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| Product Name
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APBB1 / FE65, Peptide
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| Also Known As
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APBB1 / FE65 Immunizing Peptide
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| Product Synonym Names
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APBB1; FE65; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); MGC: 9072; RIR; adaptor protein FE65a2; amyloid beta A4 precursor protein-binding, family B, member 1; stat-like protein; APBB1 / FE65
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| Product Gene Name
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[Similar Products]
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| Product Synonym Gene Name
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FE65
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[Similar Products]
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| Antibody/Peptide Pairs
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APBB1 / FE65 peptide (MBS426988) is used for blocking the activity of APBB1/FE65 antibody (MBS420326)
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Sequence
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C-GSLKPKRL GAHTP
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| OMIM
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602709
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| Species Reactivity
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Human
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| Form/Format
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100ug of dried peptide
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| Preparation and Storage
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Shipped at ambient temperature, store at -20 degree C
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| ISO Certification
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Manufactured in an ISO 9001:2015 Certified Laboratory.
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| Other Notes
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Small volumes of APBB1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| NCBI/Uniprot data below describe general gene information for APBB1. It may not necessarily be applicable to this product. |
| NCBI GI #
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4502131
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| NCBI GeneID
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322
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| NCBI Accession #
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NP_001155.1
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[Other Products]
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| NCBI Related Accession #
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NP_663722.1
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_001164.4
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[Other Products]
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| UniProt Secondary Accession #
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Q7Z324; Q96A93; A1E379; A6NH82; A6NL69; B7Z1J5; B7Z1J6; B7Z2Y0; D3DQT2; V9GYK0; V9GYT4
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[Other Products]
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| UniProt Related Accession #
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O00213
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[Other Products]
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| Molecular Weight
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52,656 Da
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TOP
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| NCBI Official Full Name
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amyloid beta A4 protein-binding family B member 1 isoform a
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| NCBI Official Synonym Full Names
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amyloid beta precursor protein binding family B member 1
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| NCBI Official Symbol
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APBB1
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[Similar Products]
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| NCBI Official Synonym Symbols
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RIR; FE65; MGC:9072
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[Similar Products]
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| NCBI Protein Information
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amyloid beta A4 precursor protein-binding family B member 1
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| UniProt Protein Name
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Amyloid beta A4 precursor protein-binding family B member 1
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| UniProt Synonym Protein Names
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Protein Fe65
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| Protein Family
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Amyloid beta A4 precursor protein-binding family
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| UniProt Gene Name
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APBB1
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[Similar Products]
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| UniProt Synonym Gene Names
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FE65; RIR
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[Similar Products]
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| UniProt Entry Name
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APBB1_HUMAN
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| NCBI Summary for APBB1
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The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]
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| UniProt Comments for APBB1
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Fe65: adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on Y142 (H2AXpY142) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as TIP60, probably explains its trancription activation activity.
Protein type: Transcription regulation; Apoptosis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11p15
Cellular Component: cell soma; cytoplasm; dendritic spine; growth cone; lamellipodium; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic membrane; presynaptic membrane; protein complex; synapse
Molecular Function: beta-amyloid binding; chromatin binding; histone binding; protein binding; protein complex binding; tau protein binding; transcription factor binding
Biological Process: apoptosis; axonogenesis; cell cycle arrest; double-strand break repair; negative regulation of cell growth; negative regulation of thymidylate synthase biosynthetic process; positive regulation of apoptosis; positive regulation of DNA repair; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to iron ion; signal transduction; transcription, DNA-dependent
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TOP
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| Research Articles on APBB1
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1. Jagged1 is a novel binding partner of Fe65, and Fe65 may act as a novel effector of Jagged1 signaling.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Products associated with APBB1 peptide | Pathways associated with APBB1 peptide |
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| Diseases associated with APBB1 peptide | Organs/Tissues associated with APBB1 peptide |
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Peptide 
