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SSB La native protein

Scan QR to view Datasheet Catalog #    MBS537359 SSB La native protein
Unit / Price
0.2 mg  /  $560 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SSB La, Native Protein

★Popular Item★
 Also Known As   

SSB La protein

 Product Synonym Names    SSB protein; Single stranded binding protein; Single stranded binding La protein
 Product Gene Name   

SSB La native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109090
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 Host    Bovine
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 Purity/Purification    > 90% pure
 Form/Format    20mM Hepes-NaOH, pH 7.4, with 0.32M NaCl, 0.2mM dithiothreitol, 0.1mM PMSF, 20% glycerol, and stabilizers.
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 Source Note    Calf Thymus
 Protein Type    Native
 Biological Significance    La antigen binds to the oligo(U) 3' termini of nascent RNA polymerase III transcripts and facilitates transcriptional termination and reinitiation by this enzyme13,-17. It has also been reported to function as an ATP-dependent helicase able to melt RNA-DNA hybrids.
 Dry Ice Shipment    Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of SSB La native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SSB La native protein

   Purified native Bovine SSB La protein
 Product Categories/Family for SSB La native protein    Cancer; Native Protein
 Applications Tested/Suitable for SSB La native protein   

ELISA (EIA)

 Application Notes for SSB La native protein    0.5-1 ug/ml
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NCBI/Uniprot data below describe general gene information for SSB La. It may not necessarily be applicable to this product.
 NCBI GI #    18089160
 NCBI GeneID    6741
 NCBI Accession #    AAH20818.1 [Other Products]
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 UniProt Secondary Accession #    Q15367; Q53XJ4 [Other Products]
 UniProt Related Accession #    P05455 [Other Products]
 Molecular Weight    48 kDa
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 NCBI Official Full Name    Sjogren syndrome antigen B (autoantigen La)
 NCBI Official Synonym Full Names    Sjogren syndrome antigen B (autoantigen La)
 NCBI Official Symbol    SSB [Similar Products]
 NCBI Official Synonym Symbols   
La; LARP3; La/SSB
[Similar Products]
 NCBI Protein Information    lupus La protein
 UniProt Protein Name    Lupus La protein
 UniProt Synonym Protein Names   
La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen; SS-B
 UniProt Gene Name    SSB [Similar Products]
 UniProt Synonym Gene Names    SS-B [Similar Products]
 UniProt Entry Name    LA_HUMAN
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 NCBI Summary for SSB La    The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
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 UniProt Comments for SSB La    SSB: a nuclear protein that plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5s, 7s, and 7-2 RNAs.

Protein type: Transcription initiation complex

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: nucleus; ribonucleoprotein complex

Molecular Function: mRNA binding; protein binding; nucleotide binding; tRNA binding

Biological Process: RNA processing; histone mRNA metabolic process; tRNA modification
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 Research Articles on SSB La    1. expression of nuclear hLa Ag induces thymic clonal deletion and tTreg selection, and lymphocytic infiltration of the lung is a consequence of La-specific CD4(+) T cell autoimmunity
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SSB La native proteinDiseases associated with SSB La native protein
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies  RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
 RNA Polymerase III Abortive And Retractive Initiation Pathway antibodies  RNA Polymerase III Abortive And Retractive Initiation Pathway Diagram
 RNA Polymerase III Transcription Pathway antibodies  RNA Polymerase III Transcription Pathway Diagram
 RNA Polymerase III Transcription Termination Pathway antibodies  RNA Polymerase III Transcription Termination Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >195 publications with SSB La and Heart Diseases
 Death Antibodies  >94 publications with SSB La and Death
 Vascular Diseases Antibodies  >94 publications with SSB La and Vascular Diseases
 Inflammation Antibodies  >74 publications with SSB La and Inflammation
 Kidney Diseases Antibodies  >52 publications with SSB La and Kidney Diseases
 Lung Diseases Antibodies  >51 publications with SSB La and Lung Diseases
 Weight Gain Antibodies  >40 publications with SSB La and Weight Gain
 Necrosis Antibodies  >40 publications with SSB La and Necrosis
 Fibrosis Antibodies  >39 publications with SSB La and Fibrosis
 Pain Antibodies  >35 publications with SSB La and Pain
Organs/Tissues associated with SSB La native protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >659 publications with SSB La and Blood
 Heart Antibodies  >255 publications with SSB La and Heart
 Skin Antibodies  >164 publications with SSB La and Skin
 Salivary Gland Antibodies  >157 publications with SSB La and Salivary Gland
 Liver Antibodies  >141 publications with SSB La and Liver
 Connective Tissue Antibodies  >129 publications with SSB La and Connective Tissue
 Mouth Antibodies  >121 publications with SSB La and Mouth
 Lung Antibodies  >97 publications with SSB La and Lung
 Muscle Antibodies  >84 publications with SSB La and Muscle
 Brain Antibodies  >74 publications with SSB La and Brain
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