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Bad peptide

Scan QR to view Datasheet Catalog #    MBS443003 Bad peptide
Unit / Price
0.1 mg  /  $125 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bad, Peptide

 Also Known As   

Bad (A17) Blocking Peptide

 Product Gene Name   

Bad peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603167
 3D Structure    ModBase 3D Structure for Q6FH21
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 Concentration    0.100 mg/0.5 ml (lot specific)
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 Preparation and Storage    Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
 Other Notes    Small volumes of Bad peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for Bad peptide    Controls
NCBI/Uniprot data below describe general gene information for Bad. It may not necessarily be applicable to this product.
 NCBI GI #    10835069
 NCBI GeneID    572
 NCBI Accession #    NP_004313.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004322.3 [Other Products]
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 UniProt Primary Accession #    Q6FH21 [Other Products]
 UniProt Secondary Accession #    O14803; Q6FH21 [Other Products]
 UniProt Related Accession #    Q92934 [Other Products]
 Molecular Weight    18,392 Da
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 NCBI Official Full Name    bcl2 antagonist of cell death
 NCBI Official Synonym Full Names    BCL2-associated agonist of cell death
 NCBI Official Symbol    BAD [Similar Products]
 NCBI Official Synonym Symbols   
BBC2; BCL2L8
[Similar Products]
 NCBI Protein Information    bcl2-associated agonist of cell death; BCL-X/BCL-2 binding protein; BCL2-antagonist of cell death protein; BCL2-binding component 6; BCL2-binding protein; bcl-2-binding component 6; bcl-2-like protein 8; bcl-XL/Bcl-2-associated death promoter; bcl2 antagonist of cell death; bcl2-L-8
 UniProt Protein Name    Bcl2-associated agonist of cell death
 UniProt Synonym Protein Names   
Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death
 Protein Family    Bcl2-associated agonist of cell death
 UniProt Gene Name    BAD [Similar Products]
 UniProt Synonym Gene Names    BBC6; BCL2L8; BAD; Bcl2-L-8 [Similar Products]
 UniProt Entry Name    BAD_HUMAN
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 NCBI Summary for Bad    The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Bad    BAD: a proapoptotic member of the Bcl-2 family. Displaces Bax from binding to Bcl-2 and Bcl-xL, resulting in cell death. Survival factors such as IL-3 can inhibit the apoptotic activity of Bad inducing the phosphorylation of Bad by Akt and p90RSK. 14-3-3 proteins bind phosphorylated Bad, inhibiting its binding to Bcl-2 and Bcl-xL. Phosphorylation by mitochondria-anchored PKA in the BH3 domain can block the dimerization of Bad and Bcl-xL.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: mitochondrial outer membrane; mitochondrion; cytosol

Molecular Function: protein kinase B binding; protein binding; protein heterodimerization activity; phospholipid binding; caspase activator activity; lipid binding; protein kinase binding; protein phosphatase 2B binding

Biological Process: response to oleate; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of proteolysis; apoptosis; response to glucocorticoid stimulus; positive regulation of caspase activity; cellular process regulating host cell cycle in response to virus; glucose homeostasis; response to estradiol stimulus; positive regulation of apoptosis by virus; response to glucose stimulus; pore complex biogenesis; positive regulation of autophagy; positive regulation of glucokinase activity; caspase activation; response to drug; epidermal growth factor receptor signaling pathway; release of cytochrome c from mitochondria; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; cytokine and chemokine mediated signaling pathway; suppression by virus of host apoptosis; positive regulation of insulin secretion; ADP metabolic process; response to testosterone stimulus; response to amino acid stimulus; ATP metabolic process; glucose catabolic process; response to ethanol; induction of apoptosis via death domain receptors; response to hydrogen peroxide; DNA damage response, signal transduction resulting in induction of apoptosis; positive regulation of T cell differentiation; innate immune response; positive regulation of B cell differentiation; regulation of mitochondrial membrane permeability; response to progesterone stimulus; response to calcium ion; positive regulation of epithelial cell proliferation
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 Research Articles on Bad    1. Results suggest that regulation of the proapoptotic activity of BAD plays a key role in the pathogenic mechanisms resulting in primary pigmented nodular adrenocortical disease tumor formation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Bad peptidePathways associated with Bad peptide
 Reference Product  PubMed Publications
 BCL2L1 peptide  >550 publications with Bad and BCL2L1
 AKT1 peptide  >253 publications with Bad and AKT1
 BCL2 peptide  >229 publications with Bad and BCL2
 MAPK8 peptide  >11 publications with Bad and MAPK8
 RAF1 peptide  >6 publications with Bad and RAF1
 SFN peptide  >3 publications with Bad and SFN
 SNCA peptide  >3 publications with Bad and SNCA
 PRKACA peptide  >1 publications with Bad and PRKACA
 YWHAQ peptide  >1 publications with Bad and YWHAQ
 YWHAZ peptide  >1 publications with Bad and YWHAZ
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
Diseases associated with Bad peptideOrgans/Tissues associated with Bad peptide
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >4871 publications with Bad and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >3447 publications with Bad and Nervous System Diseases
 Heart Diseases Antibodies  >2876 publications with Bad and Heart Diseases
 Pain Antibodies  >1963 publications with Bad and Pain
 Brain Diseases Antibodies  >1669 publications with Bad and Brain Diseases
 Inflammation Antibodies  >894 publications with Bad and Inflammation
 Hypertension Antibodies  >883 publications with Bad and Hypertension
 Necrosis Antibodies  >745 publications with Bad and Necrosis
 Liver Diseases Antibodies  >667 publications with Bad and Liver Diseases
 Kidney Diseases Antibodies  >650 publications with Bad and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >3666 publications with Bad and Heart
 Brain Antibodies  >1890 publications with Bad and Brain
 Bone Antibodies  >1888 publications with Bad and Bone
 Lung Antibodies  >1304 publications with Bad and Lung
 Muscle Antibodies  >1268 publications with Bad and Muscle
 Liver Antibodies  >1008 publications with Bad and Liver
 Kidney Antibodies  >853 publications with Bad and Kidney
 Skin Antibodies  >837 publications with Bad and Skin
 Nerve Antibodies  >631 publications with Bad and Nerve
 Eye Antibodies  >512 publications with Bad and Eye
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