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SMARCE1 peptide :: BAF57 / SMARCE1 Peptide

Scan QR to view Datasheet Catalog #    MBS425198 SMARCE1 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BAF57 / SMARCE1, Peptide

 Also Known As   

BAF57 / SMARCE1 Immunizing Peptide

 Product Synonym Names    SMARCE1; BAF57; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1; mammalian chromatin remodeling complex BRG1-associated factor 57; BAF57; SWI/SNF-related matrix-associated actin-dependent regulator of chro; BAF57 / SMARCE1
 Product Gene Name   

SMARCE1 peptide

[Similar Products]
 Product Synonym Gene Name    BAF57 [Similar Products]
 Antibody/Peptide Pairs    BAF57 / SMARCE1 peptide (MBS425198) is used for blocking the activity of BAF57/SMARCE1 antibody (MBS421366)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-PPTDPIPE DEKKE
 OMIM    603111
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 Species Reactivity    Human, Mouse
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of SMARCE1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for SMARCE1. It may not necessarily be applicable to this product.
 NCBI GI #    21264355
 NCBI GeneID    6605
 NCBI Accession #    NP_003070.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_003079.4 [Other Products]
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 UniProt Secondary Accession #    O43539; B3KMC1; B4DFR4; C0IMW4; C0IMW5; C0IMW7; H7C3F6 [Other Products]
 UniProt Related Accession #    Q969G3 [Other Products]
 Molecular Weight    34,390 Da
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 NCBI Official Full Name    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
 NCBI Official Synonym Full Names    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
 NCBI Official Symbol    SMARCE1 [Similar Products]
 NCBI Official Synonym Symbols   
CSS5; BAF57
[Similar Products]
 NCBI Protein Information    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
 UniProt Protein Name    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
 UniProt Synonym Protein Names   
BRG1-associated factor 57; BAF57
 Protein Family    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily
 UniProt Gene Name    SMARCE1 [Similar Products]
 UniProt Synonym Gene Names    BAF57; BAF57 [Similar Products]
 UniProt Entry Name    SMCE1_HUMAN
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 NCBI Summary for SMARCE1    The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SMARCE1    SMARCE1: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Defects in SMARCE1 may be a cause of Coffin-Siris syndrome, a highly variable disease characterized by mental retardation associated with a broad spectrum of different clinical features. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: nuclear chromatin; nuclear chromosome; nucleoplasm; nucleus; protein complex; SWI/SNF complex; transcriptional repressor complex

Molecular Function: chromatin binding; ligand-dependent nuclear receptor binding; N-acetyltransferase activity; nucleosomal DNA binding; protein binding; protein N-terminus binding; RNA binding; transcription coactivator activity

Biological Process: ATP-dependent chromatin remodeling; chromatin remodeling; negative regulation of transcription, DNA-dependent; neurogenesis; nucleosome disassembly; regulation of transcription from RNA polymerase II promoter

Disease: Meningioma, Familial, Susceptibility To
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 Research Articles on SMARCE1    1. Addition of the EGFR inhibitor gefitinib restores the sensitivity of SMARCE1-knockdown cells to MET and ALK inhibitors in NSCLCs. Our findings link SMARCE1 to EGFR oncogenic signaling and suggest targeted treatment options for SMARCE1-deficient tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SMARCE1 peptideDiseases associated with SMARCE1 peptide
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 RMTs Methylate Histone Arginines Pathway antibodies  RMTs Methylate Histone Arginines Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Coffin-Siris syndrome Antibodies  >10 publications with SMARCE1 and Coffin-Siris syndrome
 Mental Disorders Antibodies  >9 publications with SMARCE1 and Mental Disorders
 Neurobehavioral Manifestations Antibodies  >8 publications with SMARCE1 and Neurobehavioral Manifestations
 Neoplasm Metastasis Antibodies  >3 publications with SMARCE1 and Neoplasm Metastasis
 Genital Diseases, Male Antibodies  >3 publications with SMARCE1 and Genital Diseases, Male
 Immune System Diseases Antibodies  >1 publications with SMARCE1 and Immune System Diseases
 Lung Diseases Antibodies  >1 publications with SMARCE1 and Lung Diseases
 Hepatitis Antibodies  >1 publications with SMARCE1 and Hepatitis
 Inflammation Antibodies  >1 publications with SMARCE1 and Inflammation
 Weight Loss Antibodies  >1 publications with SMARCE1 and Weight Loss
Organs/Tissues associated with SMARCE1 peptide
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with SMARCE1 and Brain
 Testis Antibodies  >6 publications with SMARCE1 and Testis
 Prostate Antibodies  >4 publications with SMARCE1 and Prostate
 Vascular Antibodies  >3 publications with SMARCE1 and Vascular
 Mammary Gland Antibodies  >3 publications with SMARCE1 and Mammary Gland
 Blood Antibodies  >3 publications with SMARCE1 and Blood
 Muscle Antibodies  >3 publications with SMARCE1 and Muscle
 Skin Antibodies  >2 publications with SMARCE1 and Skin
 Nerve Antibodies  >2 publications with SMARCE1 and Nerve
 Heart Antibodies  >2 publications with SMARCE1 and Heart
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