NP_078827.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
adiponectin receptor protein 2
NCBI Official Synonym Full Names
adiponectin receptor 2
NCBI Protein Information
adiponectin receptor protein 2; progestin and adipoQ receptor family member II
UniProt Protein Name
Adiponectin receptor protein 2
UniProt Synonym Protein Names
Progestin and adipoQ receptor family member II
UniProt Synonym Gene Names
UniProt Entry Name
ADR2_HUMAN
NCBI Summary for ADIPOR2
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
UniProt Comments for ADIPOR2
Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin. Ref.5
Subunit structure: May form homomultimer and heteromultimers. Ref.5
Subcellular location: Membrane; Multi-pass membrane protein. Note: Localized to the cell membrane and intracellular organelles. Ref.5
Tissue specificity: Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung. Ref.1 Ref.5
Domain: The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.
Sequence similarities: Belongs to the ADIPOR family.
Sequence caution: The sequence BAB15062.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on ADIPOR2
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Products associated with ADIPOR2 peptide
Pathways associated with ADIPOR2 peptide
Diseases associated with ADIPOR2 peptide
Organs/Tissues associated with ADIPOR2 peptide
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