NP_001157413.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ATP-binding cassette sub-family B member 5 isoform 1
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family B (MDR/TAP), member 5
NCBI Official Synonym Symbols
ABCB5beta; EST422562; ABCB5alpha [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family B member 5; ABCB5 P-gp; P-glycoprotein ABCB5; ATP-binding cassette protein
UniProt Protein Name
ATP-binding cassette sub-family B member 5
UniProt Synonym Protein Names
ABCB5 P-gp; P-glycoprotein ABCB5
UniProt Entry Name
ABCB5_HUMAN
NCBI Summary for ABCB5
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]
UniProt Comments for ABCB5
Function: Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas. Ref.1 Ref.4 Ref.10 Ref.11
Subcellular location: Cell membrane; Multi-pass membrane protein Ref.1.
Tissue specificity: Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues. Ref.1 Ref.2
Miscellaneous: Depletion of ABCB5 by RNAi increases the sensitivity to several drugs of a subset of melanoma cells.
Sequence similarities: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Contains 1 ABC transmembrane type-1 domain.Contains 2 ABC transporter domains.
Caution: Was named ABCB1 by some authors.
Sequence caution: The sequence AAN76500.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAQ03033.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
Research Articles on ABCB5
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Pathways associated with ABCB5 peptide
Diseases associated with ABCB5 peptide
Organs/Tissues associated with ABCB5 peptide
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