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TF native protein :: Transferrin Native Protein

Scan QR to view Datasheet Catalog #    MBS537254 TF native protein
Unit / Price
1 mg  /  $285 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transferrin (TF), Native Protein

★Popular Item★
 Also Known As   

Transferrin protein (HRP)

 Product Synonym Names    TF protein; beta 1 metal binding globulin protein; Siderophilin protein; Apotransferrin protein; Serotransferrin precursor protein; DKFZp781D0156 protein; PRO2086 protein; PRO1400 protein; PRO1557 protein
 Product Gene Name   

TF native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    190000
 3D Structure    ModBase 3D Structure for P02787
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 Purity/Purification    Transferrin protein (HRP) was purified by selective precipitation and tandem chromatography followed by dialysis.
 Form/Format    Supplied lyophilzed in 20mM Potassium Phosphate, 150mM Sodium Azide Chloride, pH 7.2, 10mg/ml BSA, with 0.01% Gentamicin Sulfate as preservative. Reconstitute with 1.0ml of deionized water. Do Not Add Sodium Azide!
 Concentration    1.0 mg, lyophilized (lot specific)
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 Source    Human serum
 Protein Type    Native
 Note    A single precipitin arc was observed against anti-Peroxidase, anti-Human Transferrin and anti-Human serum, when assayed by Immunoelectrophoresis.
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 Preparation and Storage    Ships ambient or refridgerated. Upon receipt store at 4 degree C prior to reconstitution. For longer storage, aliquot and store at -20 degree C. Stable for serveral weeks at 4 degree C as an undiluted liquid.
 Other Notes    Small volumes of TF native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TF native protein

   Transferrins are iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. In humans, it is encoded by the TF gene. Transferrin is a glycoprotein that binds iron very tightly but reversibly. Although iron bound to transferrin is less than 0.1% (4 mg) of the total body iron, it is the most important iron pool, with the highest rate of turnover (25 mg/24 h). Transferrin has a molecular weight of around 80 kDa and contains 2 specific high-affinity Fe(III) binding sites.
 Product Categories/Family for TF native protein    Nutrition & Metabolism; Native Protein; Conjugated Proteins
 Applications Tested/Suitable for TF native protein   

User optimized

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NCBI/Uniprot data below describe general gene information for TF. It may not necessarily be applicable to this product.
 NCBI GI #    248648
 NCBI GeneID    7018
 NCBI Accession #    AAB22049.1 [Other Products]
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 UniProt Primary Accession #    P02787 [Other Products]
 UniProt Secondary Accession #    O43890; Q1HBA5; Q9NQB8; Q9UHV0 [Other Products]
 UniProt Related Accession #    P02787 [Other Products]
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 NCBI Official Full Name    transferrin
 NCBI Official Synonym Full Names    transferrin
 NCBI Official Symbol    TF [Similar Products]
 NCBI Official Synonym Symbols   
TFQTL1; PRO1557; PRO2086
[Similar Products]
 NCBI Protein Information    serotransferrin
 UniProt Protein Name    Serotransferrin
 UniProt Synonym Protein Names   
Beta-1 metal-binding globulin; Siderophilin
 Protein Family    Transferrin
 UniProt Gene Name    TF [Similar Products]
 UniProt Synonym Gene Names    Transferrin [Similar Products]
 UniProt Entry Name    TRFE_HUMAN
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 NCBI Summary for TF    This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]
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 UniProt Comments for TF    TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: extracellular space; cell surface; cytoplasmic membrane-bound vesicle; early endosome; extracellular region; coated pit; recycling endosome; perinuclear region of cytoplasm; endocytic vesicle; late endosome; apical plasma membrane; basal plasma membrane; endosome membrane; vesicle

Molecular Function: protein binding; ferric iron binding; ubiquitin protein ligase binding

Biological Process: retinal homeostasis; platelet activation; platelet degranulation; cellular iron ion homeostasis; transferrin transport; blood coagulation; transmembrane transport

Disease: Atransferrinemia
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 Research Articles on TF    1. genetic association studies in a population of black women in South Africa: Data confirm that an SNP in TF (rs1799852) is associated with iron status/iron-deficiency anemia in the population studied.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TF native proteinPathways associated with TF native protein
 Reference Product  PubMed Publications
 ALB native protein  >88 publications with TF and ALB
 TFR2 native protein  >44 publications with TF and TFR2
 TFRC native protein  >22 publications with TF and TFRC
 HIF1A native protein  >19 publications with TF and HIF1A
 SLC40A1 native protein  >7 publications with TF and SLC40A1
 IGFBP3 native protein  >6 publications with TF and IGFBP3
 APOA1 native protein  >5 publications with TF and APOA1
 HEPH native protein  >5 publications with TF and HEPH
 Products by Pathway  Pathway Diagram
 EPHB Forward Signaling Pathway antibodies  EPHB Forward Signaling Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Iron Metabolism In Placenta Pathway antibodies  Iron Metabolism In Placenta Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
Diseases associated with TF native proteinOrgans/Tissues associated with TF native protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1526 publications with TF and Cardiovascular Diseases
 Inflammation Antibodies  >841 publications with TF and Inflammation
 Nervous System Diseases Antibodies  >707 publications with TF and Nervous System Diseases
 Carcinoma Antibodies  >549 publications with TF and Carcinoma
 Necrosis Antibodies  >523 publications with TF and Necrosis
 Immune System Diseases Antibodies  >443 publications with TF and Immune System Diseases
 Atherosclerosis Antibodies  >298 publications with TF and Atherosclerosis
 Liver Diseases Antibodies  >260 publications with TF and Liver Diseases
 Lung Neoplasms Antibodies  >186 publications with TF and Lung Neoplasms
 Liver Neoplasms Antibodies  >147 publications with TF and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4779 publications with TF and Blood
 Brain Antibodies  >987 publications with TF and Brain
 Heart Antibodies  >740 publications with TF and Heart
 Liver Antibodies  >652 publications with TF and Liver
 Muscle Antibodies  >572 publications with TF and Muscle
 Lung Antibodies  >500 publications with TF and Lung
 Kidney Antibodies  >457 publications with TF and Kidney
 Embryonic Tissue Antibodies  >387 publications with TF and Embryonic Tissue
 Nerve Antibodies  >225 publications with TF and Nerve
 Skin Antibodies  >219 publications with TF and Skin
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