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Tnnt2 native protein :: Troponin T Native Protein

Scan QR to view Datasheet Catalog #    MBS537207 Tnnt2 native protein
Unit / Price
0.1 mg  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Troponin T (Tnnt2), Native Protein

 Also Known As   

Troponin T protein (Cardiac)

 Product Synonym Names    TnT protein
 Product Gene Name   

Tnnt2 native protein

[Similar Products]
 Matching Pairs    Antibody: Troponin T Clone #M401134 (MBS530117)
Antigen: Troponin T (MBS537207)
Comments: >98% pure by SDS-PAGE
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P50753
 Host    Human
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 Purity/Purification    > 98% pure
 Form/Format    50mM TRIS.HCl, pH 7.2, with 250mM NaCl, 6M Urea, 15mM beta-mercaptoethanol, and 1mM EDTA.
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 Source Note    Human cardiac tissue
 Protein Type    Native
 Biological Significance    Troponin T is a part of the troponin complex. It binds to tropomyosin, interlocking them to form a troponin-tropomyosin complex. Troponin T binds to tropomyosin and helps position it on actin. And in a less complicated light, Troponin T modulates contraction of striated muscle.
 Biohazard Information    Donor samples were tested and found to be negative for HBsAg, Anti-HIV-1/HIV-2, & HCV. Nonetheless caution should be used when handling this material as there is a margin of error in all tests. This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Dry Ice Shipment    Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
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 Preparation and Storage    Aliquot and store at -20 degree C for short term storage, -70 degree C for long-term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of Tnnt2 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Tnnt2 native protein

   Purified native Human Troponin T protein (Cardiac)
 Product Categories/Family for Tnnt2 native protein    Cardiac Markers; Native Protein
 Applications Tested/Suitable for Tnnt2 native protein   

User optimized

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NCBI/Uniprot data below describe general gene information for Tnnt2. It may not necessarily be applicable to this product.
 NCBI GI #    207522
 NCBI GeneID    24837
 NCBI Accession #    AAA42297.1 [Other Products]
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 UniProt Primary Accession #    P50753 [Other Products]
 UniProt Related Accession #    P50753 [Other Products]
 Molecular Weight    34,452 Da [Similar Products]
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 NCBI Official Full Name    troponin T
 NCBI Official Synonym Full Names    troponin T type 2 (cardiac)
 NCBI Official Symbol    Tnnt2 [Similar Products]
 NCBI Official Synonym Symbols   
Ctt; CTTG; Tnnt3; RATCTTG
[Similar Products]
 NCBI Protein Information    troponin T, cardiac muscle
 UniProt Protein Name    Troponin T, cardiac muscle
 UniProt Synonym Protein Names   
Cardiac muscle troponin T; cTnT
 Protein Family    Troponin
 UniProt Gene Name    Tnnt2 [Similar Products]
 UniProt Synonym Gene Names    TnTc; cTnT [Similar Products]
 UniProt Entry Name    TNNT2_RAT
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 NCBI Summary for Tnnt2    tropomyosin-binding subunit of troponin; confers calcium-sensitivy to actinomysin ATPase activity in striated muscle [RGD, Feb 2006]
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 UniProt Comments for Tnnt2    TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Motor

Cellular Component: sarcomere; troponin complex; myofibril; cytoplasm; striated muscle thin filament

Molecular Function: protein binding, bridging; troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; tropomyosin binding; actin binding

Biological Process: actin crosslink formation; atrial cardiac muscle morphogenesis; metabolic process; protein heterooligomerization; regulation of muscle contraction; heart development; regulation of muscle filament sliding speed; sarcomere organization; regulation of heart contraction; muscle filament sliding; muscle contraction; positive regulation of ATPase activity; ventricular cardiac muscle morphogenesis; response to calcium ion; negative regulation of ATPase activity; cardiac muscle contraction
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 Research Articles on Tnnt2    1. Replacement of the functionally corresponding N-terminal end portion of rat fast skeletal cardiac muscle (RfsTnT) into cardiac muscle troponin T (RcTnT), the observed functional differences associate with a sequence variation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Tnnt2 native proteinPathways associated with Tnnt2 native protein
 Reference Product  PubMed Publications
 Tnni3 native protein  >59 publications with Tnnt2 and Tnni3
 Tpm1 native protein  >39 publications with Tnnt2 and Tpm1
 Tpm3 native protein  >25 publications with Tnnt2 and Tpm3
 Tnnc1 native protein  >14 publications with Tnnt2 and Tnnc1
 Tnnt1 native protein  >2 publications with Tnnt2 and Tnnt1
 Acta2 native protein  >1 publications with Tnnt2 and Acta2
 Tpm4 native protein  >1 publications with Tnnt2 and Tpm4
 Tpm2 native protein  >1 publications with Tnnt2 and Tpm2
 Tnni2 native protein  >1 publications with Tnnt2 and Tnni2
 Tnni1 native protein  >1 publications with Tnnt2 and Tnni1
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
Diseases associated with Tnnt2 native proteinOrgans/Tissues associated with Tnnt2 native protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >174 publications with Tnnt2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >169 publications with Tnnt2 and Heart Diseases
 Cardiomyopathies Antibodies  >131 publications with Tnnt2 and Cardiomyopathies
 Cardiomyopathy, Hypertrophic Antibodies  >106 publications with Tnnt2 and Cardiomyopathy, Hypertrophic
 Cardiomyopathy, Hypertrophic, Familial Antibodies  >49 publications with Tnnt2 and Cardiomyopathy, Hypertrophic, Familial
 Cardiomyopathy, Dilated Antibodies  >47 publications with Tnnt2 and Cardiomyopathy, Dilated
 Cardiomegaly Antibodies  >47 publications with Tnnt2 and Cardiomegaly
 Hypertrophy Antibodies  >41 publications with Tnnt2 and Hypertrophy
 Heart Failure Antibodies  >40 publications with Tnnt2 and Heart Failure
 Death, Sudden, Cardiac Antibodies  >37 publications with Tnnt2 and Death, Sudden, Cardiac
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >132 publications with Tnnt2 and Heart
 Embryonic Tissue Antibodies  >18 publications with Tnnt2 and Embryonic Tissue
 Lung Antibodies  >5 publications with Tnnt2 and Lung
 Connective Tissue Antibodies  >3 publications with Tnnt2 and Connective Tissue
 Prostate Antibodies  >2 publications with Tnnt2 and Prostate
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