NP_005836.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
88,138 Da
NCBI Official Full Name
multidrug resistance-associated protein 4 isoform 1
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 4
NCBI Protein Information
multidrug resistance-associated protein 4
UniProt Protein Name
Multidrug resistance-associated protein 4
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B
UniProt Synonym Gene Names
UniProt Entry Name
MRP4_HUMAN
NCBI Summary for ABCC4
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
UniProt Comments for ABCC4
ABCC4: a widely-expressed multi-pass membrane protein. An organic anion pump involved in cellular detoxification. Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.
Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral; Transporter, ABC family
Chromosomal Location of Human Ortholog: 13q32
Cellular Component: basolateral plasma membrane; integral to membrane; membrane; plasma membrane; platelet dense granule membrane
Molecular Function: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; anion transmembrane-transporting ATPase activity; ATP binding; ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
Biological Process: cilium biogenesis; platelet degranulation; prostaglandin secretion; transmembrane transport
Research Articles on ABCC4
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Products associated with ABCC4 blocking peptide
Pathways associated with ABCC4 blocking peptide
Diseases associated with ABCC4 blocking peptide
Organs/Tissues associated with ABCC4 blocking peptide
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