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AARS2 peptide

Scan QR to view Datasheet Catalog #    MBS427956 AARS2 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AARS2, Peptide

 Also Known As   

AARS2 Immunizing Peptide

 Product Synonym Names    AARS2; alanyl-tRNA synthetase 2, mitochondrial (putative); AARSL; COXPD8; KIAA1270; MT-ALARS; MTALARS; bA444E17.1; OTTHUMP00000016528; alaRS; alanine tRNA ligase 2, mitochondrial (putative); alanine--tRNA ligase; alanyl-tRNA synthetase like; alanyl-tRNA s
 Product Gene Name   

AARS2 peptide

[Similar Products]
 Antibody/Peptide Pairs    AARS2 peptide (MBS427956) is used for blocking the activity of AARS2 antibody (MBS422922)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-QHRARQAE PVQK
 OMIM    612035
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 Species Reactivity    Human
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of AARS2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for AARS2. It may not necessarily be applicable to this product.
 NCBI GI #    38569417
 NCBI GeneID    57505
 NCBI Accession #    NP_065796.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020745.3 [Other Products]
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 UniProt Secondary Accession #    Q8N198; Q96D02; Q9ULF0; A2RRN5 [Other Products]
 UniProt Related Accession #    Q5JTZ9 [Other Products]
 Molecular Weight    107,340 Da
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 NCBI Official Full Name    alanine--tRNA ligase, mitochondrial
 NCBI Official Synonym Full Names    alanyl-tRNA synthetase 2, mitochondrial
 NCBI Official Symbol    AARS2 [Similar Products]
 NCBI Official Synonym Symbols   
AARSL; LKENP; COXPD8; MTALARS; MT-ALARS
[Similar Products]
 NCBI Protein Information    alanine--tRNA ligase, mitochondrial
 UniProt Protein Name    Alanine--tRNA ligase, mitochondrial
 UniProt Synonym Protein Names   
Alanyl-tRNA synthetase
 UniProt Gene Name    AARS2 [Similar Products]
 UniProt Synonym Gene Names    AlaRS [Similar Products]
 UniProt Entry Name    SYAM_HUMAN
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 NCBI Summary for AARS2    The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8. [provided by RefSeq, Dec 2011]
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 UniProt Comments for AARS2    AARSL: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Defects in AARS2 are the cause of combined oxidative phosphorylation deficiency type 8 (COXPD8). A mitochondrial disease characterized by a lethal infantile hypertrophic cardiomyopathy, generalized muscle dysfunction and some neurologic involvement. The liver is not affected. Belongs to the class-II aminoacyl-tRNA synthetase family.

Protein type: EC 6.1.1.7; Translation; Ligase

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: cytosol; mitochondrion

Molecular Function: alanine-tRNA ligase activity; amino acid binding; ATP binding; metal ion binding; tRNA binding

Biological Process: mitochondrial respiratory chain complex assembly; tRNA modification

Disease: Combined Oxidative Phosphorylation Deficiency 8; Leukoencephalopathy, Progressive, With Ovarian Failure
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 Research Articles on AARS2    1. A new phenotype caused by AARS2 mutations is characterized by leukoencephalopathy and ovarian failure in female patients, indicating that the phenotypic spectrum associated with AARS2 variants is much wider than previously reported.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with AARS2 peptideDiseases associated with AARS2 peptide
 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Mitochondrial TRNA Aminoacylation Pathway antibodies  Mitochondrial TRNA Aminoacylation Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with AARS2 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1 publications with AARS2 and Cardiovascular Diseases
 Brain Diseases Antibodies  >1 publications with AARS2 and Brain Diseases
 Atrophy Antibodies  >1 publications with AARS2 and Atrophy
 Cognition Disorders Antibodies  >1 publications with AARS2 and Cognition Disorders
Organs/Tissues associated with AARS2 peptide
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >3 publications with AARS2 and Muscle
 Heart Antibodies  >1 publications with AARS2 and Heart
 Brain Antibodies  >1 publications with AARS2 and Brain
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