NP_004040.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,746 Da
NCBI Official Full Name
bcl-2-related protein A1 isoform 1
NCBI Official Synonym Full Names
BCL2 related protein A1
NCBI Official Synonym Symbols
GRS; ACC1; ACC2; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5 [Similar Products]
NCBI Protein Information
bcl-2-related protein A1
UniProt Protein Name
Bcl-2-related protein A1
UniProt Synonym Protein Names
Bcl-2-like protein 5; Bcl2-L-5; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS
UniProt Synonym Gene Names
UniProt Entry Name
B2LA1_HUMAN
NCBI Summary for BCL2A1
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for BCL2A1
BCL2A1: Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. Interacts directly with BAK1, BID, BMF and BBC3. Interacts directly with BCL2L11/BIM. Interacts with BAX isoform Sigma. Interacts directly with PMAIP1. By phorbol ester and inflammatory cytokines, such as TNF or IL1B/interleukin-1 beta, but not by growth factors. Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies. Belongs to the Bcl-2 family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 15q24.3
Cellular Component: mitochondrial outer membrane
Molecular Function: channel activity; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; mitochondrial fusion; negative regulation of apoptosis; positive regulation of apoptosis; release of cytochrome c from mitochondria; transmembrane transport
Research Articles on BCL2A1
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Pathways associated with BCL2A1 blocking peptide
Diseases associated with BCL2A1 blocking peptide
Organs/Tissues associated with BCL2A1 blocking peptide
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