NP_000342.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,492 Da
NCBI Official Full Name
steryl-sulfatase isoform 1
NCBI Official Synonym Full Names
steroid sulfatase (microsomal), isozyme S
NCBI Official Synonym Symbols
ES; ASC; XLI; ARSC; SSDD; ARSC1 [Similar Products]
NCBI Protein Information
steryl-sulfatase
UniProt Protein Name
Steryl-sulfatase
UniProt Synonym Protein Names
Arylsulfatase C; ASC; Steroid sulfatase; Steryl-sulfate sulfohydrolase
UniProt Synonym Gene Names
UniProt Entry Name
STS_HUMAN
NCBI Summary for STS
This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]
UniProt Comments for STS
STS: Conversion of sulfated steroid precursors to estrogens during pregnancy. Defects in STS are the cause of ichthyosis X-linked (IXL). Ichthyosis X-linked is a keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks. Belongs to the sulfatase family.
Protein type: EC 3.1.6.2; Hydrolase; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: Xp22.32
Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endosome; Golgi apparatus; intracellular membrane-bound organelle; lysosome; membrane; plasma membrane
Molecular Function: steryl-sulfatase activity; sulfuric ester hydrolase activity
Biological Process: epidermis development; glycosphingolipid metabolic process; post-translational protein modification; steroid catabolic process
Disease: Ichthyosis, X-linked
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Products associated with STS blocking peptide
Pathways associated with STS blocking peptide
Diseases associated with STS blocking peptide
Organs/Tissues associated with STS blocking peptide
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