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Bax peptide

Scan QR to view Datasheet Catalog #    MBS443005 Bax peptide
Unit / Price
0.1 mg  /  $125 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bax, Peptide

 Also Known As   

Bax (A20) Blocking Peptide

 Product Gene Name   

Bax peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q63690
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 Concentration    0.100 mg/0.5 ml (lot specific)
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 Preparation and Storage    Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
 Other Notes    Small volumes of Bax peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for Bax peptide    Controls
NCBI/Uniprot data below describe general gene information for Bax. It may not necessarily be applicable to this product.
 NCBI GI #    975870
 NCBI GeneID    24887
 NCBI Accession #    AAA75200.1 [Other Products]
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 UniProt Primary Accession #    Q63690 [Other Products]
 UniProt Secondary Accession #    Q62995; Q64383 [Other Products]
 UniProt Related Accession #    Q63690 [Other Products]
 Molecular Weight    – Da
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 NCBI Official Full Name    bax, partial
 NCBI Official Synonym Full Names    Bcl2-associated X protein
 NCBI Official Symbol    Bax [Similar Products]
 NCBI Protein Information    apoptosis regulator BAX
 UniProt Protein Name    Apoptosis regulator BAX
 Protein Family    Bax inhibitor
 UniProt Gene Name    Bax [Similar Products]
 UniProt Entry Name    BAX_RAT
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 NCBI Summary for Bax    Bcl2-related gene; involved in the regulation of apoptotic cell death [RGD, Feb 2006]
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 UniProt Comments for Bax    BAX: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. Homodimer. Forms higher oligomers under stress conditions. Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells. Interacts with FAIM2/LFG2. Interacts with human cytomegalovirus/HHV-5 protein vMIA/UL37. Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro- myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T- cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines. Belongs to the Bcl-2 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Mitochondrial; Apoptosis; Tumor suppressor

Cellular Component: mitochondrial permeability transition pore complex; endoplasmic reticulum membrane; mitochondrion; cell; endoplasmic reticulum; nuclear envelope; cytosol; pore complex; mitochondrial outer membrane; membrane; cytoplasm; mitochondrial membrane; intracellular; nucleus

Molecular Function: BH domain binding; identical protein binding; protein binding; protein homodimerization activity; channel activity; protein heterodimerization activity; chaperone binding; heat shock protein binding; BH3 domain binding; protein complex binding; lipid binding

Biological Process: hypothalamus development; regulation of cell cycle; positive regulation of apoptosis; response to toxin; myeloid cell homeostasis; germ cell programmed cell death; homeostasis of number of cells; B cell apoptosis; post-embryonic development; germ cell development; regulation of mammary gland epithelial cell proliferation; spermatid differentiation; development of secondary sexual characteristics; regulation of mitochondrial membrane potential; protein insertion into mitochondrial membrane during induction of apoptosis; regulation of neuron apoptosis; establishment and/or maintenance of transmembrane electrochemical gradient; negative regulation of neuron apoptosis; kidney development; negative regulation of protein binding; response to corticosterone stimulus; inner mitochondrial membrane organization and biogenesis; response to drug; nervous system development; release of cytochrome c from mitochondria; positive regulation of B cell apoptosis; outer mitochondrial membrane organization and biogenesis; regulation of protein homodimerization activity; cellular respiration; vagina development; protein oligomerization; fertilization; DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; negative regulation of fibroblast proliferation; retina development in camera-type eye; reduction of endoplasmic reticulum calcium ion concentration; glycosphingolipid metabolic process; response to ionizing radiation; mitochondrial fragmentation during apoptosis; cerebral cortex development; regulation of nitrogen utilization; post-embryonic camera-type eye morphogenesis; positive regulation of pigmentation; regulation of protein heterodimerization activity; apoptosis; T cell homeostatic proliferation; negative regulation of peptidyl-serine phosphorylation; positive regulation of apoptosis involved in mammary gland involution; neuron migration; regulation of caspase activity; release of matrix enzymes from mitochondria; response to salt stress; positive regulation of protein oligomerization; negative regulation of cell proliferation; apoptotic mitochondrial changes; B cell homeostatic proliferation; B cell homeostasis; ovarian follicle development; positive regulation of neuron apoptosis; response to wounding; response to gamma radiation; response to axon injury; B cell negative selection; protein homooligomerization; leukocyte homeostasis; caspase activation; mitochondrial fusion; transformed cell apoptosis; male gonad development; Sertoli cell proliferation; response to cocaine; limb morphogenesis; odontogenesis of dentine-containing teeth; cell proliferation; neuron apoptosis; response to copper ion; homeostasis of number of cells within a tissue; retinal cell programmed cell death; spermatogenesis; blood vessel remodeling; brain development; positive regulation of release of sequestered calcium ion into cytosol; caspase activation via cytochrome c; sex differentiation; response to DNA damage stimulus
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 Research Articles on Bax    1. the 14-3-3gamma/p-beta-catenin Ser37/Bax axis determines cell survival or death of neurons during ischemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Bax peptidePathways associated with Bax peptide
 Reference Product  PubMed Publications
 Bcl2 peptide  >1545 publications with Bax and Bcl2
 Bid peptide  >1174 publications with Bax and Bid
 Bak1 peptide  >614 publications with Bax and Bak1
 Tp53 peptide  >426 publications with Bax and Tp53
 Akt1 peptide  >155 publications with Bax and Akt1
 Vdac1 peptide  >35 publications with Bax and Vdac1
 Bcl2l11 peptide  >10 publications with Bax and Bcl2l11
 Xrcc6 peptide  >1 publications with Bax and Xrcc6
 Products by Pathway  Pathway Diagram
 ATM Pathway antibodies  ATM Pathway Diagram
 Activation, Translocation And Oligomerization Of BAX Pathway antibodies  Activation, Translocation And Oligomerization Of BAX Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
Organs/Tissues associated with Bax peptide
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2577 publications with Bax and Brain
 Lung Antibodies  >1407 publications with Bax and Lung
 Prostate Antibodies  >736 publications with Bax and Prostate
 Embryonic Tissue Antibodies  >295 publications with Bax and Embryonic Tissue
 Pancreas Antibodies  >267 publications with Bax and Pancreas
 Mixed Antibodies  >157 publications with Bax and Mixed
 Dorsal Root Ganglion Antibodies  >59 publications with Bax and Dorsal Root Ganglion
 Uncharacterized Tissue Antibodies  >7 publications with Bax and Uncharacterized Tissue
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