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HSD17B10 peptide :: ABAD / HADH2 Peptide

Scan QR to view Datasheet Catalog #    MBS426725 HSD17B10 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABAD / HADH2 (HSD17B10), Peptide

★Popular Item★
 Also Known As   

ABAD / HADH2 Immunizing Peptide

 Product Synonym Names    HSD17B10; HADH2; ABAD; ERAB; MHBD; 17b-HSD10; hydroxyacyl-Coenzyme A dehydrogenase, type II; type 10 17b-HSD; AB-binding alcohol dehydrogenase; type 10 17beta-hydroxysteroid dehydrogenase; hydroxysteroid (17-beta) dehydrogenase 10; RP3-339A18.2; 17b-HSD10; ABAD / HADH2
 Product Gene Name   

HSD17B10 peptide

[Similar Products]
 Product Synonym Gene Name    ABAD; HADH2 [Similar Products]
 Antibody/Peptide Pairs    ABAD / HADH2 peptide (MBS426725) is used for blocking the activity of ABAD/HADH2 antibody (MBS421448)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    CIRLDGAIRM QP
 OMIM    300220
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 Species Reactivity    Human, Mouse, Rat, Dog, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of HSD17B10 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for HSD17B10. It may not necessarily be applicable to this product.
 NCBI GI #    4758504
 NCBI GeneID    3028
 NCBI Accession #    NP_004484.1 [Other Products]
 NCBI Related Accession #    NP_001032900.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004493.2 [Other Products]
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 UniProt Secondary Accession #    Q5H927; Q6IBS9; Q8TCV9; Q96HD5 [Other Products]
 UniProt Related Accession #    Q99714 [Other Products]
 Molecular Weight    25,984 Da
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 NCBI Official Full Name    3-hydroxyacyl-CoA dehydrogenase type-2 isoform 1
 NCBI Official Synonym Full Names    hydroxysteroid (17-beta) dehydrogenase 10
 NCBI Official Symbol    HSD17B10 [Similar Products]
 NCBI Official Synonym Symbols   
ABAD; CAMR; ERAB; HCD2; MHBD; HADH2; MRPP2; MRX17; MRX31; SCHAD; MRXS10; SDR5C1; 17b-HSD10; DUPXp11.22
[Similar Products]
 NCBI Protein Information    3-hydroxyacyl-CoA dehydrogenase type-2
 UniProt Protein Name    3-hydroxyacyl-CoA dehydrogenase type-2
 UniProt Synonym Protein Names   
17-beta-hydroxysteroid dehydrogenase 10 (EC:1.1.1.51); 17-beta-HSD 10; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase (EC:1.1.1.178); 3-hydroxyacyl-CoA dehydrogenase type II; Endoplasmic reticulum-associated amyloid beta-peptide-binding protein; Mitochondrial ribonuclease P protein 2; Mitochondrial RNase P protein 2; Short chain dehydrogenase/reductase family 5C member 1; Short-chain type dehydrogenase/reductase XH98G2; Type II HADH
 Protein Family    3-hydroxyacyl-CoA dehydrogenase
 UniProt Gene Name    HSD17B10 [Similar Products]
 UniProt Synonym Gene Names    ERAB; HADH2; MRPP2; SCHAD; SDR5C1; XH98G2; 17-beta-HSD 10; Mitochondrial RNase P protein 2 [Similar Products]
 UniProt Entry Name    HCD2_HUMAN
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 NCBI Summary for HSD17B10    This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]
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 UniProt Comments for HSD17B10    HADH2: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Defects in HSD17B10 are the cause of 2-methyl-3- hydroxybutyryl-CoA dehydrogenase deficiency (MHBD deficiency). MHBD deficiency leads to neurological abnormalities, including psychomotor retardation, and, in virtually all patients, loss of mental and motor skills. Defects in HSD17B10 are the cause of mental retardation syndromic X-linked type 10 (MRXS10). MRXS10 is characterized by mild mental retardation, choreoathetosis and abnormal behavior. A chromosomal microduplication involving HSD17B10 and HUWE1 is the cause of mental retardation X-linked type 17 (MRX17); also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub- average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X- linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non- syndromic X-linked mental retardation. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.1.1.51; Oxidoreductase; EC 1.1.1.178; Mitochondrial; EC 1.1.1.35; Amino Acid Metabolism - valine, leucine and isoleucine degradation

