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VWF native protein

Scan QR to view Datasheet Catalog #    MBS537347 VWF native protein
Unit / Price
0.1 mg  /  $795 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VWF, Native Protein

 Also Known As   

VWF protein (Factor VIII Free)

 Product Synonym Names    Von Willebrand Factor VIII Free Protein
 Product Gene Name   

VWF native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q8CIZ8
 Host    Human
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 Purity/Purification    > 95% pure
 Form/Format    25mM sodium citrate, 100mM NaCl, 100mM Glycine, pH 6.8.
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 Source Note    Human serum/plasma
 Protein Type    Native
 Biological Significance    Von Willebrand factor (vWF) is a multimeric plasma glycoprotein that is required for normal hemostatic platelet plug formation. The mature plasma protein is composed of apparently identical subunits (Mr=260,000) which are held together by disulfide bonds. The circulating vWF molecule ranges in size from dimers (Mr=520,000) to extremely large multimers (Mr>10,000,000). During normal hemostasis, the larger multimers of vWF are responsible for facilitating platelet plug formation by forming a bridge between platelet glycoprotein IB and exposed collagen in the subendothelium.
 Biohazard Information    Donor samples were tested and found to be negative for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
 Dry Ice Shipment    Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
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 Preparation and Storage    Aliquot and store at -80 degree C or lower. Avoid repeated freeze/thaw cycles
 Other Notes    Small volumes of VWF native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for VWF native protein

   Purified native Human VWF protein (Factor VIII Free)
 Product Categories/Family for VWF native protein    Cancer; Native Protein
 Applications Tested/Suitable for VWF native protein   

User optimized

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NCBI/Uniprot data below describe general gene information for VWF. It may not necessarily be applicable to this product.
 NCBI GI #    86129842
 NCBI GeneID    22371
 NCBI Accession #    ABC86573.1 [Other Products]
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 UniProt Primary Accession #    Q8CIZ8 [Other Products]
 UniProt Secondary Accession #    Q60863; Q6XUV6; Q8BIU9; Q8CGN0; Q9JK16 [Other Products]
 UniProt Related Accession #    Q8CIZ8 [Other Products]
 Molecular Weight    260 kDa
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 NCBI Official Full Name    VWF
 NCBI Official Synonym Full Names    Von Willebrand factor homolog
 NCBI Official Symbol    Vwf [Similar Products]
 NCBI Official Synonym Symbols   
VWD; F8VWF; AI551257; C630030D09; 6820430P06Rik; B130011O06Rik
[Similar Products]
 NCBI Protein Information    von Willebrand factor
 UniProt Protein Name    von Willebrand factor
 UniProt Synonym Protein Names   
von Willebrand antigen 2Alternative name(s):von Willebrand antigen II
 Protein Family    von Willebrand factor
 UniProt Gene Name    Vwf [Similar Products]
 UniProt Synonym Gene Names    vWF [Similar Products]
 UniProt Entry Name    VWF_MOUSE
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 UniProt Comments for VWF    VWF: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Defects in VWF are the cause of von Willebrand disease type 1 (VWD1). A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 2 (VWD2). A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in their platelet- dependent function, whereas the mutant protein in type 2N is defective in its ability to bind factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 3 (VWD3). A severe hemorrhagic disorder due to a total or near total absence of von Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII. Bleeding usually starts in infancy and can include epistaxis, recurrent mucocutaneous bleeding, excessive bleeding after minor trauma, and hemarthroses.

Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Cell adhesion

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; endoplasmic reticulum; extracellular region; external side of plasma membrane

Molecular Function: collagen binding; integrin binding; identical protein binding; protein binding; protein homodimerization activity; protease binding; chaperone binding; protein N-terminus binding; immunoglobulin binding; glycoprotein binding

Biological Process: platelet activation; hemostasis; cell adhesion; blood coagulation; liver development; protein homooligomerization; cell-substrate adhesion; placenta development
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 Research Articles on VWF    1. We conclude that TSP1 released from platelets plays a mechanistic role in modulating thrombosis in the presence of von Willebrand factor
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with VWF native proteinPathways associated with VWF native protein
 Reference Product  PubMed Publications
 Serpine1 native protein  >309 publications with VWF and Serpine1
 Vegfa native protein  >50 publications with VWF and Vegfa
 Gp1ba native protein  >19 publications with VWF and Gp1ba
 Itgb3 native protein  >10 publications with VWF and Itgb3
 Itga2b native protein  >7 publications with VWF and Itga2b
 Gp9 native protein  >2 publications with VWF and Gp9
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
Diseases associated with VWF native proteinOrgans/Tissues associated with VWF native protein
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >2052 publications with VWF and Vascular Diseases
 Cardiovascular Diseases Antibodies  >2031 publications with VWF and Cardiovascular Diseases
 Thrombosis Antibodies  >1466 publications with VWF and Thrombosis
 Heart Diseases Antibodies  >632 publications with VWF and Heart Diseases
 Inflammation Antibodies  >622 publications with VWF and Inflammation
 Atherosclerosis Antibodies  >377 publications with VWF and Atherosclerosis
 Kidney Diseases Antibodies  >328 publications with VWF and Kidney Diseases
 Hypertension Antibodies  >305 publications with VWF and Hypertension
 Disease Models, Animal Antibodies  >294 publications with VWF and Disease Models, Animal
 Necrosis Antibodies  >261 publications with VWF and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >279 publications with VWF and Brain
 Embryonic Tissue Antibodies  >278 publications with VWF and Embryonic Tissue
 Bone Marrow Antibodies  >254 publications with VWF and Bone Marrow
 Lung Antibodies  >250 publications with VWF and Lung
 Skin Antibodies  >245 publications with VWF and Skin
 Connective Tissue Antibodies  >134 publications with VWF and Connective Tissue
 Joint Antibodies  >75 publications with VWF and Joint
 Eye Antibodies  >60 publications with VWF and Eye
 Spleen Antibodies  >46 publications with VWF and Spleen
 Inner Ear Antibodies  >10 publications with VWF and Inner Ear
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