AAR37414.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
adrenergic receptor beta 3
NCBI Official Synonym Full Names
adrenoceptor beta 3
NCBI Official Synonym Symbols
NCBI Protein Information
beta-3 adrenergic receptor; beta-3 adrenoceptor; beta-3 adrenoreceptor; adrenergic, beta-3-, receptor
UniProt Protein Name
Beta-3 adrenergic receptor
UniProt Synonym Protein Names
Beta-3 adrenoreceptor
UniProt Synonym Gene Names
UniProt Entry Name
ADRB3_HUMAN
NCBI Summary for ADRB3
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]
UniProt Comments for ADRB3
ADRB3: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1
Chromosomal Location of Human Ortholog: 8p12
Cellular Component: integral to plasma membrane; plasma membrane; nucleus; receptor complex
Molecular Function: beta3-adrenergic receptor activity; protein binding; protein homodimerization activity; beta-3 adrenergic receptor binding; norepinephrine binding; epinephrine binding; beta-adrenergic receptor activity
Biological Process: arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; generation of precursor metabolites and energy; diet induced thermogenesis; negative regulation of multicellular organism growth; eating behavior; adenylate cyclase activation; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; response to antibiotic; G-protein signaling, coupled to cyclic nucleotide second messenger; positive regulation of MAPKKK cascade; heat generation; carbohydrate metabolic process; energy reserve metabolic process; brown fat cell differentiation; response to cold; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; aging
Disease: Obesity
Research Articles on ADRB3
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Products associated with ADRB3 peptide
Pathways associated with ADRB3 peptide
Diseases associated with ADRB3 peptide
Organs/Tissues associated with ADRB3 peptide
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