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APH1A peptide

Scan QR to view Datasheet Catalog #    MBS426550 APH1A peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

APH1A, Peptide

 Also Known As   

APH1A Immunizing Peptide

 Product Synonym Names    APH1A; anterior pharynx defective 1 homolog A (C. elegans); 6530402N02Rik; APH-1A; CGI-78; anterior pharynx defective 1 homolog A
 Product Gene Name   

APH1A peptide

[Similar Products]
 Antibody/Peptide Pairs    APH1A peptide (MBS426550) is used for blocking the activity of APH1A antibody (MBS420705)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-HVTDRSDA RLQYG
 OMIM    607629
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 Species Reactivity    Human, Mouse, Rat, Dog, Pig, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of APH1A peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for APH1A. It may not necessarily be applicable to this product.
 NCBI GI #    117606362
 NCBI GeneID    51107
 NCBI Accession #    NP_001071096.1 [Other Products]
 NCBI Related Accession #    NP_057106.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001077628.2 [Other Products]
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 UniProt Secondary Accession #    Q5TB22; Q5TB23; Q969R6; Q9BVG0; Q9Y386; B4DQK0 [Other Products]
 UniProt Related Accession #    Q96BI3 [Other Products]
 Molecular Weight    20,977 Da
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 NCBI Official Full Name    gamma-secretase subunit APH-1A isoform 1
 NCBI Official Synonym Full Names    aph-1 homolog A, gamma-secretase subunit
 NCBI Official Symbol    APH1A [Similar Products]
 NCBI Official Synonym Symbols   
APH-1; APH-1A; CGI-78; 6530402N02Rik
[Similar Products]
 NCBI Protein Information    gamma-secretase subunit APH-1A
 UniProt Protein Name    Gamma-secretase subunit APH-1A
 UniProt Synonym Protein Names   
Aph-1alpha; Presenilin-stabilization factor
 Protein Family    Gamma-secretase
 UniProt Gene Name    APH1A [Similar Products]
 UniProt Synonym Gene Names    PSF; APH-1a [Similar Products]
 UniProt Entry Name    APH1A_HUMAN
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 NCBI Summary for APH1A    This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]
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 UniProt Comments for APH1A    APH1A: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Belongs to the APH-1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral; Endoplasmic reticulum; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p36.13-q31.3

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; integral to plasma membrane; membrane; plasma membrane

Molecular Function: endopeptidase activity; protein binding

Biological Process: amyloid precursor protein catabolic process; ephrin receptor signaling pathway; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; metanephros development; Notch receptor processing; Notch signaling pathway; positive regulation of apoptosis; positive regulation of catalytic activity; protein processing
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 Research Articles on APH1A    1. No statistically significant difference was detected either in APOE or APH-1a polymorphisms, not suggesting a strong susceptibility to the development of Alzheimer disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with APH1A peptidePathways associated with APH1A peptide
 Reference Product  PubMed Publications
 PSENEN peptide  >44 publications with APH1A and PSENEN
 PSEN1 peptide  >39 publications with APH1A and PSEN1
 BACE1 peptide  >37 publications with APH1A and BACE1
 APP peptide  >30 publications with APH1A and APP
 PSEN2 peptide  >11 publications with APH1A and PSEN2
 NOTCH1 peptide  >3 publications with APH1A and NOTCH1
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
Diseases associated with APH1A peptideOrgans/Tissues associated with APH1A peptide
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >29 publications with APH1A and Nervous System Diseases
 Vascular Diseases Antibodies  >3 publications with APH1A and Vascular Diseases
 Cardiovascular Diseases Antibodies  >3 publications with APH1A and Cardiovascular Diseases
 Neurologic Manifestations Antibodies  >1 publications with APH1A and Neurologic Manifestations
 Atherosclerosis Antibodies  >1 publications with APH1A and Atherosclerosis
 Weight Loss Antibodies  >1 publications with APH1A and Weight Loss
 Memory Disorders Antibodies  >1 publications with APH1A and Memory Disorders
 Learning Disorders Antibodies  >1 publications with APH1A and Learning Disorders
 Disease Models, Animal Antibodies  >1 publications with APH1A and Disease Models, Animal
 Necrosis Antibodies  >1 publications with APH1A and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >22 publications with APH1A and Brain
 Pharynx Antibodies  >18 publications with APH1A and Pharynx
 Vascular Antibodies  >4 publications with APH1A and Vascular
 Blood Antibodies  >3 publications with APH1A and Blood
 Embryonic Tissue Antibodies  >2 publications with APH1A and Embryonic Tissue
 Kidney Antibodies  >2 publications with APH1A and Kidney
 Nerve Antibodies  >2 publications with APH1A and Nerve
 Ovary Antibodies  >1 publications with APH1A and Ovary
 Connective Tissue Antibodies  >1 publications with APH1A and Connective Tissue
 Testis Antibodies  >1 publications with APH1A and Testis
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