NP_001129.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
agouti-related protein
NCBI Official Synonym Full Names
agouti related neuropeptide
NCBI Protein Information
agouti-related protein
UniProt Protein Name
Agouti-related protein
UniProt Synonym Gene Names
UniProt Entry Name
AGRP_HUMAN
NCBI Summary for AGRP
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]
UniProt Comments for AGRP
AGRP: Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. Genetic variations in AGRP may be a cause of obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Protein type: Hormone; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 16q22
Cellular Component: extracellular space; Golgi lumen
Molecular Function: neuropeptide hormone activity; receptor binding
Biological Process: feeding behavior; neuropeptide signaling pathway
Disease: Obesity
Research Articles on AGRP
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Products associated with AGRP peptide
Pathways associated with AGRP peptide
Diseases associated with AGRP peptide
Organs/Tissues associated with AGRP peptide
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