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AKR1C4 peptide

Scan QR to view Datasheet Catalog #    MBS426789 AKR1C4 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AKR1C4, Peptide

 Also Known As   

AKR1C4 Immunizing Peptide

 Product Synonym Names    AKR1C4; aldo-keto reductase family 1, member C4; HGNC: 387; 3-alpha-HSD; C11; CDR; CHDR; DD4; HAKRA; MGC22581; 3-alpha hydroxysteroid dehydrogenase, type I; 3 alpha-hydroxysteroid dehydrogenase/dihydrodiol dehydrogenase 4; 3-alpha-hydroxysteroid dehydroge
 Product Gene Name   

AKR1C4 peptide

[Similar Products]
 Antibody/Peptide Pairs    AKR1C4 peptide (MBS426789) is used for blocking the activity of AKR1C4 antibody (MBS421331)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    DPKYQRVELN DGH-C
 OMIM    600451
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 Species Reactivity    Human
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of AKR1C4 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for AKR1C4. It may not necessarily be applicable to this product.
 NCBI GI #    24497585
 NCBI GeneID    1109
 NCBI Accession #    NP_001809.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001818.2 [Other Products]
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 UniProt Secondary Accession #    Q5T6A3; Q8WW84; Q9NS54 [Other Products]
 UniProt Related Accession #    P17516; AAB47003 [Other Products]
 Molecular Weight    37,067 Da
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 NCBI Official Full Name    aldo-keto reductase family 1 member C4
 NCBI Official Synonym Full Names    aldo-keto reductase family 1, member C4
 NCBI Official Symbol    AKR1C4 [Similar Products]
 NCBI Official Synonym Symbols   
C11; CDR; DD4; CHDR; DD-4; HAKRA; 3-alpha-HSD
[Similar Products]
 NCBI Protein Information    aldo-keto reductase family 1 member C4
 UniProt Protein Name    Aldo-keto reductase family 1 member C4
 UniProt Synonym Protein Names   
3-alpha-HSD1; 3-alpha-hydroxysteroid dehydrogenase type I (EC:1.1.1.357); Chlordecone reductase (EC:1.1.1.225); CDR; Dihydrodiol dehydrogenase 4; DD-4; DD4; HAKRA
 Protein Family    Aldo-keto reductase family
 UniProt Gene Name    AKR1C4 [Similar Products]
 UniProt Synonym Gene Names    CHDR; CDR; DD-4; DD4 [Similar Products]
 UniProt Entry Name    AK1C4_HUMAN
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 NCBI Summary for AKR1C4    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AKR1C4    AKR1C4: Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. Defects in AKR1C4 are a cause of 46,XY sex reversal type 8 (SRXY8). A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. AKR1C4 mutations may act as modifier of disease severity in SRXY8 patients. A splicing mutation resulting in loss of exon 2 has been found in affected individuals also carrying mutation Val-79 in AKR1C2 (PubMed:21802064). Belongs to the aldo/keto reductase family.

Protein type: Lipid Metabolism - primary bile acid biosynthesis; Lipid Metabolism - C21-steroid hormone; EC 1.1.1.357; EC 1.1.1.225; Oxidoreductase; Lipid Metabolism - androgen and estrogen; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 10p15.1

Cellular Component: cytoplasm; cytosol

Molecular Function: 3(or 17)-alpha-hydroxysteroid dehydrogenase activity; aldo-keto reductase activity; bile acid transmembrane transporter activity; chlordecone reductase activity; electron carrier activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; retinal dehydrogenase activity

Biological Process: androgen metabolic process; bile acid and bile salt transport; bile acid biosynthetic process; retinoid metabolic process; steroid metabolic process

Disease: 46,xy Sex Reversal 8
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 Research Articles on AKR1C4    1. Studies indicate that mutations in aldo-keto reductase family 1 (AKR1) enzymes AKR1C1 and AKR1C4 are responsible for sexual development dysgenesis and mutations in AKR1D1 are causative in bile-acid deficiency.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with AKR1C4 peptideDiseases associated with AKR1C4 peptide
 Products by Pathway  Pathway Diagram
 Benzo(a)pyrene Metabolism Pathway antibodies  Benzo(a)pyrene Metabolism Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Primary Bile Acid Biosynthesis Pathway antibodies  Primary Bile Acid Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >6 publications with AKR1C4 and Breast Neoplasms
 Adenocarcinoma Antibodies  >5 publications with AKR1C4 and Adenocarcinoma
 Mental Disorders Antibodies  >2 publications with AKR1C4 and Mental Disorders
 Mood Disorders Antibodies  >2 publications with AKR1C4 and Mood Disorders
 Hyperplasia Antibodies  >2 publications with AKR1C4 and Hyperplasia
 Bipolar Disorder Antibodies  >2 publications with AKR1C4 and Bipolar Disorder
 Atherosclerosis Antibodies  >1 publications with AKR1C4 and Atherosclerosis
 Vascular Diseases Antibodies  >1 publications with AKR1C4 and Vascular Diseases
 Inflammation Antibodies  >1 publications with AKR1C4 and Inflammation
 Neoplasms, Experimental Antibodies  >1 publications with AKR1C4 and Neoplasms, Experimental
Organs/Tissues associated with AKR1C4 peptide
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >31 publications with AKR1C4 and Liver
 Testis Antibodies  >7 publications with AKR1C4 and Testis
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