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ABCE1 peptide :: ABCE1 / RNase L Peptide

Scan QR to view Datasheet Catalog #    MBS425125 ABCE1 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCE1 / RNase L, Peptide

 Also Known As   

ABCE1 / RNase L Immunizing Peptide

 Product Synonym Names    ABCE1; ATP-binding cassette, sub-family E (OABP), member 1; ABC38; OABP; RLI; RNASEL1; RNASELI; RNS4I; ATP-binding cassette, sub-family E, member 1; RNase L inhibitor; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor; ABCE1 / RNase L
 Product Gene Name   

ABCE1 peptide

[Similar Products]
 Product Synonym Gene Name    RNase L [Similar Products]
 Antibody/Peptide Pairs    ABCE1 / RNase L peptide (MBS425125) is used for blocking the activity of ABCE1/RNase L antibody (MBS422004)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    NHDKCKPKKC RQEC
 OMIM    601213
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 Species Reactivity    Human, Mouse, Rat, Dog, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of ABCE1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ABCE1. It may not necessarily be applicable to this product.
 NCBI GI #    108773782
 NCBI GeneID    6059
 NCBI Accession #    NP_002931.2 [Other Products]
 NCBI Related Accession #    NP_001035809.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002940.2 [Other Products]
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 UniProt Secondary Accession #    O88793; Q13181; Q13864; Q6NR76; Q96AL0; Q96B10; Q99K66 [Other Products]
 UniProt Related Accession #    P61221 [Other Products]
 Molecular Weight    67,314 Da
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 NCBI Official Full Name    ATP-binding cassette sub-family E member 1
 NCBI Official Synonym Full Names    ATP binding cassette subfamily E member 1
 NCBI Official Symbol    ABCE1 [Similar Products]
 NCBI Official Synonym Symbols   
RLI; OABP; ABC38; RNS4I; RNASEL1; RNASELI
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family E member 1
 UniProt Protein Name    ATP-binding cassette sub-family E member 1
 UniProt Synonym Protein Names   
2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I
 Protein Family    ABC transporter E family
 UniProt Gene Name    ABCE1 [Similar Products]
 UniProt Synonym Gene Names    RLI; RNASEL1; RNASELI; RNS4I; RNS4I [Similar Products]
 UniProt Entry Name    ABCE1_HUMAN
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 NCBI Summary for ABCE1    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCE1    ABCE1: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. Belongs to the ABC transporter superfamily. ABCE family.

Chromosomal Location of Human Ortholog: 4q31

Cellular Component: cytoplasm; membrane; mitochondrial matrix; mitochondrion

Molecular Function: ATP binding; ATPase activity; protein binding; ribonuclease inhibitor activity

Biological Process: negative regulation of catalytic activity; response to virus; RNA catabolic process; transmembrane transport; viral reproduction
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 Research Articles on ABCE1    1. Downregulation of ABCE1 via siRNA affects the sensitivity of lung cancer cells against chemotherapeutic agents.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ABCE1 peptideDiseases associated with ABCE1 peptide
 Products by Pathway  Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >6 publications with ABCE1 and Lung Neoplasms
 Adenocarcinoma Antibodies  >5 publications with ABCE1 and Adenocarcinoma
 Lung Diseases Antibodies  >5 publications with ABCE1 and Lung Diseases
 Neoplasm Metastasis Antibodies  >4 publications with ABCE1 and Neoplasm Metastasis
 Liver Diseases Antibodies  >3 publications with ABCE1 and Liver Diseases
 Hepatitis Antibodies  >2 publications with ABCE1 and Hepatitis
 Liver Neoplasms Antibodies  >2 publications with ABCE1 and Liver Neoplasms
 Inflammation Antibodies  >2 publications with ABCE1 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >2 publications with ABCE1 and Carcinoma, Hepatocellular
 Prostatic Diseases Antibodies  >2 publications with ABCE1 and Prostatic Diseases
Organs/Tissues associated with ABCE1 peptide
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >9 publications with ABCE1 and Lung
 Blood Antibodies  >8 publications with ABCE1 and Blood
 Liver Antibodies  >3 publications with ABCE1 and Liver
 Muscle Antibodies  >3 publications with ABCE1 and Muscle
 Brain Antibodies  >3 publications with ABCE1 and Brain
 Prostate Antibodies  >2 publications with ABCE1 and Prostate
 Skin Antibodies  >2 publications with ABCE1 and Skin
 Bone Marrow Antibodies  >1 publications with ABCE1 and Bone Marrow
 Thyroid Antibodies  >1 publications with ABCE1 and Thyroid
 Pharynx Antibodies  >1 publications with ABCE1 and Pharynx
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