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LDLRAP1 peptide :: ARH / LDL receptor adaptor Peptide

Scan QR to view Datasheet Catalog #    MBS425951 LDLRAP1 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ARH / LDL receptor adaptor (LDLRAP1), Peptide

 Also Known As   

ARH / LDL receptor adaptor Immunizing Peptide

 Product Synonym Names    ARH; LDL receptor adaptor protein; ARH2; FHCB1; FHCB2; MGC34705; DKFZp586D0624; low density lipoprotein receptor adaptor protein 1; RP11-70P17.2; autosomal recessive hypercholesterolemia protein; ARH / LDL receptor adaptor
 Product Gene Name   

LDLRAP1 peptide

[Similar Products]
 Product Synonym Gene Name    ARH; LDL [Similar Products]
 Antibody/Peptide Pairs    ARH / LDL receptor adaptor peptide (MBS425951) is used for blocking the activity of ARH/LDL receptor adaptor antibody (MBS420517)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    DALKSAGRAL IRS-C
 OMIM    603813
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 Species Reactivity    Human, Mouse, Rat, Dog, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of LDLRAP1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for LDLRAP1. It may not necessarily be applicable to this product.
 NCBI GI #    132626790
 NCBI GeneID    26119
 NCBI Accession #    NP_056442.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_015627.2 [Other Products]
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 UniProt Secondary Accession #    Q6TQS9; Q8N2Y0; Q9UFI9; A2BHI5 [Other Products]
 UniProt Related Accession #    Q5SW96 [Other Products]
 Molecular Weight    33,885 Da
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 NCBI Official Full Name    low density lipoprotein receptor adapter protein 1
 NCBI Official Synonym Full Names    low density lipoprotein receptor adaptor protein 1
 NCBI Official Symbol    LDLRAP1 [Similar Products]
 NCBI Official Synonym Symbols   
ARH; ARH1; ARH2; FHCB1; FHCB2
[Similar Products]
 NCBI Protein Information    low density lipoprotein receptor adapter protein 1
 UniProt Protein Name    Low density lipoprotein receptor adapter protein 1
 UniProt Synonym Protein Names   
Autosomal recessive hypercholesterolemia protein
 Protein Family    Low density lipoprotein receptor adapter protein
 UniProt Gene Name    LDLRAP1 [Similar Products]
 UniProt Synonym Gene Names    ARH [Similar Products]
 UniProt Entry Name    ARH_HUMAN
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 NCBI Summary for LDLRAP1    The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LDLRAP1    LDLRAP1: Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Defects in LDLRAP1 are the cause of autosomal recessive hypercholesterolemia (ARH). ARH is a disorder caused by defective internalization of LDL receptors (LDLR) in the liver. ARH has the clinical features of familial hypercholesterolemia (FH) homozygotes, including severely elevated plasma LDL cholesterol, tuberous and tendon xanthomata, and premature atherosclerosis. LDL receptor (LDLR) activity measured in skin fibroblasts is normal, as the LDL binding ability.

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: AP-1 adaptor complex; AP-2 adaptor complex; axon; basal plasma membrane; cytosol; early endosome; internal side of plasma membrane; neurofilament; recycling endosome

Molecular Function: beta-amyloid binding; clathrin binding; low-density lipoprotein receptor binding; phosphatidylinositol-4,5-bisphosphate binding; phosphotyrosine binding; protein binding; receptor signaling complex scaffold activity

Biological Process: amyloid precursor protein metabolic process; cholesterol homeostasis; cholesterol metabolic process; positive regulation of receptor-mediated endocytosis; positive regulation of signal transduction; receptor internalization; receptor-mediated endocytosis; regulation of protein binding; transport

Disease: Hypercholesterolemia, Autosomal Recessive
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 Research Articles on LDLRAP1    1. Numb specifically regulates NPC1L1-mediated cholesterol absorption both in human intestine and liver, distinct from ARH and Dab2, which selectively participate in LDLR-mediated LDL uptake.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to ARH / LDL receptor adaptor Immunizing Peptide
 Catalog #  Product Name
 MBS425951  ARH / LDL receptor adaptor Immunizing Peptide
Products associated with LDLRAP1 peptidePathways associated with LDLRAP1 peptide
 Reference Product  PubMed Publications
 LDLR peptide  >42 publications with LDLRAP1 and LDLR
 APOB peptide  >22 publications with LDLRAP1 and APOB
 DAB2 peptide  >9 publications with LDLRAP1 and DAB2
 LRP6 peptide  >4 publications with LDLRAP1 and LRP6
 APOE peptide  >4 publications with LDLRAP1 and APOE
 Products by Pathway  Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 LDL-mediated Lipid Transport Pathway antibodies  LDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
Diseases associated with LDLRAP1 peptideOrgans/Tissues associated with LDLRAP1 peptide
 Disease Name  Pubmed Publications
 Hypercholesterolemia, Autosomal Recessive Antibodies  >4 publications with LDLRAP1 and Hypercholesterolemia, Autosomal Recessive
 Carcinoma Antibodies  >3 publications with LDLRAP1 and Carcinoma
 Liver Diseases Antibodies  >3 publications with LDLRAP1 and Liver Diseases
 Hypertension Antibodies  >2 publications with LDLRAP1 and Hypertension
 Fatty Liver Antibodies  >1 publications with LDLRAP1 and Fatty Liver
 Cell Transformation, Neoplastic Antibodies  >1 publications with LDLRAP1 and Cell Transformation, Neoplastic
 Ovarian Neoplasms Antibodies  >1 publications with LDLRAP1 and Ovarian Neoplasms
 Disease Models, Animal Antibodies  >1 publications with LDLRAP1 and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with LDLRAP1 and Kidney Diseases
 Ovarian Diseases Antibodies  >1 publications with LDLRAP1 and Ovarian Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with LDLRAP1 and Blood
 Liver Antibodies  >21 publications with LDLRAP1 and Liver
 Heart Antibodies  >12 publications with LDLRAP1 and Heart
 Skin Antibodies  >6 publications with LDLRAP1 and Skin
 Nerve Antibodies  >4 publications with LDLRAP1 and Nerve
 Vascular Antibodies  >3 publications with LDLRAP1 and Vascular
 Kidney Antibodies  >2 publications with LDLRAP1 and Kidney
 Lung Antibodies  >2 publications with LDLRAP1 and Lung
 Brain Antibodies  >2 publications with LDLRAP1 and Brain
 Intestine Antibodies  >1 publications with LDLRAP1 and Intestine
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