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AKR1C3 peptide

Scan QR to view Datasheet Catalog #    MBS425848 AKR1C3 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AKR1C3, Peptide

 Also Known As   

AKR1C3 Immunizing Peptide

 Product Synonym Names    AKR1C3; DD3; HAKRB; HAKRe; HA1753; HSD17B5; hluPGFS; KIAA0119; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); prostaglandin F synthase; dihydrodiol dehydrogenase 3; chlordecone reductase homolog; hydroxysteroid (1
 Product Gene Name   

AKR1C3 peptide

[Similar Products]
 Antibody/Peptide Pairs    AKR1C3 peptide (MBS425848) is used for blocking the activity of AKR1C3 antibody (MBS421221)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    CFASHPNYPY SDEY
 OMIM    603966
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 Species Reactivity    Human
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of AKR1C3 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for AKR1C3. It may not necessarily be applicable to this product.
 NCBI GI #    24497583
 NCBI GeneID    8644
 NCBI Accession #    NP_003730.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_003739.5 [Other Products]
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 UniProt Secondary Accession #    Q5T2L1; Q96DJ1; Q96KI8; Q99530; Q9UCX1; Q9UII3; Q9UKL9; A8K2V0; B4DL37 [Other Products]
 UniProt Related Accession #    P42330 [Other Products]
 Molecular Weight    23,364 Da
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 NCBI Official Full Name    aldo-keto reductase family 1 member C3 isoform 1
 NCBI Official Synonym Full Names    aldo-keto reductase family 1, member C3
 NCBI Official Symbol    AKR1C3 [Similar Products]
 NCBI Official Synonym Symbols   
DD3; DDX; PGFS; HAKRB; HAKRe; HA1753; HSD17B5; hluPGFS
[Similar Products]
 NCBI Protein Information    aldo-keto reductase family 1 member C3
 UniProt Protein Name    Aldo-keto reductase family 1 member C3
 UniProt Synonym Protein Names   
17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2 (EC:1.1.1.357
 Protein Family    Aldo-keto reductase family
 UniProt Gene Name    AKR1C3 [Similar Products]
 UniProt Synonym Gene Names    DDH1; HSD17B5; KIAA0119; PGFS; PGFS [Similar Products]
 UniProt Entry Name    AK1C3_HUMAN
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 NCBI Summary for AKR1C3    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for AKR1C3    AKR1C3: Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. Belongs to the aldo/keto reductase family.

Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.1.1.149; Lipid Metabolism - arachidonic acid; Oxidoreductase

Chromosomal Location of Human Ortholog: 10p15-p14

Cellular Component: cytoplasm; cytosol; intracellular; nucleus

Molecular Function: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity; 3(or 17)-alpha-hydroxysteroid dehydrogenase activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity; aldehyde reductase activity; aldo-keto reductase activity; delta4-3-oxosteroid 5beta-reductase activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; ketoreductase activity; ketosteroid monooxygenase activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; phenanthrene 9,10-monooxygenase activity; prostaglandin-F synthase activity; retinal dehydrogenase activity; retinol dehydrogenase activity; testosterone 17-beta-dehydrogenase (NADP+) activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

Biological Process: cellular response to starvation; cyclooxygenase pathway; farnesol catabolic process; G-protein coupled receptor protein signaling pathway; keratinocyte differentiation; male gonad development; multicellular organismal macromolecule metabolic process; positive regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; progesterone metabolic process; prostaglandin metabolic process; protein import into nucleus, translocation; regulation of retinoic acid receptor signaling pathway; response to nutrient; retinal metabolic process; retinoid metabolic process; retinol metabolic process; steroid metabolic process
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 Research Articles on AKR1C3    1. AKR1C3 expression is elevated in prostate cancer cell lines and primary prostate cancer, suggesting a link between AKR1C3 levels and the epigenetic status in prostate cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with AKR1C3 peptideDiseases associated with AKR1C3 peptide
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Benzo(a)pyrene Metabolism Pathway antibodies  Benzo(a)pyrene Metabolism Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >55 publications with AKR1C3 and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >32 publications with AKR1C3 and Breast Neoplasms
 Prostatic Neoplasms, Castration-Resistant Antibodies  >23 publications with AKR1C3 and Prostatic Neoplasms, Castration-Resistant
 Adenocarcinoma Antibodies  >20 publications with AKR1C3 and Adenocarcinoma
 Neoplasms, Hormone-Dependent Antibodies  >15 publications with AKR1C3 and Neoplasms, Hormone-Dependent
 Inflammation Antibodies  >14 publications with AKR1C3 and Inflammation
 Obesity Antibodies  >12 publications with AKR1C3 and Obesity
 Neoplasms, Experimental Antibodies  >11 publications with AKR1C3 and Neoplasms, Experimental
 Gastrointestinal Diseases Antibodies  >10 publications with AKR1C3 and Gastrointestinal Diseases
 Endometriosis Antibodies  >9 publications with AKR1C3 and Endometriosis
Organs/Tissues associated with AKR1C3 peptide
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >101 publications with AKR1C3 and Prostate
 Blood Antibodies  >37 publications with AKR1C3 and Blood
 Liver Antibodies  >32 publications with AKR1C3 and Liver
 Lung Antibodies  >24 publications with AKR1C3 and Lung
 Ovary Antibodies  >22 publications with AKR1C3 and Ovary
 Adipose Tissue Antibodies  >17 publications with AKR1C3 and Adipose Tissue
 Uterus Antibodies  >17 publications with AKR1C3 and Uterus
 Skin Antibodies  >15 publications with AKR1C3 and Skin
 Connective Tissue Antibodies  >15 publications with AKR1C3 and Connective Tissue
 Adrenal Gland Antibodies  >13 publications with AKR1C3 and Adrenal Gland
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