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ACTN3 native protein :: alpha Actinin Native Protein

Scan QR to view Datasheet Catalog #    MBS536612 ACTN3 native protein
Unit / Price
0.25 mg  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

alpha Actinin (ACTN3), Native Protein

 Also Known As   

alpha Actinin protein

 Product Synonym Names    alpha Actinin 1 protein; ACTN1 protein; FLJ40884 protein
 Product Gene Name   

ACTN3 native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    102574
 3D Structure    ModBase 3D Structure for Q08043
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 Host    Chicken
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 Purity/Purification    > 95% pure
 Form/Format    Supplied in lyophilized form with 10 mM Tris/HCl buffer pH 8.0, 0.2mM CaCl2, 0.2 mM ATP, 1 mM DTT, 0.5% (w/v) SDS
 Concentration    1 mg/ml (lot specific)
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 Source Note    Chicken gizzard
 Protein Type    Native
 Biological Significance    Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
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 Preparation and Storage    Store at 2-8 degree C in lyophilized form. Following reconstitution aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of ACTN3 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ACTN3 native protein

   Purified native Chicken alpha Actinin protein
 Product Categories/Family for ACTN3 native protein    Cell Biology; Native Protein
 Applications Tested/Suitable for ACTN3 native protein   

User optimized

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NCBI/Uniprot data below describe general gene information for ACTN3. It may not necessarily be applicable to this product.
 NCBI GI #    178058
 NCBI GeneID    89
 NCBI Accession #    AAA51585.1 [Other Products]
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 UniProt Primary Accession #    Q08043 [Other Products]
 UniProt Secondary Accession #    Q4KKV2; A6NP77 [Other Products]
 UniProt Related Accession #    Q08043 [Other Products]
 Molecular Weight    95 kDa [Similar Products]
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 NCBI Official Full Name    alpha-actinin
 NCBI Official Synonym Full Names    actinin, alpha 3 (gene/pseudogene)
 NCBI Official Symbol    ACTN3 [Similar Products]
 NCBI Protein Information    alpha-actinin-3
 UniProt Protein Name    Alpha-actinin-3
 UniProt Synonym Protein Names   
Alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein
 Protein Family    Alpha-actinin
 UniProt Gene Name    ACTN3 [Similar Products]
 UniProt Entry Name    ACTN3_HUMAN
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 NCBI Summary for ACTN3    This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the coding allele. The non-functional allele of this gene is associated with elite athlete status. [provided by RefSeq, Feb 2014]
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 UniProt Comments for ACTN3    ACTN3: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Belongs to the alpha-actinin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: focal adhesion; actin filament; pseudopodium; cytosol

Molecular Function: integrin binding; protein binding; protein homodimerization activity; structural constituent of muscle; calcium ion binding; actin binding

Biological Process: focal adhesion formation; regulation of apoptosis; muscle filament sliding
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 Research Articles on ACTN3    1. fatigue-resistant muscle fibers with leaky SR would contribute to non-shivering thermogenesis, providing a tentative explanation for the evolutionary advantage of carrying the ACTN3 577xx gene in a cold climate.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ACTN3 native proteinDiseases associated with ACTN3 native protein
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Disease Name  Pubmed Publications
 Atrophy Antibodies  >5 publications with ACTN3 and Atrophy
 Inflammation Antibodies  >2 publications with ACTN3 and Inflammation
 Kidney Diseases Antibodies  >2 publications with ACTN3 and Kidney Diseases
 Ovarian Neoplasms Antibodies  >2 publications with ACTN3 and Ovarian Neoplasms
 Ovarian Diseases Antibodies  >2 publications with ACTN3 and Ovarian Diseases
 Insulin Resistance Antibodies  >1 publications with ACTN3 and Insulin Resistance
 Fibrosis Antibodies  >1 publications with ACTN3 and Fibrosis
 Fetal Death Antibodies  >1 publications with ACTN3 and Fetal Death
Organs/Tissues associated with ACTN3 native protein
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >132 publications with ACTN3 and Muscle
 Bone Antibodies  >6 publications with ACTN3 and Bone
 Heart Antibodies  >6 publications with ACTN3 and Heart
 Embryonic Tissue Antibodies  >3 publications with ACTN3 and Embryonic Tissue
 Eye Antibodies  >1 publications with ACTN3 and Eye
 Testis Antibodies  >1 publications with ACTN3 and Testis
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