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F2 native protein :: Thrombin Native Protein

Scan QR to view Datasheet Catalog #    MBS143463 F2 native protein
Unit / Price
500 Units  /  $360 +1 FREE 8GB USB
1000 Units  /  $550 +1 FREE 8GB USB
2000 Units  /  $745 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thrombin (F2), Native Protein

★Popular Item★
 Also Known As   

Porcine Thrombin

 Product Synonym Names    Thrombin Porcine; Porcine Thrombin; pThrombin
 Product Gene Name   

F2 native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Host    Porcine Blood
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 Form/Format    Lyophilized Powder from 20mM PBS, pH 7.4 containing 0.9% NaCl.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Thrombin in sterile 18M Omega -cm H2O.
 Biological Activity    One unit is defined as the amount of enzyme needed to cleave 1 mg of fusion protein in 16 hours to 95% completion at 20 degree C in a buffer containing 25mM Tris-HCl, pH 8.4, 150mM NaCl, and 2.5mM CaCl2.
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 Preparation and Storage    Lyophilized Thrombin although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IPF1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of F2 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for F2 native protein

   Introduction: Thrombin enzyme (Activated Factor IIa) is an important clotting promoter that controls the transformation of soluble fibrinogen to insoluble active fibrin strands. Thrombin is a coagulation protein and a serine protease (EC 3.4.21.5) that catalyzes many coagulation-related reactions. Thrombin triggers factor-XI, factor-V, Factor-XIII and factor-VIII. Thrombin endorses platelet activation, using activation of protease-activated receptors on the platelet. As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity.
 Product Categories/Family for F2 native protein    RECOMBINANT & NATURAL PROTEINS; Natural Proteins; Thrombin
NCBI/Uniprot data below describe general gene information for F2. It may not necessarily be applicable to this product.
 NCBI GI #    27806947
 NCBI GeneID    280685
 NCBI Accession #    NP_776302.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_173877.1 [Other Products]
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 UniProt Secondary Accession #    Q3MHK7 [Other Products]
 UniProt Related Accession #    P00735 [Other Products]
 Molecular Weight    70,506 Da [Similar Products]
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 NCBI Official Full Name    prothrombin
 NCBI Official Synonym Full Names    coagulation factor II (thrombin)<
 NCBI Official Symbol    F2 [Similar Products]
 NCBI Protein Information    prothrombin
 UniProt Protein Name    Prothrombin
 UniProt Synonym Protein Names   
Coagulation factor IICleaved into the following 4 chains:Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain
 Protein Family    Thrombin
 UniProt Gene Name    F2 [Similar Products]
 UniProt Entry Name    THRB_BOVIN
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 UniProt Comments for F2    Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing ().
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 Research Articles on F2    1. the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with F2 native proteinPathways associated with F2 native protein
 Reference Product  PubMed Publications
 SERPINC1 native protein  >22 publications with F2 and SERPINC1
 VWF native protein  >10 publications with F2 and VWF
 FGA native protein  >9 publications with F2 and FGA
 FGG native protein  >9 publications with F2 and FGG
 FGB native protein  >8 publications with F2 and FGB
 F2R native protein  >6 publications with F2 and F2R
 IGFBP3 native protein  >5 publications with F2 and IGFBP3
 THBD native protein  >2 publications with F2 and THBD
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
Diseases associated with F2 native proteinOrgans/Tissues associated with F2 native protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1119 publications with F2 and Nervous System Diseases
 Liver Diseases Antibodies  >854 publications with F2 and Liver Diseases
 Fibrosis Antibodies  >783 publications with F2 and Fibrosis
 Hypertension Antibodies  >694 publications with F2 and Hypertension
 Inflammation Antibodies  >613 publications with F2 and Inflammation
 Liver Cirrhosis Antibodies  >590 publications with F2 and Liver Cirrhosis
 Brain Diseases Antibodies  >496 publications with F2 and Brain Diseases
 Heart Diseases Antibodies  >317 publications with F2 and Heart Diseases
 Kidney Diseases Antibodies  >276 publications with F2 and Kidney Diseases
 Obesity Antibodies  >267 publications with F2 and Obesity
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2017 publications with F2 and Muscle
 Liver Antibodies  >1508 publications with F2 and Liver
 Embryonic Tissue Antibodies  >375 publications with F2 and Embryonic Tissue
 Testis Antibodies  >164 publications with F2 and Testis
 Reticulum Antibodies  >79 publications with F2 and Reticulum
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