kidney Antibodies  >233 publications with Mbp and Kidney
 Spleen Antibodies  >224 publications with Mbp and Spleen
 Muscle Antibodies  >213 publications with Mbp and Muscle
 Eye Antibodies  >98 publications with Mbp and Eye
 Dorsal Root Ganglion Antibodies  >35 publications with Mbp and Dorsal Root Ganglion
 Placenta Antibodies  >30 publications with Mbp and Placenta
 Ovary Antibodies  >28 publications with Mbp and Ovary
 Prostate Antibodies  >24 publications with Mbp and Prostate
 Adrenal Gland Antibodies  >20 publications with Mbp and Adrenal Gland
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