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: cytoplasm; mitochondrial matrix; mitochondrion; plasma membrane

Molecular Function: 3(or 17)beta-hydroxysteroid dehydrogenase activity; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity; 3-hydroxyacyl-CoA dehydrogenase activity; 7-alpha-hydroxysteroid dehydrogenase activity; acetoacetyl-CoA reductase activity; beta-amyloid binding; estradiol 17-beta-dehydrogenase activity; estrogen receptor binding; identical protein binding; NAD binding; protein binding; steroid binding

Biological Process: branched chain family amino acid catabolic process; cell aging; Leydig cell differentiation; lipid metabolic process; protein homotetramerization

Disease: 17-beta-hydroxysteroid Dehydrogenase X Deficiency; Mental Retardation, X-linked, Syndromic 10
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 Research Articles on HSD17B10    1. upon exposure to E2, ERalpha rapidly localizes to mitochondria, in which it interacts with HSD17B10 to modulate the expression of mitochondrial RNA transcripts.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HSD17B10 peptidePathways associated with HSD17B10 peptide
 Reference Product  PubMed Publications
 APP peptide  >3 publications with HSD17B10 and APP
 HUWE1 peptide  >2 publications with HSD17B10 and HUWE1
 SLC25A20 peptide  >1 publications with HSD17B10 and SLC25A20
 ECHS1 peptide  >1 publications with HSD17B10 and ECHS1
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Branched-chain Amino Acid Catabolism Pathway antibodies  Branched-chain Amino Acid Catabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 L-isoleucine Degradation I Pathway antibodies  L-isoleucine Degradation I Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
Diseases associated with HSD17B10 peptideOrgans/Tissues associated with HSD17B10 peptide
 Disease Name  Pubmed Publications
 Neurobehavioral Manifestations Antibodies  >10 publications with HSD17B10 and Neurobehavioral Manifestations
 Cardiovascular Diseases Antibodies  >5 publications with HSD17B10 and Cardiovascular Diseases
 Hydroxyacyl-CoA Dehydrogenase, Type 2, Deficiency Antibodies  >5 publications with HSD17B10 and Hydroxyacyl-CoA Dehydrogenase, Type 2, Deficiency
 Heart Diseases Antibodies  >3 publications with HSD17B10 and Heart Diseases
 Fatty Liver Antibodies  >3 publications with HSD17B10 and Fatty Liver
 Liver Diseases Antibodies  >3 publications with HSD17B10 and Liver Diseases
 Abnormalities, Multiple Antibodies  >2 publications with HSD17B10 and Abnormalities, Multiple
 Infertility, Male Antibodies  >1 publications with HSD17B10 and Infertility, Male
 Learning Disorders Antibodies  >1 publications with HSD17B10 and Learning Disorders
 Necrosis Antibodies  >1 publications with HSD17B10 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >31 publications with HSD17B10 and Brain
 Blood Antibodies  >8 publications with HSD17B10 and Blood
 Prostate Antibodies  >7 publications with HSD17B10 and Prostate
 Muscle Antibodies  >7 publications with HSD17B10 and Muscle
 Liver Antibodies  >7 publications with HSD17B10 and Liver
 Heart Antibodies  >4 publications with HSD17B10 and Heart
 Testis Antibodies  >3 publications with HSD17B10 and Testis
 Nerve Antibodies  >3 publications with HSD17B10 and Nerve
 Vascular Antibodies  >3 publications with HSD17B10 and Vascular
 Bone Antibodies  >3 publications with HSD17B10 and Bone
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