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BCL2 peptide

Scan QR to view Datasheet Catalog #    MBS426740 BCL2 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BCL2, Peptide

 Also Known As   

BCL2 Immunizing Peptide

 Product Synonym Names    BCL2; Bcl-2; B-cell CLL/lymphoma 2; B-cell lymphoma protein 2; OTTHUMP00000163680
 Product Gene Name   

BCL2 peptide

[Similar Products]
 Antibody/Peptide Pairs    BCL2 peptide (MBS426740) is used for blocking the activity of BCL2 antibody (MBS421088)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    AGRTGYDNRE IVMKYC
 OMIM    151430
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 Species Reactivity    Human, Mouse, Rat, Dog
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of BCL2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for BCL2. It may not necessarily be applicable to this product.
 NCBI GI #    72198189
 NCBI GeneID    596
 NCBI Accession #    NP_000624.2 [Other Products]
 NCBI Related Accession #    NP_000648.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000633.2 [Other Products]
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 UniProt Secondary Accession #    P10416; Q13842; Q16197; C9JHD5 [Other Products]
 UniProt Related Accession #    P10415 [Other Products]
 Molecular Weight    22,337 Da
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 NCBI Official Full Name    apoptosis regulator Bcl-2 alpha isoform
 NCBI Official Synonym Full Names    B-cell CLL/lymphoma 2
 NCBI Official Symbol    BCL2 [Similar Products]
 NCBI Official Synonym Symbols   
Bcl-2; PPP1R50
[Similar Products]
 NCBI Protein Information    apoptosis regulator Bcl-2
 UniProt Protein Name    Apoptosis regulator Bcl-2
 Protein Family    Bcl2-associated agonist of cell death
 UniProt Gene Name    BCL2 [Similar Products]
 UniProt Entry Name    BCL2_HUMAN
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 NCBI Summary for BCL2    This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
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 UniProt Comments for BCL2    Bcl-2: a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions.

Protein type: Membrane protein, integral; Apoptosis; Autophagy; Oncoprotein

Chromosomal Location of Human Ortholog: 18q21.3

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial outer membrane; mitochondrion; myelin sheath; nuclear membrane; nucleus; pore complex

Molecular Function: BH3 domain binding; channel activity; channel inhibitor activity; identical protein binding; protease binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein phosphatase 2A binding; sequence-specific DNA binding; transcription factor binding; ubiquitin protein ligase binding

Biological Process: actin filament organization; apoptosis; axon regeneration; axonogenesis; B cell homeostasis; B cell lineage commitment; B cell proliferation; B cell receptor signaling pathway; behavioral fear response; CD8-positive, alpha-beta T cell lineage commitment; cell aging; cell growth; cellular response to glucose starvation; cochlear nucleus development; defense response to virus; digestive tract morphogenesis; DNA damage response, signal transduction resulting in induction of apoptosis; ear development; endoplasmic reticulum calcium ion homeostasis; female pregnancy; focal adhesion formation; gland morphogenesis; glomerulus development; hair follicle morphogenesis; homeostasis of number of cells within a tissue; humoral immune response; induction of apoptosis by oxidative stress; induction of apoptosis via death domain receptors; lymphoid progenitor cell differentiation; male gonad development; melanin metabolic process; melanocyte differentiation; mesenchymal cell development; metanephros development; negative regulation of apoptosis; negative regulation of autophagy; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cellular pH reduction; negative regulation of mitochondrial depolarization; negative regulation of myeloid cell apoptosis; negative regulation of neuron apoptosis; negative regulation of ossification; negative regulation of osteoblast proliferation; negative regulation of retinal cell programmed cell death; neuron apoptosis; oocyte development; organ growth; ossification; ovarian follicle development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pigment granule organization and biogenesis; positive regulation of B cell proliferation; positive regulation of catalytic activity; positive regulation of cell growth; positive regulation of melanocyte differentiation; positive regulation of multicellular organism growth; positive regulation of neuron maturation; positive regulation of peptidyl-serine phosphorylation; positive regulation of skeletal muscle fiber development; positive regulation of smooth muscle cell migration; post-embryonic development; protein amino acid dephosphorylation; protein polyubiquitination; regulation of calcium ion transport; regulation of cell-matrix adhesion; regulation of gene expression; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; regulation of nitrogen utilization; regulation of protein heterodimerization activity; regulation of protein homodimerization activity; regulation of protein stability; regulation of transmembrane transporter activity; regulation of viral genome replication; release of cytochrome c from mitochondria; renal system process; response to cytokine stimulus; response to DNA damage stimulus; response to drug; response to gamma radiation; response to glucocorticoid stimulus; response to hydrogen peroxide; response to iron ion; response to nicotine; response to radiation; response to toxin; response to UV-B; spleen development; T cell differentiation in the thymus; T cell homeostasis; thymus development; transmembrane transport; ureteric bud branching
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 Research Articles on BCL2    1. Suggest that combination of Bcl-2 and Ki67 to detect gastric cancer is more effective.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BCL2 peptidePathways associated with BCL2 peptide
 Reference Product  PubMed Publications
 BAX peptide  >2161 publications with BCL2 and BAX
 BAD peptide  >268 publications with BCL2 and BAD
 TP53 peptide  >227 publications with BCL2 and TP53
 BID peptide  >141 publications with BCL2 and BID
 BCL2L11 peptide  >115 publications with BCL2 and BCL2L11
 BAK1 peptide  >94 publications with BCL2 and BAK1
 BECN1 peptide  >87 publications with BCL2 and BECN1
 BIK peptide  >42 publications with BCL2 and BIK
 MAPK8 peptide  >18 publications with BCL2 and MAPK8
 FKBP8 peptide  >1 publications with BCL2 and FKBP8
 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Diseases associated with BCL2 peptideOrgans/Tissues associated with BCL2 peptide
 Disease Name  Pubmed Publications
 Lymphoma, Non-Hodgkin Antibodies  >879 publications with BCL2 and Lymphoma, Non-Hodgkin
 Carcinoma Antibodies  >843 publications with BCL2 and Carcinoma
 Lymphoma, Large B-Cell, Diffuse Antibodies  >465 publications with BCL2 and Lymphoma, Large B-Cell, Diffuse
 Necrosis Antibodies  >443 publications with BCL2 and Necrosis
 Lymphoma, Follicular Antibodies  >435 publications with BCL2 and Lymphoma, Follicular
 Breast Neoplasms Antibodies  >378 publications with BCL2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >344 publications with BCL2 and Adenocarcinoma
 Disease Progression Antibodies  >320 publications with BCL2 and Disease Progression
 Head and Neck Neoplasms Antibodies  >182 publications with BCL2 and Head and Neck Neoplasms
 Intestinal Neoplasms Antibodies  >179 publications with BCL2 and Intestinal Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1197 publications with BCL2 and Blood
 Brain Antibodies  >463 publications with BCL2 and Brain
 Bone Antibodies  >417 publications with BCL2 and Bone
 Lung Antibodies  >353 publications with BCL2 and Lung
 Muscle Antibodies  >349 publications with BCL2 and Muscle
 Lymph Node Antibodies  >309 publications with BCL2 and Lymph Node
 Bone Marrow Antibodies  >293 publications with BCL2 and Bone Marrow
 Vascular Antibodies  >283 publications with BCL2 and Vascular
 Heart Antibodies  >276 publications with BCL2 and Heart
 Lymph Antibodies  >250 publications with BCL2 and Lymph
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