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PRTN3 native protein :: Proteinase 3 Native Protein

Scan QR to view Datasheet Catalog #    MBS537185 PRTN3 native protein
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 Product Name   

Proteinase 3 (PRTN3), Native Protein

★Popular Item★
 Also Known As   

Proteinase 3 protein

 Product Synonym Names    Proteinase 3 protein; Proteinase 3; Proteinase -3 protein; Proteinase -3
 Product Gene Name   

PRTN3 native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    177020
 3D Structure    ModBase 3D Structure for P24158
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 Host    Human
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 Purity/Purification    > 90% by SDS-electrophoresis
 Form/Format    20mM Hepes-NaOH, pH 8.0; 400mM NaCl; 0.1mM PMSF, 0.02% Lubrol; 0.1% Mircr-O-protectTM
 Concentration    0.913mg/ml (lot specific)
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 Source Note    Human neutrophils
 Protein Type    Native
 Grade    Higly Purified
 Biological Significance    Proteinase 3 is a serine proteinase with proteolytic activity towards a range of substrates. It is physiologically inhibited by alpha1-antitrypsin. The protein has been described as having antibiotic and growth-promoting properties and causing empysema when administered by tracheal insufflation..
 Biohazard Information    Warning Potentially Biohazardous Material.
Contains human source material. No known test method can offer complete assrance that infectious aganets are absent. All human source products should be handled using the same safety precautions employed when handling any potentially infectious material.
 Dry Ice Shipment    Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
 Contaminant    None detected
 Notes    Detects auto antibodies to human proteinase-3 in ELISA.
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 Preparation and Storage    Upon receipt store at -20 degree C. Ships on Dry Ice.
 Other Notes    Small volumes of PRTN3 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PRTN3 native protein

   Purified native Human Proteinase 3 protein
 Product Categories/Family for PRTN3 native protein    Immunology; Native Protein
 Applications Tested/Suitable for PRTN3 native protein   


 Application Notes for PRTN3 native protein    0.5-1 ug/ml
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NCBI/Uniprot data below describe general gene information for PRTN3. It may not necessarily be applicable to this product.
 NCBI GI #    1335280
 NCBI GeneID    5657
 NCBI Accession #    CAA39203.1 [Other Products]
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 UniProt Primary Accession #    P24158 [Other Products]
 UniProt Secondary Accession #    P15637; P18078; Q4VB08; Q4VB09; Q6LBM7; Q6LBN2; Q9UD25; Q9UQD8 [Other Products]
 UniProt Related Accession #    P24158 [Other Products]
 Molecular Weight    27,807 Da [Similar Products]
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 NCBI Official Full Name    proteinase 3
 NCBI Official Synonym Full Names    proteinase 3
 NCBI Official Symbol    PRTN3 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    myeloblastin
 UniProt Protein Name    Myeloblastin
 UniProt Synonym Protein Names   
AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen
 Protein Family    Myeloblastin
 UniProt Gene Name    PRTN3 [Similar Products]
 UniProt Synonym Gene Names    MBN; PR-3; PR3; NP-4 [Similar Products]
 UniProt Entry Name    PRTN3_HUMAN
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 UniProt Comments for PRTN3    PRTN3: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. Belongs to the peptidase S1 family. Elastase subfamily.

Protein type: EC; Cell cycle regulation; Protease

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular matrix; extracellular space; plasma membrane; cytosol

Molecular Function: enzyme binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: negative regulation of phagocytosis; collagen catabolic process; positive regulation of cell proliferation; blood coagulation; proteolysis
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 Research Articles on PRTN3    1. Anti-PR3 autoantibodies not detected in sera of patients with pulmonary tuberculosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PRTN3 native proteinDiseases associated with PRTN3 native protein
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Common Pathway Of Fibrin Clot Formation antibodies  Common Pathway Of Fibrin Clot Formation Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >7 publications with PRTN3 and Vascular Diseases
 Granulomatosis with Polyangiitis Antibodies  >7 publications with PRTN3 and Granulomatosis with Polyangiitis
 Lung Diseases Antibodies  >5 publications with PRTN3 and Lung Diseases
 Neural Tube Defects Antibodies  >1 publications with PRTN3 and Neural Tube Defects
Organs/Tissues associated with PRTN3 native protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with PRTN3 and Blood
 Bone Marrow Antibodies  >3 publications with PRTN3 and Bone Marrow
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