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ACTL6A peptide :: BAF53A and BAF53B Peptide

Scan QR to view Datasheet Catalog #    MBS425661 ACTL6A peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BAF53A and BAF53B (ACTL6A), Peptide

 Also Known As   

BAF53A and BAF53B Immunizing Peptide

 Product Synonym Names    BAF53A; BAF53B; ACTL6; BAF53a; BAF53b; actin-like 6A; actin-like 6B; hArpN alpha; actin-related protein; ACTL6A; ACTL6B; 53 kDa BRG1-associated factor B; ARPN-BETA; MGC5382 Arp4; INO80K; BAF complex 53 kDa subunit; BAF53; BRG1-associated factor; INO80 com; BAF53A and BAF53B
 Product Gene Name   

ACTL6A peptide

[Similar Products]
 Product Synonym Gene Name    BAF53A; BAF53B [Similar Products]
 Antibody/Peptide Pairs    BAF53A and BAF53B peptide (MBS425661) is used for blocking the activity of BAF53A and BAF53B antibody (MBS420286)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604958
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 Species Reactivity    Human, Mouse, Rat, Dog, Pig, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of ACTL6A peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ACTL6A. It may not necessarily be applicable to this product.
 NCBI GI #    4757718
 NCBI GeneID    86
 NCBI Accession #    NP_004292.1 [Other Products]
 NCBI Related Accession #    NP_817126.1; NP_057272.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004301.4 [Other Products]
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 UniProt Secondary Accession #    Q8TAE5; Q9BVS8; Q9H0W6; B3KMN1; D3DNR9 [Other Products]
 UniProt Related Accession #    O96019 [Other Products]
 Molecular Weight    43,236 Da
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 NCBI Official Full Name    actin-like protein 6A isoform 1
 NCBI Official Synonym Full Names    actin like 6A
 NCBI Official Symbol    ACTL6A [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    actin-like protein 6A
 UniProt Protein Name    Actin-like protein 6A
 UniProt Synonym Protein Names   
53 kDa BRG1-associated factor A; Actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K
 Protein Family    Actin-like protein
 UniProt Gene Name    ACTL6A [Similar Products]
 UniProt Synonym Gene Names    BAF53; BAF53A; INO80K; BAF53A [Similar Products]
 UniProt Entry Name    ACL6A_HUMAN
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 NCBI Summary for ACTL6A    This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACTL6A    BAF53A: an actin-related protein involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for maximal ATPase activity of the helicase SMARCA4 and for association of the SMARCA4 containing remodelling complex BAF with chromatin/nuclear matrix. A component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of specific genes. Two alternatively spliced human isoforms have been described.

Chromosomal Location of Human Ortholog: 3q26.33

Cellular Component: NuA4 histone acetyltransferase complex; nuclear chromatin; nucleoplasm; nucleus; plasma membrane; protein complex; SWI/SNF complex

Molecular Function: chromatin binding; nucleosomal DNA binding; protein binding; transcription coactivator activity

Biological Process: ATP-dependent chromatin remodeling; chromatin remodeling; DNA recombination; DNA repair; regulation of growth; regulation of transcription from RNA polymerase II promoter; signal transduction; spinal cord development; transcription, DNA-dependent
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 Research Articles on ACTL6A    1. These results indicate that failure to downregulate the BAF53a subunit may contribute to the pathogenesis of rhabdomyosarcoma, and suggest that BAF53a may represent a novel therapeutic target for this tumor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ACTL6A peptideDiseases associated with ACTL6A peptide
 Products by Pathway  Pathway Diagram
 C-MYC Pathway antibodies  C-MYC Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 DNA Damage Recognition In GG-NER Pathway antibodies  DNA Damage Recognition In GG-NER Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Gastric Cancer Network 1 Pathway antibodies  Gastric Cancer Network 1 Pathway Diagram
 Global Genome Nucleotide Excision Repair (GG-NER) Pathway antibodies  Global Genome Nucleotide Excision Repair (GG-NER) Pathway Diagram
 HATs Acetylate Histones Pathway antibodies  HATs Acetylate Histones Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with ACTL6A and Nervous System Diseases
 Memory Disorders Antibodies  >3 publications with ACTL6A and Memory Disorders
 Neurobehavioral Manifestations Antibodies  >2 publications with ACTL6A and Neurobehavioral Manifestations
 Disease Models, Animal Antibodies  >2 publications with ACTL6A and Disease Models, Animal
 Neurologic Manifestations Antibodies  >2 publications with ACTL6A and Neurologic Manifestations
 Carcinoma Antibodies  >2 publications with ACTL6A and Carcinoma
 Abnormalities, Multiple Antibodies  >1 publications with ACTL6A and Abnormalities, Multiple
 Kidney Diseases Antibodies  >1 publications with ACTL6A and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with ACTL6A and Carcinoma, Hepatocellular
 Anemia Antibodies  >1 publications with ACTL6A and Anemia
Organs/Tissues associated with ACTL6A peptide
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with ACTL6A and Brain
 Muscle Antibodies  >2 publications with ACTL6A and Muscle
 Kidney Antibodies  >2 publications with ACTL6A and Kidney
 Liver Antibodies  >2 publications with ACTL6A and Liver
 Blood Antibodies  >2 publications with ACTL6A and Blood
 Nerve Antibodies  >1 publications with ACTL6A and Nerve
 Bone Marrow Antibodies  >1 publications with ACTL6A and Bone Marrow
 Heart Antibodies  >1 publications with ACTL6A and Heart
 Embryonic Tissue Antibodies  >1 publications with ACTL6A and Embryonic Tissue
 Bone Antibodies  >1 publications with ACTL6A and Bone
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