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TMSB4X native protein :: Thymosin-b4 Native Protein

Scan QR to view Datasheet Catalog #    MBS142668 TMSB4X native protein
Unit / Price
1 mg  /  $205 +1 FREE 8GB USB
5 mg  /  $595 +1 FREE 8GB USB
25 mg  /  $1,900 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thymosin-b4 (TMSB4X), Native Protein

★Popular Item★
 Also Known As   

Thymosin-b4

 Product Synonym Names    Thymosin beta4; Thymosin beta4; Thymosin b4; Thymosin beta-4; T beta 4; Fx; TB4X; PTMB4; TMSB4; Thymosin beta4
 Product Gene Name   

TMSB4X native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Thymosin b4 has an a.a. sequence of Ac-Ser-Asp -Lys-Pro-A sp-Met-Ala -Glu-Ile-G lu-Lys-Phe -Asp-Lys-S er-Lys-Leu -Lys-Lys-T hr-Glu-Thr -Gln-Glu-L ys-Asn-Pro -Leu-Pro-S er-Lys-Glu -Thr-Ile-G lu-Gln-Glu -Lys-Gln-A la-Gly-Glu -Ser-OH
 OMIM    300159
 3D Structure    ModBase 3D Structure for P62328
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 Purity/Purification    Greater than 98.0% as determined by RP-HPLC.
 Form/Format    The protein (1 mg/ml) was lyophilized with no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Thymosin beta-4 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
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 Preparation and Storage    Lyophilized Thymosin b4 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution T beta 4 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of TMSB4X native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TMSB4X native protein

   Description: Thymosin b4 is a 43 amino acid peptide which is regarded as the main intracellular G-actin sequestering peptide.It has a molecular weight of 4963.55 Da, and its molecular formula is: C212H350N56O78S1. Extracellular Thymosin b4 may contribute to physiological processes such as angiogenesis, wound healing, and regulation of inflammation. Thymosin b4 has an a.a. sequence of Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH.

Introduction: Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to produce antibodies. The predominant form of thymosin, thymosin b4, is a member of a highly conserved family of actin monomer-sequestering proteins. b-thymosins are the primary regulators of unpolymerized actin, and are essential for maintaining the small cytoplasmic pool of free G-actin monomers required for rapid filament elongation and allowing for the flux of monomers between the thymosin-bound pool and F-actin.
 Product Categories/Family for TMSB4X native protein    HORMONES; Hormones; Thymosin
NCBI/Uniprot data below describe general gene information for TMSB4X. It may not necessarily be applicable to this product.
 NCBI GI #    11056061
 NCBI GeneID    7114
 NCBI Accession #    NP_066932.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021109.3 [Other Products]
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 UniProt Primary Accession #    P62328 [Other Products]
 UniProt Secondary Accession #    P01253; P01254; Q546P5; Q63576; Q9UE55 [Other Products]
 UniProt Related Accession #    P62328 [Other Products]
 Molecular Weight    5,053 Da [Similar Products]
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 NCBI Official Full Name    thymosin beta-4
 NCBI Official Synonym Full Names    thymosin beta 4, X-linked
 NCBI Official Symbol    TMSB4X [Similar Products]
 NCBI Official Synonym Symbols   
FX; TB4X; PTMB4; TMSB4
[Similar Products]
 NCBI Protein Information    thymosin beta-4; prothymosin beta-4; t beta-4; thymosin, beta 4, X chromosome
 UniProt Protein Name    Thymosin beta-4
 UniProt Synonym Protein Names   
FxHematopoietic system regulatory peptideAlternative name(s):Seraspenide
 Protein Family    Thymosin
 UniProt Gene Name    TMSB4X [Similar Products]
 UniProt Synonym Gene Names    TB4X; THYB4; TMSB4; T beta-4 [Similar Products]
 UniProt Entry Name    TYB4_HUMAN
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 NCBI Summary for TMSB4X    This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TMSB4X    TMSB4X: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xq21.3-q22

Cellular Component: cytoskeleton; extracellular region

Molecular Function: actin monomer binding; protein binding

Biological Process: platelet activation; platelet degranulation; sequestering of actin monomers; actin filament organization; blood coagulation
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 Research Articles on TMSB4X    1. Thymosin beta4 induces invasion and migration of human colorectal cancer cells through the ILK/AKT/beta-catenin signaling pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TMSB4X native proteinDiseases associated with TMSB4X native protein
 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >3 publications with TMSB4X and Disease Models, Animal
 Carcinoma Antibodies  >2 publications with TMSB4X and Carcinoma
 Neoplasms, Experimental Antibodies  >2 publications with TMSB4X and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >1 publications with TMSB4X and Adenocarcinoma
 Liver Diseases Antibodies  >1 publications with TMSB4X and Liver Diseases
 Liver Neoplasms, Experimental Antibodies  >1 publications with TMSB4X and Liver Neoplasms, Experimental
 Liver Neoplasms Antibodies  >1 publications with TMSB4X and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with TMSB4X and Carcinoma, Hepatocellular
 Inflammation Antibodies  >1 publications with TMSB4X and Inflammation
Organs/Tissues associated with TMSB4X native protein
 Organ/Tissue Name  Pubmed Publications
 Mouth Antibodies  >1 publications with TMSB4X and Mouth
 Muscle Antibodies  >1 publications with TMSB4X and Muscle
 Bone Antibodies  >1 publications with TMSB4X and Bone
 Testis Antibodies  >1 publications with TMSB4X and Testis
 Embryonic Tissue Antibodies  >1 publications with TMSB4X and Embryonic Tissue
 Heart Antibodies  >1 publications with TMSB4X and Heart
 Blood Antibodies  >1 publications with TMSB4X and Blood
 Liver Antibodies  >1 publications with TMSB4X and Liver
 Vascular Antibodies  >1 publications with TMSB4X and Vascular
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