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AGT peptide :: Angiotensin I Peptide

Scan QR to view Datasheet Catalog #    MBS659852 AGT peptide
Unit / Price
5 mg  /  $350 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Angiotensin I (AGT), Peptide

★Popular Item★
 Also Known As   

Angiotensin I (human) (Biotin)

 Product Gene Name   

AGT peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (230838269..230850336, complement). Location: 1q42.2
 OMIM    106150
 3D Structure    ModBase 3D Structure for P01019
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 Host    Synthetic peptide
 Species Reactivity    Human
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 Purity/Purification    Highly Purified
95.52%
 Form/Format    Supplied as a lyophilized powder.
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 Sequence (linear)    Biotin-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu
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 Preparation and Storage    Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of AGT peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for AGT peptide    Molecular Biology; MB-Peptides
NCBI/Uniprot data below describe general gene information for AGT. It may not necessarily be applicable to this product.
 NCBI GI #    4557287
 NCBI GeneID    183
 NCBI Accession #    NP_000020.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000029.3 [Other Products]
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 UniProt Primary Accession #    P01019 [Other Products]
 UniProt Secondary Accession #    Q16358; Q16359; Q96F91 [Other Products]
 UniProt Related Accession #    P01019 [Other Products]
 Molecular Weight    1522.6D [Similar Products]
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 NCBI Official Full Name    angiotensinogen preproprotein
 NCBI Official Synonym Full Names    angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
 NCBI Official Symbol    AGT [Similar Products]
 NCBI Official Synonym Symbols   
ANHU; SERPINA8
[Similar Products]
 NCBI Protein Information    angiotensinogen; serpin A8; angiotensin I; angiotensin II; pre-angiotensinogen; alpha-1 antiproteinase, antitrypsin; serine (or cysteine) proteinase inhibitor
 UniProt Protein Name    Angiotensinogen
 UniProt Synonym Protein Names   
Serpin A8Cleaved into the following 8 chains:Angiotensin-1; Alternative name(s):; Angiotensin 1-10; Angiotensin I; Ang IAngiotensin-2; Alternative name(s):; Angiotensin 1-8; Angiotensin II; Ang IIAngiotensin-3; Alternative name(s):; Angiotensin 2-8; Angiotensin III; Ang III; Des-Asp[1]-angiotensin IIAngiotensin-4; Alternative name(s):; Angiotensin 3-8; Angiotensin IV
 Protein Family    Angiotensinogen
 UniProt Gene Name    AGT [Similar Products]
 UniProt Synonym Gene Names    SERPINA8; Ang I; Ang II; Ang III; Ang IV [Similar Products]
 UniProt Entry Name    ANGT_HUMAN
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 NCBI Summary for AGT    The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AGT    Function: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Ref.11 Ref.12 Ref.17Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Ref.11 Ref.12 Ref.17Angiotensin-3: stimulates aldosterone release. Ref.11 Ref.12 Ref.17Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1

By similarity. Has vasodilator and antidiuretic effects

By similarity. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets

By similarity. Ref.11 Ref.12 Ref.17

Subunit structure: During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg. Ref.8 Ref.23

Subcellular location: Secreted.

Tissue specificity: Expressed by the liver and secreted in plasma.

Post-translational modification: Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Ref.13 Ref.14The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.

Involvement in disease: Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal with no identifiable cause.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.29

Sequence similarities: Belongs to the serpin family.

Caution: It is uncertain whether Met-1 or Met-10 is the initiator.
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 Research Articles on AGT    1. This report is the first one in the literature showing association of g.15241A>G polymorphism with a clinical condition, in this case, hypertension.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AGT peptidePathways associated with AGT peptide
 Reference Product  PubMed Publications
 ACE peptide  >425 publications with AGT and ACE
 AGTR1 peptide  >99 publications with AGT and AGTR1
 AGTR2 peptide  >53 publications with AGT and AGTR2
 REN peptide  >53 publications with AGT and REN
 ACE2 peptide  >26 publications with AGT and ACE2
 TGFB1 peptide  >23 publications with AGT and TGFB1
 IL6 peptide  >5 publications with AGT and IL6
 INS peptide  >5 publications with AGT and INS
 KNG1 peptide  >1 publications with AGT and KNG1
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
Diseases associated with AGT peptideOrgans/Tissues associated with AGT peptide
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >551 publications with AGT and Cardiovascular Diseases
 Hypertension Antibodies  >517 publications with AGT and Hypertension
 Kidney Diseases Antibodies  >251 publications with AGT and Kidney Diseases
 Heart Diseases Antibodies  >169 publications with AGT and Heart Diseases
 Hypertension, Renal Antibodies  >117 publications with AGT and Hypertension, Renal
 Myocardial Ischemia Antibodies  >99 publications with AGT and Myocardial Ischemia
 Hypertrophy Antibodies  >76 publications with AGT and Hypertrophy
 Atherosclerosis Antibodies  >68 publications with AGT and Atherosclerosis
 Myocardial Infarction Antibodies  >61 publications with AGT and Myocardial Infarction
 Proteinuria Antibodies  >58 publications with AGT and Proteinuria
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >674 publications with AGT and Blood
 Kidney Antibodies  >288 publications with AGT and Kidney
 Liver Antibodies  >280 publications with AGT and Liver
 Heart Antibodies  >153 publications with AGT and Heart
 Brain Antibodies  >117 publications with AGT and Brain
 Lung Antibodies  >72 publications with AGT and Lung
 Muscle Antibodies  >66 publications with AGT and Muscle
 Bone Antibodies  >62 publications with AGT and Bone
 Connective Tissue Antibodies  >50 publications with AGT and Connective Tissue
 Ovary Antibodies  >43 publications with AGT and Ovary
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