NP_003271.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
troponin C, slow skeletal and cardiac muscles
NCBI Official Synonym Full Names
troponin C type 1 (slow)
NCBI Protein Information
troponin C, slow skeletal and cardiac muscles
UniProt Protein Name
Troponin C, slow skeletal and cardiac muscles
UniProt Synonym Gene Names
UniProt Entry Name
TNNC1_HUMAN
NCBI Summary for TNNC1
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]
UniProt Comments for TNNC1
TNNC1: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13). A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Belongs to the troponin C family.
Protein type: Motility/polarity/chemotaxis; Calcium-binding
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component: nucleoplasm; troponin complex; mitochondrion; cytosol; actin cytoskeleton
Molecular Function: actin filament binding; troponin T binding; protein binding; protein homodimerization activity; troponin I binding; calcium ion binding; calcium-dependent protein binding
Biological Process: regulation of ATPase activity; response to metal ion; regulation of muscle contraction; diaphragm contraction; ventricular cardiac muscle morphogenesis; regulation of muscle filament sliding speed; cardiac muscle contraction; muscle filament sliding
Disease: Cardiomyopathy, Dilated, 1z; Cardiomyopathy, Familial Hypertrophic, 13
Research Articles on TNNC1
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Products associated with TNNC1 native protein
Pathways associated with TNNC1 native protein
Diseases associated with TNNC1 native protein
Disease Name |
Pubmed Publications |
Heart Diseases Antibodies |
>22 publications with TNNC1 and Heart Diseases |
Cardiomyopathy, Familial Hypertrophic, 1 Antibodies |
>3 publications with TNNC1 and Cardiomyopathy, Familial Hypertrophic, 1 |
Hypertrophy Antibodies |
>2 publications with TNNC1 and Hypertrophy |
Fetal Death Antibodies |
>1 publications with TNNC1 and Fetal Death |
Hypertension Antibodies |
>1 publications with TNNC1 and Hypertension |
Neoplasms, Experimental Antibodies |
>1 publications with TNNC1 and Neoplasms, Experimental |
Disease Models, Animal Antibodies |
>1 publications with TNNC1 and Disease Models, Animal |
Kidney Diseases Antibodies |
>1 publications with TNNC1 and Kidney Diseases |
Cardiomyopathy, Familial Hypertrophic, 13 Antibodies |
>1 publications with TNNC1 and Cardiomyopathy, Familial Hypertrophic, 13 |
Organs/Tissues associated with TNNC1 native protein
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