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MPO native protein :: Myeloperoxidase Native Protein

Scan QR to view Datasheet Catalog #    MBS537630 MPO native protein
Unit / Price
0.1 mg  /  $370 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Myeloperoxidase (MPO), Native Protein

 Also Known As   

Myeloperoxidase protein

 Product Synonym Names    89 kDa myeloperoxidase protein; MPO protein; 84 kDa myeloperoxidase protein; Myeloperoxidase protein; Myeloperoxidase light chain proteinMyeloperoxidase heavy chain
 Product Gene Name   

MPO native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    254600
 3D Structure    ModBase 3D Structure for P05164
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 Host    Human
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 Purity/Purification    > 98% pure
 Form/Format    50mM NaC2H3O2, pH 6.0, 100M NaCl.
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 Source Note    Human neutrophils
 Protein Type    Native
 Biological Significance    Myeloperoxidase is a heme protein which catalyzes oxidations by hydrogen peroxide, including MPO- chloride mediated killing of microbes and tumor cells, inactivation of hemotactic factors, crosslinking of proteins and inclination of proteins.
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of MPO native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MPO native protein

   Purified native Human Myeloperoxidase protein
 Product Categories/Family for MPO native protein    Proteases, Inhibitors, & Enzymes; Native Protein
 Applications Tested/Suitable for MPO native protein   

User optimized

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NCBI/Uniprot data below describe general gene information for MPO. It may not necessarily be applicable to this product.
 NCBI GI #    4557759
 NCBI GeneID    4353
 NCBI Accession #    NP_000241.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000250.1 [Other Products]
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 UniProt Primary Accession #    P05164 [Other Products]
 UniProt Secondary Accession #    Q14862; Q4PJH5; Q9UCL7; A1L4B8 [Other Products]
 UniProt Related Accession #    P05164 [Other Products]
 Molecular Weight    87,248 Da [Similar Products]
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 NCBI Official Full Name    myeloperoxidase
 NCBI Official Synonym Full Names    myeloperoxidase
 NCBI Official Symbol    MPO [Similar Products]
 NCBI Protein Information    myeloperoxidase
 UniProt Protein Name    Myeloperoxidase
 Protein Family    Myeloperoxidase
 UniProt Gene Name    MPO [Similar Products]
 UniProt Synonym Gene Names    MPO [Similar Products]
 UniProt Entry Name    PERM_HUMAN
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 NCBI Summary for MPO    Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
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 UniProt Comments for MPO    MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.11.2.2; Oxidoreductase

Chromosomal Location of Human Ortholog: 17q23.1

Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule

Molecular Function: heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding

Biological Process: response to food; respiratory burst during defense response; removal of superoxide radicals; hydrogen peroxide catabolic process; response to mechanical stimulus; defense response; response to yeast; response to lipopolysaccharide; response to oxidative stress; defense response to fungus; negative regulation of apoptosis; aging

Disease: Myeloperoxidase Deficiency; Alzheimer Disease
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 Research Articles on MPO    1. MPO-mediated oxidation may be implicated in the mechanism that leads to amyloid deposition in the atherosclerotic plaques in vivo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MPO native proteinPathways associated with MPO native protein
 Reference Product  PubMed Publications
 PTGS1 native protein  >31 publications with MPO and PTGS1
 MYB native protein  >12 publications with MPO and MYB
 JAK2 native protein  >5 publications with MPO and JAK2
 IL23A native protein  >1 publications with MPO and IL23A
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Vitamin B12 Metabolism Pathway antibodies  Vitamin B12 Metabolism Pathway Diagram
 Amb2 Integrin Signaling Pathway antibodies  Amb2 Integrin Signaling Pathway Diagram
Diseases associated with MPO native proteinOrgans/Tissues associated with MPO native protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2738 publications with MPO and Inflammation
 Cardiovascular Diseases Antibodies  >2117 publications with MPO and Cardiovascular Diseases
 Necrosis Antibodies  >1545 publications with MPO and Necrosis
 Lung Diseases Antibodies  >1232 publications with MPO and Lung Diseases
 Reperfusion Injury Antibodies  >860 publications with MPO and Reperfusion Injury
 Colitis Antibodies  >697 publications with MPO and Colitis
 Kidney Diseases Antibodies  >653 publications with MPO and Kidney Diseases
 Edema Antibodies  >641 publications with MPO and Edema
 Heart Diseases Antibodies  >460 publications with MPO and Heart Diseases
 Hemorrhage Antibodies  >436 publications with MPO and Hemorrhage
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5072 publications with MPO and Blood
 Lung Antibodies  >1531 publications with MPO and Lung
 Kidney Antibodies  >748 publications with MPO and Kidney
 Brain Antibodies  >608 publications with MPO and Brain
 Bone Antibodies  >393 publications with MPO and Bone
 Bone Marrow Antibodies  >310 publications with MPO and Bone Marrow
 Eye Antibodies  >95 publications with MPO and Eye
 Lymph Node Antibodies  >90 publications with MPO and Lymph Node
 Thyroid Antibodies  >84 publications with MPO and Thyroid
 Embryonic Tissue Antibodies  >41 publications with MPO and Embryonic Tissue
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