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AIM2 peptide

Scan QR to view Datasheet Catalog #    MBS427222 AIM2 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AIM2, Peptide

 Also Known As   

AIM2 Immunizing Peptide

 Product Synonym Names    AIM2; absent in melanoma 2; PYHIN4
 Product Gene Name   

AIM2 peptide

[Similar Products]
 Antibody/Peptide Pairs    AIM2 peptide (MBS427222) is used for blocking the activity of AIM2 antibody (MBS422316)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-GEKLQLTS GVHSTIK
 OMIM    604578
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 Species Reactivity    Human
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of AIM2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for AIM2. It may not necessarily be applicable to this product.
 NCBI GI #    4757734
 NCBI GeneID    9447
 NCBI Accession #    NP_004824.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004833.1 [Other Products]
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 UniProt Secondary Accession #    Q5T3V9; Q96FG9; A8K7M7 [Other Products]
 UniProt Related Accession #    O14862 [Other Products]
 Molecular Weight    38,954 Da
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 NCBI Official Full Name    interferon-inducible protein AIM2
 NCBI Official Synonym Full Names    absent in melanoma 2
 NCBI Official Symbol    AIM2 [Similar Products]
 NCBI Official Synonym Symbols   
PYHIN4
[Similar Products]
 NCBI Protein Information    interferon-inducible protein AIM2
 UniProt Protein Name    Interferon-inducible protein AIM2
 UniProt Synonym Protein Names   
Absent in melanoma 2
 Protein Family    Protein
 UniProt Gene Name    AIM2 [Similar Products]
 UniProt Entry Name    AIM2_HUMAN
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 NCBI Summary for AIM2    AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AIM2    AIM2: a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Induced by interferon gamma. Defects in AIM2 may be a cause of microsatellite unstable colon cancers. AIM2 and various NOD-like receptors form multiprotein complexes called inflammasomes, which mediate caspase-1-dependent processing of pro-IL-1beta.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: double-stranded DNA binding; identical protein binding; protein binding

Biological Process: activation of innate immune response; activation of NF-kappaB transcription factor; apoptosis; immune response; inflammatory response; inhibition of NF-kappaB transcription factor; innate immune response; interleukin-1 beta secretion; positive regulation of defense response to virus by host; positive regulation of interleukin-1 beta production; positive regulation of interleukin-1 beta secretion; positive regulation of protein oligomerization; tumor necrosis factor-mediated signaling pathway
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 Research Articles on AIM2    1. pyrin domain drives both filament formation and dsDNA binding
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AIM2 peptidePathways associated with AIM2 peptide
 Reference Product  PubMed Publications
 CASP1 peptide  >226 publications with AIM2 and CASP1
 NLRP3 peptide  >208 publications with AIM2 and NLRP3
 NLRC4 peptide  >94 publications with AIM2 and NLRC4
 NLRP1 peptide  >53 publications with AIM2 and NLRP1
 PYCARD peptide  >40 publications with AIM2 and PYCARD
 DDX58 peptide  >6 publications with AIM2 and DDX58
 EIF2AK2 peptide  >2 publications with AIM2 and EIF2AK2
 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammasomes Pathway antibodies  Inflammasomes Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 NOD Pathway antibodies  NOD Pathway Diagram
 Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways antibodies  Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways Diagram
 The AIM2 Inflammasome Pathway antibodies  The AIM2 Inflammasome Pathway Diagram
Diseases associated with AIM2 peptideOrgans/Tissues associated with AIM2 peptide
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >144 publications with AIM2 and Inflammation
 Necrosis Antibodies  >23 publications with AIM2 and Necrosis
 Disease Models, Animal Antibodies  >22 publications with AIM2 and Disease Models, Animal
 Nervous System Diseases Antibodies  >13 publications with AIM2 and Nervous System Diseases
 Atherosclerosis Antibodies  >11 publications with AIM2 and Atherosclerosis
 Lung Diseases Antibodies  >9 publications with AIM2 and Lung Diseases
 Pneumonia Antibodies  >6 publications with AIM2 and Pneumonia
 Breast Neoplasms Antibodies  >5 publications with AIM2 and Breast Neoplasms
 Liver Cirrhosis Antibodies  >5 publications with AIM2 and Liver Cirrhosis
 Fibrosis Antibodies  >5 publications with AIM2 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >53 publications with AIM2 and Blood
 Bone Antibodies  >28 publications with AIM2 and Bone
 Lung Antibodies  >20 publications with AIM2 and Lung
 Brain Antibodies  >19 publications with AIM2 and Brain
 Intestine Antibodies  >11 publications with AIM2 and Intestine
 Mouth Antibodies  >9 publications with AIM2 and Mouth
 Lymph Node Antibodies  >5 publications with AIM2 and Lymph Node
 Spleen Antibodies  >4 publications with AIM2 and Spleen
 Connective Tissue Antibodies  >2 publications with AIM2 and Connective Tissue
 Cervix Antibodies  >1 publications with AIM2 and Cervix
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