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ZA2G native protein :: Zinc-Alpha 2 Glycoprotein Native Protein

Scan QR to view Datasheet Catalog #    MBS145455 ZA2G native protein
Unit / Price
0.001 mg  /  $140 +1 FREE 8GB USB
0.005 mg  /  $205 +1 FREE 8GB USB
0.05 mg  /  $840 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Zinc-Alpha 2 Glycoprotein (ZA2G), Native Protein

★Popular Item★
 Also Known As   

Human Zinc-Alpha 2 Glycoprotein

 Product Synonym Names    ZA2G Human; Zinc-alpha 2 glycoprotein Human; Zn-alpha-2-glycoprotein; Zn-alpha-2-GP; AZGP1; ZAG; Zinc-alpha-2-glycoprotein; ZNGP1; ZA2G
 Product Gene Name   

ZA2G native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    194460
 3D Structure    ModBase 3D Structure for P25311
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 Host    Human Serum
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 Purity/Purification    Greater than 80% as determined by SDS-PAGE.
 Form/Format    ZA2G protein filtered (0.4 um) and lyophilized in 0.5mg/ml in 20mM TRIS and 50mM NaCl, pH 8.0.
Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
 Human Virus Test    Blood samples from each donor have been tested and found negative for HBsAg, anti-HCV, HIV Ag/Ab and syphilis.
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 Preparation and Storage    Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
 Other Notes    Small volumes of ZA2G native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ZA2G native protein

   Description: The Human Zinc-Alpha 2 Glycoprotein produced from Human Serum has a molecular mass of 32.14kDa (calculated without glycosylation) containing 278 amino acid residues.

Introduction: Zinc-alpha-2-glycoprotein (ZAG) is found in body fluids such as serum, sweat, and seminal and breast cyst fluids. It is identical in amino acid sequence to tumor-derived lipid mobilizing factor (LMF), a protein associated with the dramatic loss of adipose body stores in cancer cachexia, and has been shown to stimulate lipolysis by adipocytes in vivo and in vitro. A role for ZAG has been proposed in the regulation of body weight, and age-dependent changes in genetically influenced obesity, and also it regulates melanin production by normal and malignant melanocytes. It has also recently been classified as a novel adipokine in that it is produced by both white and brown fat adipocytes and may act in a local autocrine fashion in the reduction of adiposity in cachexia. Controlling ZAG/LMF's activity could be life-saving in the management of certain cancers and other cachexiainducing conditions, and its possible normal role in body fat store homeostasis is deserving of understanding in its own right. ZAG exhibits a class I major histocompatibility complex (MHC) fold but is a soluble protein rather than being anchored to plasma membranes and does not associate with alpha-2-microglobulin in humans. Like antigen-presenting MHC class I proteins, ZAG has an open apical groove, and X-ray crystallography of human derived ZAG revealed an unidentifiable electron density in a similar position to that occupied by antigenic peptides in classical MHC proteins and glycolipids in isoforms of CD1. This presumptive ligand is not a peptide, and the groove is too small to hold a glycolipid such as is presented by CD1 isoforms. By analogy with all other MHC class I-related proteins that have an open apical groove [some do not ], occupancy by a ligand is probably crucial to ZAG's biological function. Despite all of the structural and biochemical evidence that ZAG binds a ligand, none has so far been found by extraction from protein isolated from biological fluids. This difficulty could be because the ligand is labile, heterogeneous, or readily lost during purification procedures. Knowing more about how ZAG interacts with the compounds it has been found to bind, both natural and artificial, will inform searches for the elusive ligand(s) and its/their role in ZAG's signaling function.
 Product Categories/Family for ZA2G native protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Zinc Finger
NCBI/Uniprot data below describe general gene information for ZA2G. It may not necessarily be applicable to this product.
 NCBI GI #    4502337
 NCBI GeneID    563
 NCBI Accession #    NP_001176.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001185.3 [Other Products]
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 UniProt Primary Accession #    P25311 [Other Products]
 UniProt Secondary Accession #    O60386; Q5XKQ4; Q8N4N0; D6W5T8 [Other Products]
 UniProt Related Accession #    P25311 [Other Products]
 Molecular Weight    34,259 Da
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 NCBI Official Full Name    zinc-alpha-2-glycoprotein
 NCBI Official Synonym Full Names    alpha-2-glycoprotein 1, zinc-binding
 NCBI Official Symbol    AZGP1 [Similar Products]
 NCBI Official Synonym Symbols   
ZAG; ZA2G
[Similar Products]
 NCBI Protein Information    zinc-alpha-2-glycoprotein; Alpha-2-glycoprotein, zinc; Zn-alpha2-glycoprotein; zn-alpha-2-GP; zn-alpha-2-glycoprotein
 UniProt Protein Name    Zinc-alpha-2-glycoprotein
 UniProt Gene Name    AZGP1 [Similar Products]
 UniProt Synonym Gene Names    ZAG; ZNGP1; Zn-alpha-2-GP; Zn-alpha-2-glycoprotein [Similar Products]
 UniProt Entry Name    ZA2G_HUMAN
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 UniProt Comments for ZA2G    AZGP1: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids. Belongs to the MHC class I family.

Protein type: Secreted; Secreted, signal peptide; Cell adhesion

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: extracellular space; plasma membrane; extracellular region; MHC class I protein complex; nucleus

Molecular Function: peptide antigen binding; protein transmembrane transporter activity; glycoprotein binding; antigen binding; ribonuclease activity

Biological Process: retinal homeostasis; negative regulation of cell proliferation; antigen processing and presentation; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of T cell mediated cytotoxicity; immune response; detection of chemical stimulus involved in sensory perception of bitter taste; cell adhesion
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 Research Articles on ZA2G    1. overexpression of AZGP1 suppressed the activation of the mTOR pathway and endogenous FASN-regulated fatty acid synthesis, mitigating the malignant phenotype of LoVo cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ZA2G native proteinDiseases associated with ZA2G native protein
 Reference Product  PubMed Publications
 PIP native protein  >11 publications with ZA2G and PIP
 FETUB native protein  >1 publications with ZA2G and FETUB
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >16 publications with ZA2G and Carcinoma
 Adenocarcinoma Antibodies  >12 publications with ZA2G and Adenocarcinoma
 Prostatic Neoplasms Antibodies  >12 publications with ZA2G and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >9 publications with ZA2G and Breast Neoplasms
 Kidney Diseases Antibodies  >6 publications with ZA2G and Kidney Diseases
 Disease Models, Animal Antibodies  >5 publications with ZA2G and Disease Models, Animal
 Weight Loss Antibodies  >4 publications with ZA2G and Weight Loss
 Necrosis Antibodies  >4 publications with ZA2G and Necrosis
 Immune System Diseases Antibodies  >4 publications with ZA2G and Immune System Diseases
 Pancreatic Neoplasms Antibodies  >3 publications with ZA2G and Pancreatic Neoplasms
Organs/Tissues associated with ZA2G native protein
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >15 publications with ZA2G and Prostate
 Connective Tissue Antibodies  >10 publications with ZA2G and Connective Tissue
 Kidney Antibodies  >7 publications with ZA2G and Kidney
 Liver Antibodies  >6 publications with ZA2G and Liver
 Lung Antibodies  >4 publications with ZA2G and Lung
 Eye Antibodies  >4 publications with ZA2G and Eye
 Brain Antibodies  >2 publications with ZA2G and Brain
 Muscle Antibodies  >2 publications with ZA2G and Muscle
 Stomach Antibodies  >1 publications with ZA2G and Stomach
 Mouth Antibodies  >1 publications with ZA2G and Mouth
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