AAR24354.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
26RFa
NCBI Official Synonym Full Names
pyroglutamylated RFamide peptide
NCBI Official Synonym Symbols
NCBI Protein Information
orexigenic neuropeptide QRFP
UniProt Protein Name
Orexigenic neuropeptide QRFP
UniProt Synonym Protein Names
P518
UniProt Entry Name
OX26_HUMAN
NCBI Summary for 26Rfa
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides 26RFa and the N-terminally extended form, 43RFa. Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake in rodents. [provided by RefSeq, Jul 2015]
UniProt Comments for 26Rfa
QRFP: Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland. Belongs to the RFamide neuropeptide family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9q34.12
Cellular Component: extracellular region
Molecular Function: neuropeptide hormone activity; orexigenic neuropeptide QRFP receptor binding
Biological Process: grooming behavior; locomotory behavior; neuropeptide signaling pathway; positive regulation of blood pressure
Research Articles on 26Rfa
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Pathways associated with 26Rfa peptide
Diseases associated with 26Rfa peptide
Organs/Tissues associated with 26Rfa peptide
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