NP_079547.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,565 Da
NCBI Official Full Name
actin-like 7b
NCBI Official Synonym Full Names
actin-like 7b
NCBI Official Synonym Symbols
NCBI Protein Information
actin-like protein 7B
UniProt Protein Name
Actin-like protein 7B
UniProt Synonym Protein Names
Actin-like-7-beta; Testis-specific actin-1; T-actin-1
UniProt Synonym Gene Names
UniProt Entry Name
ACL7B_MOUSE
UniProt Comments for Actl7b
ACTL7B: is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known. [provided by RefSeq, Jul 2008]
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Cellular Component: cytoplasm; cytoskeleton
Research Articles on Actl7b
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Organs/Tissues associated with Actl7b blocking peptide
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