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PAP native protein

Scan QR to view Datasheet Catalog #    MBS537789 PAP native protein
Unit / Price
1 mg  /  $180 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PAP, Native Protein

 Also Known As   

PAP protein (> 40% pure)

 Product Synonym Names    PAP protein; PAP antigen; Prostatic Acid Phosphatase protein
 Product Gene Name   

PAP native protein

[Similar Products]
 Matching Pairs    Antibody: PAP Clone #M01010922 (MBS530241)
Antigen: PAP (MBS537789)
Comments: Prepared from human seminal fluid. >40% pure by SDS-PAGE
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    171790
 3D Structure    ModBase 3D Structure for P15309
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 Host    Human
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 Purity/Purification    > 40% pure
 Form/Format    Supplied 0.2 micron filtered in 150mM NaCl, 9.5mM Sodium Phosphate Monobasic, 40.5mM Sodium Phosphate Dibasic, pH 7.6 with 0.05% NaN3
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 Source Note    Human seminal fluid
 Protein Type    Native
 Biological Significance    Prostatic acid phosphatase (PAP), also prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer or other diseases. The highest levels of acid phosphatase are found in metastasized prostate cancer.
 Biohazard Information    Donor samples were tested and found to be negative for  HIV I/II, and HCV antibodies, and Hepatitis B surface antigen. Nonetheless caution should be used when handling this material as there is a margin of error in all tests. This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Dry Ice Shipment    Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
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 Preparation and Storage    Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles.
 Other Notes    Small volumes of PAP native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PAP native protein

   Purified native Human PAP protein (> 40% pure)
 Product Categories/Family for PAP native protein    Cancer; Native Protein
 Applications Tested/Suitable for PAP native protein   

User optimized

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NCBI/Uniprot data below describe general gene information for PAP. It may not necessarily be applicable to this product.
 NCBI GI #    6382064
 NCBI GeneID    55
 NCBI Accession #    NP_001090.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001099.4 [Other Products]
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 UniProt Primary Accession #    P15309 [Other Products]
 UniProt Secondary Accession #    Q5FBY0; Q96KY0; Q96QK9; Q96QM0; D3DNC6 [Other Products]
 UniProt Related Accession #    P15309 [Other Products]
 Molecular Weight    51 kDa
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 NCBI Official Full Name    prostatic acid phosphatase isoform PAP
 NCBI Official Synonym Full Names    acid phosphatase, prostate
 NCBI Official Symbol    ACPP [Similar Products]
 NCBI Official Synonym Symbols   
ACP3; 5'-NT; ACP-3
[Similar Products]
 NCBI Protein Information    prostatic acid phosphatase
 UniProt Protein Name    Prostatic acid phosphatase
 UniProt Synonym Protein Names   
5'-nucleotidase (EC:; 5'-NT
 Protein Family    Papain
 UniProt Gene Name    ACPP [Similar Products]
 UniProt Synonym Gene Names    PAP; 5'-NT; TMPase [Similar Products]
 UniProt Entry Name    PPAP_HUMAN
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 NCBI Summary for PAP    This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
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 UniProt Comments for PAP    ACPP: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Belongs to the histidine acid phosphatase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC; Phosphatase; Cofactor and Vitamin Metabolism - riboflavin; EC; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: multivesicular body; extracellular space; Golgi cisterna; apical part of cell; lysosomal membrane; integral to membrane; plasma membrane; intracellular; vesicle membrane; nucleus; secretory granule; filopodium

Molecular Function: 5'-nucleotidase activity; choline binding; identical protein binding; acid phosphatase activity; protein homodimerization activity; phosphoric monoester hydrolase activity; thiamin phosphate phosphatase activity

Biological Process: thiamin metabolic process; dephosphorylation; positive regulation of adenosine receptor signaling pathway; nucleotide metabolic process; regulation of sensory perception of pain; adenosine metabolic process; purine base metabolic process
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 Research Articles on PAP    1. ACPP increases significantly in epithelial cells of ovarian carcinoma, which indicates that it may be a candidate biomarker for diagnosis of epithelia-derived ovarian cancer in women.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PAP native proteinPathways associated with PAP native protein
 Reference Product  PubMed Publications
 SLC45A3 native protein  >1 publications with PAP and SLC45A3
 KLK3 native protein  >1 publications with PAP and KLK3
 Products by Pathway  Pathway Diagram
 Riboflavin Metabolism Pathway antibodies  Riboflavin Metabolism Pathway Diagram
 Riboflavin Metabolism Pathway antibodies  Riboflavin Metabolism Pathway Diagram
Diseases associated with PAP native proteinOrgans/Tissues associated with PAP native protein
 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >9 publications with PAP and Prostatic Neoplasms
 Inflammation Antibodies  >4 publications with PAP and Inflammation
 Fibrosis Antibodies  >3 publications with PAP and Fibrosis
 Breast Neoplasms Antibodies  >3 publications with PAP and Breast Neoplasms
 Necrosis Antibodies  >3 publications with PAP and Necrosis
 Hyperplasia Antibodies  >3 publications with PAP and Hyperplasia
 Ovarian Neoplasms Antibodies  >2 publications with PAP and Ovarian Neoplasms
 Urinary Bladder Neoplasms Antibodies  >2 publications with PAP and Urinary Bladder Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with PAP and Neoplasm Metastasis
 Myocardial Infarction Antibodies  >2 publications with PAP and Myocardial Infarction
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13 publications with PAP and Blood
 Prostate Antibodies  >13 publications with PAP and Prostate
 Brain Antibodies  >6 publications with PAP and Brain
 Muscle Antibodies  >4 publications with PAP and Muscle
 Bone Antibodies  >4 publications with PAP and Bone
 Ovary Antibodies  >2 publications with PAP and Ovary
 Skin Antibodies  >2 publications with PAP and Skin
 Nerve Antibodies  >1 publications with PAP and Nerve
 Connective Tissue Antibodies  >1 publications with PAP and Connective Tissue
 Bone Marrow Antibodies  >1 publications with PAP and Bone Marrow
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