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BGLAP native protein :: Osteocalcin Native Protein

Scan QR to view Datasheet Catalog #    MBS537417 BGLAP native protein
Unit / Price
0.1 mg  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Osteocalcin (BGLAP), Native Protein

 Also Known As   

Osteocalcin protein (Bovine)

 Product Synonym Names    Bovine Osteocalcin Protein
 Product Gene Name   

BGLAP native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    112260
 3D Structure    ModBase 3D Structure for P02818
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 Host    Bovine
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 Purity/Purification    > 98% pure
 Form/Format    Supplied as a liquid with 50% Glycerol/H2O (vol/vol).
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 Source Note    Bovine plasma
 Biological Significance    Osteocalcin, also known as Bone-Gla-Protein (BGP), is a single chain (Mr=5800) vitamin K dependent protein produced by osteoblasts and found in high concentrations in bone. Post-translational modification by a vitamin K dependent carboxylase produces three g-carboxyglutamic acid residues at positions 17, 21 and 24.
 Biohazard Information    Donor samples were tested and found to be negative for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
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 Preparation and Storage    Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
 Other Notes    Small volumes of BGLAP native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for BGLAP native protein

   Purified native Bovine Osteocalcin protein
 Product Categories/Family for BGLAP native protein    Nutrition & Metabolism; Native Protein
 Applications Tested/Suitable for BGLAP native protein   

User optimized

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NCBI/Uniprot data below describe general gene information for BGLAP. It may not necessarily be applicable to this product.
 NCBI GI #    40316933
 NCBI GeneID    632
 NCBI Accession #    NP_954642.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_199173.4 [Other Products]
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 UniProt Primary Accession #    P02818 [Other Products]
 UniProt Secondary Accession #    Q5TCK6 [Other Products]
 UniProt Related Accession #    P02818 [Other Products]
 Molecular Weight    5.8 kDa [Similar Products]
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 NCBI Official Full Name    osteocalcin preproprotein
 NCBI Official Synonym Full Names    bone gamma-carboxyglutamate (gla) protein
 NCBI Official Symbol    BGLAP [Similar Products]
 NCBI Official Synonym Symbols   
OC; BGP; OCN
[Similar Products]
 NCBI Protein Information    osteocalcin
 UniProt Protein Name    Osteocalcin
 UniProt Synonym Protein Names   
Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein
 Protein Family    Osteocalcin
 UniProt Gene Name    BGLAP [Similar Products]
 UniProt Synonym Gene Names    BGP [Similar Products]
 UniProt Entry Name    OSTCN_HUMAN
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 NCBI Summary for BGLAP    This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
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 UniProt Comments for BGLAP    osteocalcin: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Belongs to the osteocalcin/matrix Gla protein family.

Protein type: Secreted; Cell development/differentiation; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: Golgi apparatus; extracellular space; rough endoplasmic reticulum; dendrite; cytoplasm; perikaryon

Molecular Function: structural constituent of bone; hydroxyapatite binding; calcium ion binding; structural molecule activity

Biological Process: response to drug; response to gravity; regulation of bone resorption; response to glucocorticoid stimulus; cell aging; response to testosterone stimulus; bone mineralization; osteoblast development; odontogenesis; osteoblast differentiation; response to ethanol; response to vitamin D; regulation of osteoclast differentiation; response to vitamin K; response to estrogen stimulus; response to mechanical stimulus; response to zinc ion; response to hydroxyisoflavone; response to activity; cell adhesion; skeletal development; regulation of bone mineralization
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 Research Articles on BGLAP    1. in type 1 diabetes of long duration, OC serum levels are inversely associated with HbA1c and BMI, supporting the hypothesis that a poor glycemic control can affect osteoblast function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BGLAP native proteinPathways associated with BGLAP native protein
 Reference Product  PubMed Publications
 RUNX2 native protein  >49 publications with BGLAP and RUNX2
 SPP1 native protein  >24 publications with BGLAP and SPP1
 BMP2 native protein  >13 publications with BGLAP and BMP2
 PTH native protein  >3 publications with BGLAP and PTH
 ATF4 native protein  >2 publications with BGLAP and ATF4
 ADIPOQ native protein  >1 publications with BGLAP and ADIPOQ
 LEP native protein  >1 publications with BGLAP and LEP
 PTHLH native protein  >1 publications with BGLAP and PTHLH
 Products by Pathway  Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Interleukin-11 Signaling Pathway antibodies  Interleukin-11 Signaling Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
 Regulation Of Retinoblastoma Protein Pathway antibodies  Regulation Of Retinoblastoma Protein Pathway Diagram
 Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway antibodies  Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway Diagram
Diseases associated with BGLAP native proteinOrgans/Tissues associated with BGLAP native protein
 Disease Name  Pubmed Publications
 Bone Diseases Antibodies  >11 publications with BGLAP and Bone Diseases
 Osteoporosis Antibodies  >9 publications with BGLAP and Osteoporosis
 Inflammation Antibodies  >6 publications with BGLAP and Inflammation
 Nervous System Diseases Antibodies  >4 publications with BGLAP and Nervous System Diseases
 Insulin Resistance Antibodies  >3 publications with BGLAP and Insulin Resistance
 Calcinosis Antibodies  >3 publications with BGLAP and Calcinosis
 Cardiovascular Diseases Antibodies  >2 publications with BGLAP and Cardiovascular Diseases
 Kidney Diseases Antibodies  >2 publications with BGLAP and Kidney Diseases
 Pain Antibodies  >2 publications with BGLAP and Pain
 Weight Loss Antibodies  >1 publications with BGLAP and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >95 publications with BGLAP and Bone
 Parathyroid Antibodies  >3 publications with BGLAP and Parathyroid
 Brain Antibodies  >3 publications with BGLAP and Brain
 Prostate Antibodies  >2 publications with BGLAP and Prostate
 Lung Antibodies  >1 publications with BGLAP and Lung
 Heart Antibodies  >1 publications with BGLAP and Heart
 Intestine Antibodies  >1 publications with BGLAP and Intestine
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