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TG native protein :: Thyroglobulin Native Protein

Scan QR to view Datasheet Catalog #    MBS537264 TG native protein
Unit / Price
1 mg  /  $180 +1 FREE 8GB USB
10 mg  /  $755 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thyroglobulin (TG), Native Protein

★Popular Item★
 Also Known As   

Thyroglobulin protein

 Product Synonym Names    hTg protein; Tg protein
 Product Gene Name   

TG native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    188450
 3D Structure    ModBase 3D Structure for P01266
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 Host    Human
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 Purity/Purification    > 98% pure by SDS-PAGE
 Form/Format    White/off-white powder, lyophilized from 0.02M NH4HCO3. Reconstitute with a Phosphate Buffer solution, pH > 7.0 containing 0.15M NaCl
 Concentration    1.0mg, Lyophilized (lot specific)
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 Source    Human thyroid tissue
 Protein Type    Native
 Biological Significance    Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. In earlier literature, Tg was referred to as colloid. Thyroglobulin should not be confused with Thyroxine-binding globulin, a carrier protein responsible for carrying the thyroid hormones in the blood.
 Grade    Highly Pure
 Biohazard    Pooled raw material tested negative for anti-HCV, anti-HIV I and II, HBsAg and Syphilis by FDA approved methods.
    
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 Preparation and Storage    4 degree C lyophilized, after reconstitution aliquot and store at -20 degree C or below.
 Other Notes    Small volumes of TG native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TG native protein

   Purified native Human Thyroglobulin protein
 Product Categories/Family for TG native protein    Hormones & Steroids; Native Protein
 Applications Tested/Suitable for TG native protein   

User optimized

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NCBI/Uniprot data below describe general gene information for TG. It may not necessarily be applicable to this product.
 NCBI GI #    37174
 NCBI GeneID    7038
 NCBI Accession #    CAA29104.1 [Other Products]
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 UniProt Primary Accession #    P01266 [Other Products]
 UniProt Secondary Accession #    O15274; O43899; Q15593; Q15948; Q9NYR1; Q9NYR2; Q9UMZ0; Q9UNY3 [Other Products]
 UniProt Related Accession #    P01266 [Other Products]
 Molecular Weight    660 kDa [Similar Products]
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 NCBI Official Full Name    thyroglobulin
 NCBI Official Synonym Full Names    thyroglobulin
 NCBI Official Symbol    TG [Similar Products]
 NCBI Official Synonym Symbols   
TGN; AITD3
[Similar Products]
 NCBI Protein Information    thyroglobulin
 UniProt Protein Name    Thyroglobulin
 Protein Family    Thyroglobulin
 UniProt Gene Name    TG [Similar Products]
 UniProt Synonym Gene Names    Tg [Similar Products]
 UniProt Entry Name    THYG_HUMAN
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 NCBI Summary for TG    Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
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 UniProt Comments for TG    TG: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity

Biological Process: regulation of myelination; iodide transport; thyroid gland development; hormone biosynthetic process; signal transduction; thyroid hormone metabolic process

Disease: Thyroid Dyshormonogenesis 3; Autoimmune Thyroid Disease, Susceptibility To, 3
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 Research Articles on TG    1. Data suggest serum TG level (low but measurable following stimulation with recombinant thyroid stimulating hormone or withdrawal of thyroid hormone) is predictive of incomplete response to surgery/radioiodine therapy in differentiated thyroid cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TG native proteinDiseases associated with TG native protein
 Products by Pathway  Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Thyroid Hormone Synthesis Pathway antibodies  Thyroid Hormone Synthesis Pathway Diagram
 Thyroid Hormone Synthesis Pathway antibodies  Thyroid Hormone Synthesis Pathway Diagram
 Thyroxine (Thyroid Hormone) Production Pathway antibodies  Thyroxine (Thyroid Hormone) Production Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >4895 publications with TG and Cardiovascular Diseases
 Thyroid Diseases Antibodies  >2458 publications with TG and Thyroid Diseases
 Fatty Liver Antibodies  >1755 publications with TG and Fatty Liver
 Inflammation Antibodies  >1573 publications with TG and Inflammation
 Liver Diseases Antibodies  >1537 publications with TG and Liver Diseases
 Hypertension Antibodies  >1429 publications with TG and Hypertension
 Thyroid Neoplasms Antibodies  >1234 publications with TG and Thyroid Neoplasms
 Necrosis Antibodies  >901 publications with TG and Necrosis
 Kidney Diseases Antibodies  >834 publications with TG and Kidney Diseases
 Goiter Antibodies  >651 publications with TG and Goiter
Organs/Tissues associated with TG native protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16742 publications with TG and Blood
 Liver Antibodies  >4122 publications with TG and Liver
 Thyroid Antibodies  >3193 publications with TG and Thyroid
 Muscle Antibodies  >2403 publications with TG and Muscle
 Brain Antibodies  >2309 publications with TG and Brain
 Kidney Antibodies  >1321 publications with TG and Kidney
 Connective Tissue Antibodies  >1098 publications with TG and Connective Tissue
 Lymph Node Antibodies  >704 publications with TG and Lymph Node
 Intestine Antibodies  >616 publications with TG and Intestine
 Pancreas Antibodies  >460 publications with TG and Pancreas
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