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GC native protein :: Vitamin D Binding Protein (Gc-Globulin) Native Protein

Scan QR to view Datasheet Catalog #    MBS318215 GC native protein
Unit / Price
1 mg  /  $250 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Vitamin D Binding Protein (Gc-Globulin), Native Protein

★Popular Item★
 Also Known As   

Vitamin D Bind.Prot (GC-Glob.)

 Product Synonym Names    Purified Vitamin D Binding Protein (GC Globulin)
 Product Gene Name   

GC native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (72607410..72649888, complement). Location: 4q12-q13
 OMIM    139200
 3D Structure    ModBase 3D Structure for P02774
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 Specificity    Vitamin D Binding Protein (Gc-Globulin)
 Purity/Purification    >95% pure (SDS-PAGE)
 Form/Format    Purified, Lyophilized.
Reconstitute with distilled water.
 Concentration    3.76 mg/ml (prior to lyophilization) (lot specific)
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 Source    Human Plasma
 Buffer    Lyophilized from 20mM Sodium Phosphate, pH 7.4 containing 150mM Sodium chloride
 Preservative    None
 Safety Notes    Refer to the apporpiate Safety Data Sheet (SDS) for additional information.
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 Preparation and Storage    Store lyophilized product at -20C to -70C. After reconstitution, aliquot and store at -20C to -70C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of GC native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GC native protein

   Vitamin D Bind.Prot (GC-Glob.)

Purified Vitamin D Binding Protein (GC Globulin).
 Product Categories/Family for GC native protein    Purified Proteins and Bioactive Peptides
 Application Notes for GC native protein    Specific methodologies have not been tested using this product.
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NCBI/Uniprot data below describe general gene information for GC. It may not necessarily be applicable to this product.
 NCBI GI #    32483410
 NCBI GeneID    2638
 NCBI Accession #    NP_000574.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000583.3 [Other Products]
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 UniProt Primary Accession #    P02774 [Other Products]
 UniProt Secondary Accession #    Q16309; Q16310; Q53F31; Q6GTG1; B4DPP2 [Other Products]
 UniProt Related Accession #    P02774; Q6LDC6 [Other Products]
 Molecular Weight    Molecular Weight||52 kDa (SDS-PAGE, reducing conditions) [Similar Products]
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 NCBI Official Full Name    vitamin D-binding protein isoform 1
 NCBI Official Synonym Full Names    group-specific component (vitamin D binding protein)
 NCBI Official Symbol    GC [Similar Products]
 NCBI Official Synonym Symbols   
DBP; GRD3; VDBG; VDBP; DBP/GC
[Similar Products]
 NCBI Protein Information    vitamin D-binding protein; VDB; gc-globulin; OTTHUMP00000160364; OTTHUMP00000218973; OTTHUMP00000218974; OTTHUMP00000218975; vitamin D-binding alpha-globulin
 UniProt Protein Name    Vitamin D-binding protein
 UniProt Synonym Protein Names   
Gc-globulin; Group-specific component
 Protein Family    Vitamin D-binding protein
 UniProt Gene Name    GC [Similar Products]
 UniProt Entry Name    VTDB_HUMAN
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 NCBI Summary for GC    The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq]
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 UniProt Comments for GC    Function: Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.

Subcellular location: Secreted.

Polymorphism: Over 80 variants of human DBP have been identified. The three most common alleles are called GC*1F, GC*1S, and GC*2. The sequence shown is that of the GC*2 allele.

Sequence similarities: Belongs to the ALB/AFP/VDB family.Contains 3 albumin domains.

Sequence caution: The sequence BAG60654.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.
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 Research Articles on GC    1. This study has replicated associations to chronic obstructive pulmonary disease phenotypes in the STAT1, NFKBIB/SIRT2 and GC genes in two independent populations, the associations of the former two genes representing novel findings.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with GC native proteinDiseases associated with GC native protein
 Products by Pathway  Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones And Vitamins A And D Pathway antibodies  Metabolism Of Steroid Hormones And Vitamins A And D Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Vitamin D (calciferol) Metabolism Pathway antibodies  Vitamin D (calciferol) Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3699 publications with GC and Neoplasms
 Drug Toxicity Antibodies  >1485 publications with GC and Drug Toxicity
 Carcinoma Antibodies  >1215 publications with GC and Carcinoma
 Brain Diseases Antibodies  >916 publications with GC and Brain Diseases
 Inflammation Antibodies  >763 publications with GC and Inflammation
 Vascular Diseases Antibodies  >631 publications with GC and Vascular Diseases
 Lymphoma Antibodies  >587 publications with GC and Lymphoma
 Necrosis Antibodies  >535 publications with GC and Necrosis
 Liver Diseases Antibodies  >527 publications with GC and Liver Diseases
 Kidney Diseases Antibodies  >361 publications with GC and Kidney Diseases
Organs/Tissues associated with GC native protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7828 publications with GC and Blood
 Liver Antibodies  >2382 publications with GC and Liver
 Kidney Antibodies  >1143 publications with GC and Kidney
 Muscle Antibodies  >1109 publications with GC and Muscle
 Lung Antibodies  >970 publications with GC and Lung
 Heart Antibodies  >771 publications with GC and Heart
 Intestine Antibodies  >592 publications with GC and Intestine
 Ovary Antibodies  >575 publications with GC and Ovary
 Connective Tissue Antibodies  >458 publications with GC and Connective Tissue
 Spleen Antibodies  >424 publications with GC and Spleen
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