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MB native protein :: Myoglobin Native Protein

Scan QR to view Datasheet Catalog #    MBS143116 MB native protein
Unit / Price
0.2 mg  /  $180 +1 FREE 8GB USB
1 mg  /  $455 +1 FREE 8GB USB
10 mg  /  $2,090 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Myoglobin (MB), Native Protein

★Popular Item★
 Also Known As   

Human Myoglobin

 Product Synonym Names    Myoglobin Human; Myoglobin Human; Myoglobin; MB; PVALB; MGC13548; Myoglobin
 Product Gene Name   

MB native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    160000
 3D Structure    ModBase 3D Structure for P02144
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 Host    Human Cardiac Tissues
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 Purity/Purification    Greater than 96.0%.
 Form/Format    The protein solution is in 0.05M phosphate buffer containing 0.15M NaCl and 0.09% NaN3 pH 7.5. Filtered through a 0.2 uM membrane.
Sterile Filtered red solution.
 Concentration    7.35 mg/ml (lot specific)
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 Human Virus Test    Starting material donor tested and certified negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies. Product tested and found negative for HTLV antibodies.
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 Preparation and Storage    Human Myoglobin should be stored at 2-8 degree C.
 Other Notes    Small volumes of MB native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MB native protein

   Description: Human Myoglobin produced in Human Cardiac Tissues having a molecular mass of 17.5kDa. Myoglobin is released from recently injured myocardial cells within a few hours of Infarction. Peak levels are reached more quickly than CK-MB or Troponin complex.

Introduction: Myoglobin is a member of the globin superfamily and can be found in skeletal and cardiac muscles. It is a haemoprotein that contributs to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. Myoglobin has a single-chain globular structure of 153 amino acids, containing a heme prosthetic group (iron-containing porphyrin) in the core around which the remaining apoprotein folds. Myoglobin has 8 alpha helices and a hydrophobic core. Myoglobin's molecular weight is 16.7 kDa, and it is the primary oxygen-carrying pigment of muscle tissues. The binding of oxygen in myoglobin is different from the cooperative oxygen binding in hemoglobin, since positive collaboration is a property of multimeric/oligomeric proteins only. Instead, the binding of oxygen by myoglobin is uninfluenced by the oxygen pressure in the surrounding tissue. Myoglobin is frequently referred to as having an "instant binding tenacity" to oxygen given its hyperbolic oxygen dissociation curve. Different organisms are able to hold their breaths longer due to high concentrations of myoglobin in their muscle cells. Myoglobin is responsible for the pigments that make meat red. The color of the meat is partly determined by the charge of the iron atom in myoglobin and the oxygen attached to it. Myoglobin is found in Type I muscle, Type II A and Type II B, but it is mostly deemed that myoglobin is not found in smooth muscle. Myoglobin is discharged from damaged muscle tissue (rhabdomyolysis), which contains very high concentrations of myoglobin. Even though the released myoglobin is filtered by the kidneys, it is toxic to the renal tubular epithelium and thus may cause acute renal failure.
 Product Categories/Family for MB native protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Myoglobin
NCBI/Uniprot data below describe general gene information for MB. It may not necessarily be applicable to this product.
 NCBI GI #    4885477
 NCBI GeneID    4151
 NCBI Accession #    NP_005359.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005368.2 [Other Products]
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 UniProt Primary Accession #    P02144 [Other Products]
 UniProt Secondary Accession #    Q52H51; Q5THY7 [Other Products]
 UniProt Related Accession #    P02144 [Other Products]
 Molecular Weight    17,184 Da [Similar Products]
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 NCBI Official Full Name    myoglobin
 NCBI Official Synonym Full Names    myoglobin
 NCBI Official Symbol    MB [Similar Products]
 NCBI Official Synonym Symbols   
PVALB; myoglobgin
[Similar Products]
 NCBI Protein Information    myoglobin
 UniProt Protein Name    Myoglobin
 Protein Family    Myoglobin
 UniProt Gene Name    MB [Similar Products]
 UniProt Entry Name    MYG_HUMAN
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 NCBI Summary for MB    This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MB    MB: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. Belongs to the globin family.

Protein type: Carrier

Chromosomal Location of Human Ortholog: 22q13.1

Molecular Function: iron ion binding; heme binding; oxygen binding; oxygen transporter activity

Biological Process: slow-twitch skeletal muscle fiber contraction; response to hydrogen peroxide; oxygen transport; heart development; response to hypoxia; brown fat cell differentiation; response to hormone stimulus; enucleate erythrocyte differentiation
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 Research Articles on MB    1. Data show that chimeric neuroglobin and myoglobin were generated by swapping a regulatory segment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MB native proteinPathways associated with MB native protein
 Reference Product  PubMed Publications
 ALB native protein  >14 publications with MB and ALB
 HBB native protein  >13 publications with MB and HBB
 CKM native protein  >11 publications with MB and CKM
 HPR native protein  >11 publications with MB and HPR
 TNNT2 native protein  >5 publications with MB and TNNT2
 TNNI3 native protein  >2 publications with MB and TNNI3
 VCAM1 native protein  >2 publications with MB and VCAM1
 PGAM2 native protein  >1 publications with MB and PGAM2
 Products by Pathway  Pathway Diagram
 Effects Of Nitric Oxide Pathway antibodies  Effects Of Nitric Oxide Pathway Diagram
Diseases associated with MB native proteinOrgans/Tissues associated with MB native protein
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >5994 publications with MB and Heart Diseases
 Myocardial Infarction Antibodies  >3948 publications with MB and Myocardial Infarction
 Congenital Abnormalities Antibodies  >2238 publications with MB and Congenital Abnormalities
 Disease Models, Animal Antibodies  >1441 publications with MB and Disease Models, Animal
 Necrosis Antibodies  >1416 publications with MB and Necrosis
 Adenocarcinoma Antibodies  >1015 publications with MB and Adenocarcinoma
 Lung Diseases Antibodies  >969 publications with MB and Lung Diseases
 Inflammation Antibodies  >917 publications with MB and Inflammation
 Lung Neoplasms Antibodies  >854 publications with MB and Lung Neoplasms
 Kidney Diseases Antibodies  >576 publications with MB and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >5289 publications with MB and Heart
 Muscle Antibodies  >3635 publications with MB and Muscle
 Vascular Antibodies  >2285 publications with MB and Vascular
 Lung Antibodies  >1670 publications with MB and Lung
 Liver Antibodies  >1190 publications with MB and Liver
 Nerve Antibodies  >854 publications with MB and Nerve
 Prostate Antibodies  >640 publications with MB and Prostate
 Eye Antibodies  >555 publications with MB and Eye
 Mouth Antibodies  >356 publications with MB and Mouth
 Embryonic Tissue Antibodies  >319 publications with MB and Embryonic Tissue
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