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MAGI2 peptide :: AIP1 / MAGI2 Peptide

Scan QR to view Datasheet Catalog #    MBS426315 MAGI2 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AIP1 / MAGI2, Peptide

 Also Known As   

AIP1 / MAGI2 Immunizing Peptide

 Product Synonym Names    MAGI2; AIP1; ARIP1; MAGI-2; ACVRIP1; KIAA0705; atrophin-1 interacting protein 1; activin receptor interacting p; atrophin-1 interacting protein A; activin receptor interacting protein 1; membrane associated guanylate kinase 2; likely ortholog of mouse act; AIP1 / MAGI2
 Product Gene Name   

MAGI2 peptide

[Similar Products]
 Product Synonym Gene Name    AIP1 [Similar Products]
 Antibody/Peptide Pairs    AIP1 / MAGI2 peptide (MBS426315) is used for blocking the activity of AIP1/MAGI2 antibody (MBS421010)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-PSVLKPGA SAASR
 OMIM    606382
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 Species Reactivity    Human
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of MAGI2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for MAGI2. It may not necessarily be applicable to this product.
 NCBI GI #    27436957
 NCBI GeneID    9863
 NCBI Accession #    NP_036433.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012301.3 [Other Products]
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 UniProt Secondary Accession #    O60434; O60510; Q86UI7; Q9NP44; Q9UDQ5; Q9UDU1; A4D1C1; A7E2C3 [Other Products]
 UniProt Related Accession #    Q86UL8 [Other Products]
 Molecular Weight    157,236 Da
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 NCBI Official Full Name    membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 1
 NCBI Official Synonym Full Names    membrane associated guanylate kinase, WW and PDZ domain containing 2
 NCBI Official Symbol    MAGI2 [Similar Products]
 NCBI Official Synonym Symbols   
AIP1; AIP-1; ARIP1; SSCAM; MAGI-2; ACVRIP1
[Similar Products]
 NCBI Protein Information    membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
 UniProt Protein Name    Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
 UniProt Synonym Protein Names   
Atrophin-1-interacting protein 1; AIP-1; Atrophin-1-interacting protein A; Membrane-associated guanylate kinase inverted 2; MAGI-2
 Protein Family    Membrane-associated guanylate kinase, WW and PDZ domain-containing protein
 UniProt Gene Name    MAGI2 [Similar Products]
 UniProt Synonym Gene Names    ACVRINP1; AIP1; KIAA0705; AIP-1; MAGI-2 [Similar Products]
 UniProt Entry Name    MAGI2_HUMAN
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 NCBI Summary for MAGI2    The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAGI2    AIP1: a scaffold molecule at synaptic junctions that apparently couples neurotransmitter receptors and cell adhesion proteins. Contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. Contains two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. This protein is brain specific, where it appears to be widely expressed in both neurons and glia. Enhances the ability of PTEN to suppress AKT1 activation. Two splice-variant isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q21

Cellular Component: cytoplasm; dendrite; late endosome; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; protein complex; synapse; tight junction

Molecular Function: beta-1 adrenergic receptor binding; phosphatase binding; protein binding; receptor signaling complex scaffold activity; SMAD binding

Biological Process: negative regulation of activin receptor signaling pathway; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of protein kinase B signaling cascade; positive regulation of phosphoprotein phosphatase activity; positive regulation of receptor internalization; protein heterooligomerization; receptor clustering
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 Research Articles on MAGI2    1. The expression of MAGI2 mRNA was significantly down-regulated in PC3, LNCaP and DU-145 PCa cell lines.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MAGI2 peptidePathways associated with MAGI2 peptide
 Reference Product  PubMed Publications
 PTEN peptide  >15 publications with MAGI2 and PTEN
 CTNNB1 peptide  >9 publications with MAGI2 and CTNNB1
 RAPGEF2 peptide  >3 publications with MAGI2 and RAPGEF2
 CACNG2 peptide  >2 publications with MAGI2 and CACNG2
 SPTAN1 peptide  >2 publications with MAGI2 and SPTAN1
 Products by Pathway  Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Nephrin Interactions Pathway antibodies  Nephrin Interactions Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
Diseases associated with MAGI2 peptideOrgans/Tissues associated with MAGI2 peptide
 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >4 publications with MAGI2 and Chromosome Aberrations
 Schizophrenia Antibodies  >4 publications with MAGI2 and Schizophrenia
 Proteinuria Antibodies  >3 publications with MAGI2 and Proteinuria
 Carcinoma, Hepatocellular Antibodies  >3 publications with MAGI2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >3 publications with MAGI2 and Liver Neoplasms
 Lung Diseases Antibodies  >3 publications with MAGI2 and Lung Diseases
 Liver Diseases Antibodies  >3 publications with MAGI2 and Liver Diseases
 Fibrosis Antibodies  >2 publications with MAGI2 and Fibrosis
 Kidney Diseases Antibodies  >2 publications with MAGI2 and Kidney Diseases
 Abnormalities, Multiple Antibodies  >2 publications with MAGI2 and Abnormalities, Multiple
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >33 publications with MAGI2 and Brain
 Nerve Antibodies  >21 publications with MAGI2 and Nerve
 Kidney Antibodies  >10 publications with MAGI2 and Kidney
 Eye Antibodies  >5 publications with MAGI2 and Eye
 Embryonic Tissue Antibodies  >4 publications with MAGI2 and Embryonic Tissue
 Lung Antibodies  >3 publications with MAGI2 and Lung
 Intestine Antibodies  >3 publications with MAGI2 and Intestine
 Prostate Antibodies  >3 publications with MAGI2 and Prostate
 Placenta Antibodies  >1 publications with MAGI2 and Placenta
 Testis Antibodies  >1 publications with MAGI2 and Testis
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