NP_000670.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,836 Da
NCBI Official Full Name
alpha-1B adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor alpha 1B
NCBI Protein Information
alpha-1B adrenergic receptor
UniProt Protein Name
Alpha-1B adrenergic receptor
UniProt Synonym Protein Names
Alpha-1B adrenoreceptor; Alpha-1B adrenoceptor
UniProt Synonym Gene Names
UniProt Entry Name
ADA1B_HUMAN
NCBI Summary for ADRA1B
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]
UniProt Comments for ADRA1B
ADRA1B: a G protein-coupled catecholamine receptor that activates mitogenic responses and regulates growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. Can induce neoplastic transformation when transfected into cell lines. Can regulate the phosphorylation status of the STAT3 pathway. Mediates blood pressure and aorta contractile responses induced by alpha-1 agonists. Activates a phosphatidylinositol second messenger system.
Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5q33.3
Cellular Component: integral to plasma membrane; nuclear membrane; nucleus; plasma membrane
Molecular Function: alpha1-adrenergic receptor activity; protein heterodimerization activity
Biological Process: cell proliferation; cell-cell signaling; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); glucose homeostasis; multicellular organismal development; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; positive regulation of MAPKKK cascade; positive regulation of smooth muscle contraction; positive regulation of vasoconstriction
Research Articles on ADRA1B
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Products associated with ADRA1B blocking peptide
Pathways associated with ADRA1B blocking peptide
Diseases associated with ADRA1B blocking peptide
Organs/Tissues associated with ADRA1B blocking peptide
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