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A1 peptide

Scan QR to view Datasheet Catalog #    MBS843878 A1 peptide
Unit / Price
0.05 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A1, Peptide

 Also Known As   

A1 Blocking Peptide

 Product Gene Name   

A1 peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601056
 3D Structure    ModBase 3D Structure for Q16548
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 Form/Format    50 ug (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal.
Appearance: Colorless liquid
 Concentration    0.2 mg/ml (lot specific)
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 Handling    The peptide solution should be gently mixed before use.
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 Preparation and Storage    At -20 degree C
Shelf Life: 12 months
 Other Notes    Small volumes of A1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for A1 peptide   

Western Blot (WB)

 Application Notes for A1 peptide    The peptide is used for blocking the antibody activity of active A1. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37 degree C
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NCBI/Uniprot data below describe general gene information for A1. It may not necessarily be applicable to this product.
 NCBI GI #    168480072
 NCBI GeneID    597
 NCBI Accession #    NP_001108207.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001114735.1 [Other Products]
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 UniProt Primary Accession #    Q16548 [Other Products]
 UniProt Secondary Accession #    Q6FGZ4; Q6FH19; Q86W13; Q99524 [Other Products]
 UniProt Related Accession #    Q16548 [Other Products]
 Molecular Weight    18,746 Da
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 NCBI Official Full Name    bcl-2-related protein A1 isoform 2
 NCBI Official Synonym Full Names    BCL2-related protein A1
 NCBI Official Symbol    BCL2A1 [Similar Products]
 NCBI Official Synonym Symbols   
GRS; ACC1; ACC2; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5
[Similar Products]
 NCBI Protein Information    bcl-2-related protein A1
 UniProt Protein Name    Bcl-2-related protein A1
 UniProt Synonym Protein Names   
Bcl-2-like protein 5; Bcl2-L-5; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS
 Protein Family    A1-specific pheromone
 UniProt Gene Name    BCL2A1 [Similar Products]
 UniProt Synonym Gene Names    BCL2L5; BFL1; GRS; HBPA1; Bcl2-L-5 [Similar Products]
 UniProt Entry Name    B2LA1_HUMAN
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 NCBI Summary for A1    This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for A1    BCL2A1: Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. Interacts directly with BAK1, BID, BMF and BBC3. Interacts directly with BCL2L11/BIM. Interacts with BAX isoform Sigma. Interacts directly with PMAIP1. By phorbol ester and inflammatory cytokines, such as TNF or IL1B/interleukin-1 beta, but not by growth factors. Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies. Belongs to the Bcl-2 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 15q24.3

Cellular Component: mitochondrial outer membrane

Molecular Function: BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of apoptosis
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 Research Articles on A1    1. Bcl2a1 overexpressing granulocytic MDSCs demonstrated prolonged survival.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with A1 peptideDiseases associated with A1 peptide
 Reference Product  PubMed Publications
 JUN peptide  >16 publications with A1 and JUN
 RELA peptide  >4 publications with A1 and RELA
 NFKB1 peptide  >4 publications with A1 and NFKB1
 BBC3 peptide  >2 publications with A1 and BBC3
 BAK1 peptide  >2 publications with A1 and BAK1
 BIK peptide  >1 publications with A1 and BIK
 JUNB peptide  >1 publications with A1 and JUNB
 TP53 peptide  >1 publications with A1 and TP53
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >22 publications with A1 and Leukemia
 Inflammation Antibodies  >10 publications with A1 and Inflammation
 Necrosis Antibodies  >10 publications with A1 and Necrosis
 Carcinoma Antibodies  >8 publications with A1 and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >5 publications with A1 and Cell Transformation, Neoplastic
 Carcinoma, Squamous Cell Antibodies  >4 publications with A1 and Carcinoma, Squamous Cell
 Neoplasms, Experimental Antibodies  >3 publications with A1 and Neoplasms, Experimental
 Heart Diseases Antibodies  >3 publications with A1 and Heart Diseases
 Liver Diseases Antibodies  >3 publications with A1 and Liver Diseases
 Breast Neoplasms Antibodies  >3 publications with A1 and Breast Neoplasms
Organs/Tissues associated with A1 peptide
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >39 publications with A1 and Blood
 Lymph Node Antibodies  >6 publications with A1 and Lymph Node
 Skin Antibodies  >5 publications with A1 and Skin
 Liver Antibodies  >4 publications with A1 and Liver
 Kidney Antibodies  >4 publications with A1 and Kidney
 Heart Antibodies  >4 publications with A1 and Heart
 Prostate Antibodies  >3 publications with A1 and Prostate
 Bone Marrow Antibodies  >2 publications with A1 and Bone Marrow
 Connective Tissue Antibodies  >2 publications with A1 and Connective Tissue
 Intestine Antibodies  >1 publications with A1 and Intestine
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